CARDIAC SURGERY

This study tested whether platelets (blood cells that help clotting) preserved by freezing work as well as or better than standard refrigerated platelets at controlling bleeding in patients undergoing heart bypass surgery. The trial involved 161 adults at risk for significant ble…

This study tested whether doctors could safely give fewer blood transfusions during heart surgery by using a special monitor that checks if the body's tissues are getting enough oxygen. Researchers compared two groups of 676 adult patients: one group received transfusions based o…

This study tested whether giving children a vitamin E injection during heart surgery could protect their heart muscle from damage. Researchers studied 58 children, aged 1-10 years, who were having surgery to correct a serious heart defect called Tetralogy of Fallot. They compared…

This study compared two different anesthesia methods during scheduled heart valve replacement surgery to see which better protects the heart muscle from stress and damage. Researchers measured troponin levels (a marker of heart stress) in 82 patients who received either sevoflura…

This study tested if using a special finger-sensor (PVI) could help doctors manage fluids more precisely during a common blood-conservation technique in heart surgery. The goal was to see if this sensor-guided approach could reduce the need for donor blood transfusions and lower …

This study tested whether using a personalized measurement of how much oxygen is in a patient's blood (called ScvO2) is better than using a standard hemoglobin number to decide when to give blood transfusions after heart surgery. The goal was to see if this personalized approach …

This study looked at whether a drug called ulinastatin, given during heart surgery, can reduce serious lung problems that sometimes happen after the operation. Researchers analyzed data from over 4,500 patients who had heart surgery and also studied how the drug might work in the…

This study tested a new way to calculate the dose of the blood-thinner heparin for obese patients during heart surgery using a heart-lung machine. Researchers compared dosing based on a patient's ideal body weight versus their total weight to see if it prevented excessive blood t…

This study tested if drinking a carbohydrate-rich beverage two hours before heart surgery helps the body manage blood sugar better compared to drinking water. Researchers enrolled 50 adult patients and measured their insulin and blood sugar levels before and after surgery. The go…

This study tested whether a sedative drug called dexmedetomidine could help protect the heart during and after major open-heart surgery. Researchers enrolled 224 patients undergoing this type of surgery to see if the drug reduced levels of a protein that signals heart muscle dama…

This study tested two simple breathing-based methods to help doctors decide if a patient needs more IV fluids right after heart surgery. The goal is to give the right amount of fluid—not too much or too little—to help patients recover better and avoid complications. Researchers c…

This study looked at whether letting natural sunlight into hospital rooms could help prevent delirium, a common state of sudden confusion, in patients recovering from heart surgery. Researchers compared 448 patients in rooms with natural light to a previous group in rooms with on…

This study compared two different nerve-block techniques for pain relief in adults having minimally invasive heart surgery through a small chest incision. Researchers wanted to see if one method was better at reducing the need for strong opioid painkillers after surgery while imp…

This study tested if numbing a patient's airway with a spray before heart surgery could help them need less strong pain medication. Using less of these medications might help keep their blood pressure and heart rate more stable during the critical start of the procedure. The goal…

This study tested whether a combined program of talk therapy and careful medication review could help reduce feelings of depression and anxiety in adults aged 60 and older who were having major heart surgery. It compared this special program to the usual care patients receive. Re…

This study tested whether using targeted nerve blocks for pain relief after major heart surgery helps patients recover faster. Researchers compared patients who received these ultrasound-guided nerve blocks to those who got standard pain medications. They looked at whether the bl…

This study tested whether a drug called dexmedetomidine, given during surgery, could help protect patients' memory and thinking skills after open heart surgery. Researchers compared the drug to a placebo in 32 patients. They measured brain function and a blood marker of brain cel…

This study tested whether a single dose of esketamine, a drug related to the anesthetic ketamine, could help reduce anxiety and depression in patients before and after heart valve surgery. Researchers enrolled 142 adults undergoing this major surgery to see if the treatment impro…

This study compared whether taking methadone as a pill before surgery works as well as getting it through an IV drip during surgery for managing pain after heart operations. It involved 41 patients having scheduled heart surgery. Researchers measured pain levels and how much addi…

This study aimed to better understand the heart muscle damage that can occur during open-heart surgery using a heart-lung machine. Researchers used detailed heart MRI scans and frequent blood tests to measure this damage in 38 patients who had aortic valve surgery. The goal was t…

This study looked at whether drops in brain oxygen levels during heart surgery are connected to memory and thinking problems that can happen after the operation. Researchers monitored 102 adult patients having planned heart surgery to see if those who had low brain oxygen were mo…

This study looked back at the medical records of 455 adults who had heart surgery using a heart-lung machine. Researchers wanted to see if certain pre-surgery blood tests, which measure inflammation and kidney function, could help predict which patients would develop sudden kidne…

This study aimed to understand how two different heart-protecting solutions affect the heart muscle during routine bypass surgery. Researchers compared a warm solution (Calafiore) and a cold solution (Modified del Nido) in 20 patients. They measured chemicals inside the heart mus…

This study aimed to see if two different ultrasound methods for measuring the pumping power of the heart's right side give the same result. Researchers compared scans taken from the chest and from inside the esophagus in 90 adults having heart surgery. The goal was to help doctor…

This study aimed to understand how doctors manage blood-thinning medications for heart patients who need surgery. Researchers observed 147 patients to see what strategies were used and track the risks of bleeding or heart problems. The goal was to gather real-world data to help d…

This study tested whether using a very low flow of anesthesia gas during heart surgery is safe and reduces environmental impact. Researchers compared two gas flow rates in 92 adults having planned heart surgery. The main goal was to see if the low-flow method used less gas and pr…

This study aimed to find out if measuring pain sensitivity around a surgical scar two days after heart surgery could predict which patients would still have chronic pain three months later. Researchers used gentle filaments to map pain areas in 84 patients who had open-heart surg…

This study aimed to understand how a specific type of cellular stress, called endoplasmic reticulum stress, changes in people during heart surgery using a heart-lung machine. Researchers measured stress markers in blood samples from 53 adults before and after their planned surger…

This study looked at over 13,000 adults who had planned heart surgery to understand why having low red blood cells (anemia) before surgery is linked to more problems after surgery. Researchers specifically investigated whether receiving a blood transfusion during the operation is…

This study aimed to understand why blood pressure readings can differ between the body's core and limbs during heart-lung bypass surgery. Researchers measured pulse waves in 40 patients undergoing scheduled heart surgery to see if this difference could be reliably detected. The g…