Heart surgery study probes hidden cell stress signals

NCT ID NCT03722979

Completed Knowledge-focused Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at a type of cell stress called endoplasmic reticulum (ER) stress in 53 adults having planned heart surgery with a heart-lung machine. The goal was to measure changes in ER stress markers before and after the machine was used. By studying these markers, researchers hope to better understand how the body's cells react to severe inflammation during surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help researchers understand how cells respond to severe inflammation, potentially pointing toward new targets for treatment.
What could go wrong: This is a small, early observational study with only 53 participants. It measures biological markers, not patient outcomes, so it may not lead directly to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY

Contacts and locations

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Locations

ROUEN Hospital University

Rouen, 76000, France

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