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Can a chemo boost outsmart lingering colon cancer cells?

NCT ID NCT05534087

Recruiting now Disease control Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This trial is testing whether giving a stronger chemotherapy regimen (mFOLFIRINOX) early can improve outcomes for people with stage II-III colon cancer who still have signs of cancer DNA in their blood during standard adjuvant chemo. Participants are randomly assigned to either receive the intensified treatment or continue with standard chemo. The goal is to see if the intensified approach can reduce the chance of cancer returning or spreading.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Intensified chemotherapy with modified FOLFIRINOX regimen
What this could lead to
If successful, this approach could offer a more effective treatment strategy for colon cancer patients at high risk of recurrence, potentially improving their chances of staying cancer-free.
What could go wrong
The intensified regimen may cause more side effects, and it's uncertain whether it will improve survival compared to standard treatment. The trial is still ongoing, and results are not yet available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER

Contacts and locations

Locations

  • Ajou University Hospital

    RECRUITING

    Suwon, South Korea

  • Asan Medical Center

    RECRUITING

    Seoul, South Korea

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Hwasun, South Korea

  • Chung-Ang University Hospital

    RECRUITING

    Seoul, South Korea

    Contact Email: •••••@•••••

  • Dong-A University Hospital

    RECRUITING

    Busan, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, South Korea

  • Kyungpook National University Chilgok Hospital

    RECRUITING

    Daegu, South Korea

  • National Cancer Center

    RECRUITING

    Goyang, South Korea

  • SMG-SNU Boramae Medical Center

    RECRUITING

    Seoul, South Korea

  • Samsung Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, South Korea

  • Severance Hospital

    RECRUITING

    Seoul, South Korea

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