University Hospital, Rouen

This study looks at 60 adults who already have a special pacemaker and recently had a heart ablation for rapid atrial fibrillation. Researchers want to see if pacing the heart's natural electrical system (left bundle branch) helps people exercise better compared to standard right…

This study tests whether a drug that blocks endothelin-1 can improve blood vessel function and lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond to standard treatments). About 24 adults aged 30-80 will take the drug for 8 weeks. …

This study looks at two surgical options for people with a serious belly infection caused by a burst diverticulitis pocket. Half the patients will get a temporary stoma (a bag on the belly to collect waste) after the infected part of the colon is removed and reconnected; the othe…

This study compares two ways to prevent cytomegalovirus (CMV) infection in kidney transplant patients who already carry the virus. One approach gives antiviral drugs to everyone for three months, while the other uses immune system tests to decide who needs treatment. The goal is …

This study tests whether a single injection of a patient's own fat-derived stem cells into the thumb joint is safe and can relieve pain from thumb arthritis (rhizarthrosis). The treatment is for people whose standard treatments have stopped working and who are considering surgery…

This study tests if the drug apremilast can completely heal painful mouth ulcers in people with severe recurrent aphthous stomatitis who haven't responded to standard treatment. About 134 adults will receive either apremilast or a placebo for 12 weeks. The goal is to see if the d…

This study tests whether a simpler treatment for immune thrombotic thrombocytopenic purpura (iTTP) can work without the standard plasma exchange procedure. Instead, patients receive plasma infusions, immune-suppressing drugs, and a medication called caplacizumab. The goal is to s…

This study tests if giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer get the full planned treatment. About 232 adults with stable tumor genetics will be randomly assigned to standard care or the new approach. The goal is to see if …

This study tests whether taking sildenafil (Viagra) soon after rectal cancer surgery and radiation can prevent long-term erectile problems. About 188 men aged 18 to 70 with normal erectile function before treatment will take sildenafil or a placebo for 12 months. The goal is to s…

This study tests whether giving different types of chemotherapy after surgery, based on how much the tumor shrank with initial chemo, can help prevent pancreatic cancer from coming back. About 390 adults who had surgery after 3 months of a specific chemo (mFOLFIRINOX) will be ass…

This study tests whether rituximab works better than the current standard drug cyclophosphamide for people with severe mucous membrane pemphigoid, a rare autoimmune disease that causes painful blisters and scarring on mucous membranes. About 130 adults will receive either drug pl…

This study looks at whether giving hospital patients a personalized medication plan can help them stop taking strong opioids sooner, lowering the risk of dependence. About 200 adults with acute non-cancer muscle or bone pain will take part. The goal is to see if this approach wor…

This study compares two ways to treat gout: starting the drug febuxostat right after an attack versus waiting 6 weeks. Gout is a painful joint condition caused by uric acid crystals. The goal is to see if early treatment reduces the number of days with gout symptoms. About 128 ad…

This study tests whether taking oral glutamine, an amino acid, for 8 weeks can improve insulin resistance and irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo protein powder. Researchers will …

This study tests whether using a high-flow oxygen device at home can reduce the number of severe COPD flare-ups or deaths compared to standard oxygen therapy. About 406 people who have been hospitalized for a COPD attack and need long-term oxygen will take part. The goal is to se…

This study tests whether taking a low-dose aspirin daily after colon cancer surgery can lower the chance of the cancer returning. It is for patients whose tumors have a specific genetic change called PI3K mutation. The trial compares aspirin to a placebo (a pill with no medicine)…

This study compares a personalized maintenance therapy for pemphigus, where rituximab is given based on antibody levels, against the standard treatment of rituximab plus corticosteroids. About 133 adults with newly diagnosed moderate-to-severe pemphigus will take part. The goal i…

This study looks at whether a new high-resolution probe can better diagnose severe constipation that doesn't get better with standard laxatives. Researchers will compare 76 healthy volunteers and patients with suspected colonic inertia. The goal is to see if the new probe gives c…

This study is testing whether a dried blood spot test can effectively screen for hepatitis B, hepatitis C, and AIDS in people who use drugs. The goal is to make testing easier and more accessible for this group. About 500 current or former drug users will take part.

This study will test 100,000 newborns in Normandy, France, for two rare genetic diseases (MPS1 and Pompe disease) using a blood spot test. The goal is to see how common these diseases are and to improve early detection. Parents must give permission for their baby to join.

This study tests whether adding hip abductor exercises to standard pelvic floor muscle training can better reduce urine leaks in women with stress urinary incontinence. About 78 women will be split into two groups: one does pelvic floor exercises alone, the other adds hip exercis…

This study tests whether aromatherapy (using calming scents) and music therapy can help lower stress in patients having a cerebral arteriography, a brain artery scan. About 224 adults will be randomly assigned to receive one or both therapies or standard care. The goal is to see …

This study tests whether playing a special video game at home, called TOAP RUN, can help people with Parkinson's disease who have trouble walking and balancing. 80 participants will either continue their usual care or also play the game 2-3 times per week for a year. The goal is …

This study tests whether a dietary supplement called DIELEN Protect, made from glutamine and marine peptides, can reduce symptoms like belly pain and bloating in people with irritable bowel syndrome (IBS). About 100 adults with moderate to severe IBS will take the supplement or a…

This early study tests whether electrical spinal cord stimulation is safe for Parkinson's patients who have painful camptocormia, a condition where the trunk bends forward severely when standing or walking. Six participants will receive the stimulation device and be monitored for…

This study tests whether injecting a local anesthetic (ropivacaine) into the vagina before making the first cut for a hysterectomy can lower pain after surgery. About 108 adults having a hysterectomy for non-cancer reasons will be randomly assigned to receive either the anestheti…

