Can radiation plus immunotherapy make colon tumors disappear before surgery?
NCT ID NCT06949111
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial is testing whether adding radiotherapy and immunotherapy to standard chemotherapy can shrink advanced colon tumors more effectively than chemotherapy alone. Adults with a specific type of stage T4M0 colon cancer will receive either the combination or chemotherapy only, followed by surgery if possible. The goal is to see if the combination improves complete tumor disappearance and increases the chance of successful surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiotherapy combined with chemotherapy (CAPOX) and immunotherapy (iparomlimab and tuvonralimab)
- What this could lead to
- If successful, this combination could shrink advanced colon tumors enough to allow complete surgical removal, potentially improving long-term outcomes and preserving nearby organs.
- What could go wrong
- This is an early-phase trial with a modest number of participants, so results may not hold in larger groups. Combining radiation, chemotherapy, and immunotherapy can also increase the risk of side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
the Fourth Hospital of Hebei Medical University
RECRUITINGShijiazhuang, Hebei, 050000, China
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