New trial aims to boost colon cancer treatment by giving chemo before surgery
NCT ID NCT06107920
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether giving chemotherapy before surgery (neoadjuvant) helps patients with obstructive colon cancer complete their full treatment plan. About 232 adults with stable microsatellite tumors will be randomly assigned to standard care or the new sequence. The goal is to see if more patients can finish all planned chemo and surgery, potentially improving outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemotherapy (drugs given before surgery)
- What this could lead to
- If successful, this approach could help more patients with blocked colon cancer receive full treatment, potentially improving survival and reducing recurrence.
- What could go wrong
- This is a Phase 3 trial, but results are not yet known. Chemotherapy before surgery may cause side effects, and not all patients may benefit. The study is limited to specific tumor types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aphm Hopital Nord
RECRUITINGMarseille, 13015, France
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Aphm La Timone
RECRUITINGMarseille, 13005, France
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Aphp Antoine Beclere
RECRUITINGClamart, 92140, France
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Aphp Avicenne
RECRUITINGBobigny, 93000, France
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Aphp Cochin
RECRUITINGParis, 75014, France
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Aphp Georges Pompidou
RECRUITINGParis, 75015, France
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Aphp Kremlin Bicetre
RECRUITINGLe Kremlin-Bicêtre, 94275, France
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Aphp Saint Antoine
RECRUITINGParis, 75012, France
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CHU CAEN
RECRUITINGCaen, 14000, France
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CHU LYON
RECRUITINGPierre-Bénite, 69495, France
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Ch Poissy
RECRUITINGPoissy, 78303, France
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Ch St Denis
RECRUITINGSaint-Denis, 93200, France
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Ch Versailles
RECRUITINGVersailles, 78150, France
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Chr Beauvais
RECRUITINGBeauvais, 60021, France
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Chru Besancon
RECRUITINGBesançon, 25030, France
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Chru Lille
RECRUITINGLille, 59037, France
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Chru Lille
RECRUITINGLille, 59037, France
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Chru Nancy
RECRUITINGNancy, 54511, France
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Chu Amiens
RECRUITINGAmiens, 80054, France
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Chu Colmar
RECRUITINGColmar, 68024, France
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Chu Dijon
RECRUITINGDijon, 21079, France
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Chu Grenoble
RECRUITINGGrenoble, 38043, France
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Chu Limoges
RECRUITINGLimoges, 87042, France
-
Chu Nantes
RECRUITINGNantes, 44093, France
-
Chu Rouen
RECRUITINGRouen, 76031, France
-
Chu Strasbourg
RECRUITINGStrasbourg, 67200, France
-
Chu Tours
RECRUITINGTours, 37170, France
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Gh Diaconesses Croix St Simon
RECRUITINGParis, 75960, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can artificial intelligence think like a cancer tumor board?
- A new clue in the fight against colorectal cancer recurrence?
- Can radiation plus immunotherapy make colon tumors disappear before surgery?
- Can a chemo boost outsmart lingering colon cancer cells?
- Does practice make perfect? a study probes how a Surgeon's learning curve impacts cancer surgery success