Heart surgery anesthesia showdown: sevoflurane vs propofol

NCT ID NCT02851433

Completed Disease control Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether the anesthetic sevoflurane protects the heart better than propofol during aortic valve replacement surgery. 82 patients were randomly assigned to receive either sevoflurane or propofol during and after surgery. The researchers measured troponin levels, a marker of heart stress, to see which anesthetic caused less damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sevoflurane (inhaled anesthetic) and Propofol (intravenous anesthetic)
What this could lead to: If sevoflurane proves better at protecting the heart during surgery, it could become the preferred anesthetic for valve replacement, reducing heart damage.
What could go wrong: This is a small, completed Phase 4 trial with only 82 participants, so results may not apply to all patients. The benefit is measured by a lab marker (troponin), not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve disorder aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY

Contacts and locations

Locations

CHU Dijon Bourgogne

Dijon, 21079, France

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