This study looks at whether a respiratory rehabilitation program can improve sleep quality in people with stable COPD. About 90 adults aged 50 and older will be randomly assigned to either take part in the program or continue their usual care. The main goal is to see if the progr…

This study tests whether injecting botulinum toxin into the rectum can help people with fecal incontinence who haven't improved with standard treatments. About 21 adults will receive the injections and be monitored for changes in bowel muscle activity and symptom severity. The go…

This study tests whether taking glutamine, a natural amino acid, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D) who also have a 'leaky gut.' About 60 adults will receive either glutamine or a placebo daily for 8 weeks. The goal is to see …

This study looks at whether adding endurance training (like cycling) to standard physical therapy helps people recover better after minimally invasive lung cancer surgery. About 184 adults having lung surgery will be randomly assigned to standard rehab or standard rehab plus extr…

This study aims to understand the sexual and gynecological problems women may face after treatment for rectal cancer. Researchers will ask 15 women who are in remission to fill out questionnaires about their symptoms. The goal is to learn how common these issues are and what fact…

This study looks at how the antibiotic ceftriaxone works in adults treated in the emergency department for urinary tract infections. Researchers want to find out if the standard 1-gram dose is enough to kill the bacteria. About 300 patients will have their blood tested to measure…

This pilot study tests whether a drug called aprepitant (an NK1 receptor antagonist) can lower aldosterone levels in people with severe obstructive sleep apnea and high blood pressure. Researchers believe that sleep apnea may overstimulate aldosterone through nerve signals involv…

This study aims to find out how often patients on immunotherapy (cancer treatments like pembrolizumab or nivolumab) who have chronic itching also have certain antibodies (BP180 and BP230) in their blood. Researchers will enroll 100 adults with itching that started after immunothe…

This study looks at whether a substance called PlGF can act as an early warning sign for brain damage in babies exposed to alcohol before birth. Researchers will compare PlGF levels in the umbilical cord, placenta, and mother's blood between 60 mothers who drank alcohol during pr…

This study looks at the bacteria living in the airways of infants under 2 years old with severe asthma. Researchers want to understand how these bacteria differ from normal and how they relate to the immune system. The goal is to find new ways to treat severe asthma in babies. Th…

This study takes stool samples from women with eating disorders (anorexia, bulimia, or binge eating) and from healthy women, then transplants the bacteria into mice. Researchers will track the mice's weight and eating habits to see if the gut microbes play a role in these conditi…

This study looks at specific immune cells in people with thrombotic thrombocytopenic purpura (TTP), a rare blood disorder. Researchers want to understand how these cells change during the disease and after treatment. The goal is to find early warning signs of relapse, so doctors …

This study aims to collect medical information and biological samples (like blood, urine, and stool) from 2000 adults with functional digestive disorders such as irritable bowel syndrome, dyspepsia, and constipation. The goal is to identify markers that could help diagnose these …

This study looks at whether the viscosity (or 'stickiness') of the carotid artery wall differs between people with vascular dementia, Alzheimer's disease, and those without dementia. Researchers will measure artery wall behavior using ultrasound and a pressure sensor. The goal is…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can predict if liver cancer will come back after surgery. Researchers will measure ctDNA before and after surgery, and at 3 and 6 months, in 150 adults with liver cancer. The goal is to see i…

This study looks at whether a simple swallowing test done by a physiotherapist can reliably detect vocal cord paralysis after major lung surgery for cancer, compared to the standard scope exam. About 72 adults having left lung surgery or right lung surgery with lymph node removal…

This study looks at the nutritional effects of a low-calorie, high-protein diet given to people before they have weight-loss (bariatric) surgery. The goal is to see if this diet causes any health problems like low blood cell counts, vitamin deficiency, or muscle weakness. About 2…

This study looks at how a specific nerve-sliding exercise (called neurodynamic sliding mobilisation in the slump position) affects pain perception in healthy adults aged 30-65. Researchers will measure the pressure point where a sensation becomes painful, comparing the nerve-slid…

This study looks at whether using an EEG (a device that measures brain activity) can help doctors and nurses better understand sleep quality in ICU patients with acute respiratory failure. About 47 adults will have their sleep tracked by both EEG and nurse checks. The goal is to …

This study looks at whether high-flow oxygen therapy can lower pressure in the heart's blood vessels for people with chronic heart failure who have just had heart surgery. Researchers will compare it to non-invasive ventilation (a breathing machine). The goal is to understand how…

This study is following 600 people with Irritable Bowel Syndrome (IBS) over time to learn more about how the condition develops and changes. Researchers will collect information through questionnaires and stool samples. The goal is to better understand IBS, not to test a new trea…

This study looks at whether a one-minute chair lift test can help doctors predict how well patients with non-severe pulmonary embolism (a blood clot in the lungs) will recover. Researchers will compare the test results with standard risk scores and heart markers. The goal is to f…

This study aims to improve genetic counseling for spinal muscular atrophy (SMA), a severe muscle disease. Some carriers of the disease have a hidden gene duplication that current tests miss. Researchers will use advanced DNA technology to detect these hidden cases in 27 adults, h…

This study is testing a new, less invasive way to measure how much blood the heart pumps (cardiac output) in intensive care patients using ultrasound. The goal is to see if measuring blood flow from the right side of the heart works as well as the standard left-side method. The s…

This study is testing whether a new way of watching embryos grow (time-lapse imaging) helps doctors pick the best embryo for IVF, compared to the standard method. About 520 couples doing IVF for the first or second time will take part. The goal is to see which method leads to mor…

This study follows 200 adults with antiphospholipid syndrome (APS), a rare condition that increases blood clot risk. Researchers will track how often clots return and look at side effects from current treatments. The goal is to update old data and better understand real-world out…