Seoul National University Hospital

This large trial tests two types of intravenous fluids given during heart surgery: hydroxyethyl starch (HES) and balanced crystalloids. The goal is to see which fluid leads to fewer serious kidney problems, such as kidney failure or death. About 1,292 adults having heart surgery …

This study tests whether taking branched-chain amino acid (BCAA) supplements for three months after knee replacement surgery can help improve muscle mass and strength in patients with sarcopenia (age-related muscle loss). About 140 adults aged 40 to 100 will be randomly assigned …

This study follows 21 adults who previously received an injection of stem cells from donated umbilical cords to treat rotator cuff disease. Researchers want to see if the treatment remains safe and helps with shoulder pain and function over the long term. Participants fill out qu…

This study tests a new pacing method called left bundle branch area pacing for people with heart failure whose heart pumps less blood than normal (ejection fraction 50% or lower). It is for patients who cannot get standard pacing or need a backup option. The goal is to see if thi…

This study tests a new, faster method for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 150 adults will receive a heart ablation using very high power for short durations, aiming to reduce procedure time. The goal is to see if this approach is as …

This study tests whether a 12-week home-based cardiac rehabilitation program can improve heart function and quality of life in children aged 8 to 18 with complex congenital heart disease. Participants will be randomly assigned to either the remote rehab program or standard care. …

This study compares two approaches to taking blood thinners after a common heart procedure for atrial fibrillation. One group takes blood thinners every day as usual, while the other takes them only when a small implanted monitor detects an irregular heartbeat. The goal is to see…

This study tests whether treating extra scar tissue in the heart's upper chamber, along with the standard vein isolation, can better control atrial fibrillation (AF) in people with persistent AF. About 204 adults with moderate scarring will be randomly assigned to standard treatm…

This study tests whether stem cells from donated umbilical cords can safely help heal partial rotator cuff tears. 21 adults with shoulder pain for at least 3 months who haven't improved with other treatments will receive a single injection of stem cells into the tear. Researchers…

This study looks at whether people with well-controlled gout (for at least 5 years) can safely reduce or stop their daily febuxostat. Fifty-nine adults will be split into three groups: one that lowers the dose, one that stops for 6 months then restarts a lower dose, and one that …

This study compares two approaches for people with ischemic cardiomyopathy (weak heart muscle due to blocked arteries) and multiple blocked vessels. One group gets optimal medical therapy alone, while the other also gets a heart artery procedure (PCI) guided by imaging and pressu…

This study tests a new method to check if a liver cancer treatment called radioembolization is safe for the lungs. Currently, doctors use a test particle (MAA) to estimate lung radiation risk, but it may not be perfectly accurate. The new method uses a small 'scout dose' of the a…

This study is testing a new microwave ablation device to treat small liver cancers (up to 4 cm). Doctors will use ultrasound guidance to insert a thin antenna into the tumor and apply microwave energy to heat and destroy it. The goal is to see how often the tumor is completely el…

This study tests whether people with large liver cancer (over 5 cm) can get their entire radioembolization treatment in a single day. Normally, planning scans and treatment are done on separate days. The procedure involves injecting tiny radioactive beads into the liver's blood s…

This study tests a faster version of radioembolization for people with small liver cancers (5 cm or less). Normally, doctors do a pre-treatment scan to check for lung risks, but this trial skips that step for carefully selected patients. The goal is to see if the simplified appro…

This phase 2 trial tests whether combining two drugs, venetoclax and decitabine, can help adults with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to treatment. The study will enroll 28 participants and measure how many achieve complete remi…

This study is observing how well a double umbilical cord blood transplant works for 40 adults with blood cancers like leukemia or lymphoma. The transplant uses two units of cord blood from unrelated donors to help rebuild the patient's blood system. Researchers are tracking survi…

This phase 2 trial tests the drug bortezomib in 29 adults with relapsed or refractory immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, raising bleeding risk. Participants receive bortezomib injections over three weeks for three cycles, then a…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. About 464 participants will be randomly assigned to either have or skip the surgery. The goal is to see if skipping surgery…

This study is testing whether taking clopidogrel (a blood thinner) every day for at least 5 years can prevent heart attacks, strokes, and death in people who have early signs of coronary artery disease on scans but no symptoms. About 11,000 adults aged 40 and older will be assign…

This study tests a personalized approach to managing fluids during brain surgery for children with Moyamoya disease. Instead of standard blood pressure targets, doctors will use each child's baseline heart function to guide fluid delivery. The goal is to reduce temporary stroke-l…

This study tests whether the drug maribavir can safely control cytomegalovirus (CMV) infections in people with multiple myeloma or lymphoma who are receiving bispecific antibody therapy. About 20 adults will take maribavir, and researchers will measure how well it lowers CMV leve…

This study is testing whether the antiviral drug letermovir can prevent a common and serious viral infection called CMV in people with relapsed/refractory multiple myeloma who are receiving the immunotherapy elranatamab. The trial will enroll 40 adults who are CMV-positive. Resea…

This study tests whether adding a trastuzumab biosimilar (SB3) to the chemotherapy drug eribulin helps control advanced HER2-positive breast cancer better than eribulin alone. It includes 180 adults whose cancer has spread or cannot be removed and who have already tried at least …

This study is testing a new ultrasound technology called DeepUSFF to measure fat in the liver of people with metabolic fatty liver disease (MASLD). Researchers will compare the ultrasound results to MRI scans, which are the current gold standard. If the ultrasound works well, it …

This study tests whether using audio and visual tools—like familiar sounds, pictures, and better sleep conditions—can prevent delirium (sudden confusion) in intensive care patients. About 196 adults over 50 who are expected to stay in the ICU for more than a day will take part. T…

This study looks at whether playing binaural beats (a type of sound) through earphones during cataract surgery can help older patients feel more satisfied and comfortable. About 60 people aged 65 and older will take part, with half listening to the sounds and half wearing earphon…

This study tests whether a 6-week swallowing rehabilitation program can improve swallowing function in people with multiple system atrophy (MSA) who have trouble swallowing. 24 adults with MSA and confirmed swallowing problems will receive either the full rehab program or a singl…

This study looks at whether using a lower suction setting on a chest drainage device after lung cancer surgery can help the chest tube come out sooner. About 160 adults having part of a lung removed will be randomly assigned to either the standard suction or a gentler one. The go…

This study tests whether a special compression vest, which provides gentle pressure like a hug, can reduce confusion and agitation in children ages 3 to 10 after tonsil and adenoid surgery. Half the children will wear the vest in the recovery room, and the other half will receive…

This study tests whether a special nerve block (EOI block) can reduce pain and the need for strong painkillers in teenagers having ear reconstruction surgery using rib cartilage. Sixty participants aged 13 to 18 will be randomly assigned to receive either the nerve block or stand…

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This study tests whether a special recovery plan (ERAS) helps people recover faster after minimally invasive stomach cancer surgery. The plan includes education before surgery, shorter fasting, early eating and walking, and less use of strong painkillers. Researchers will track h…

This study is checking how well the Dexcom G7, a continuous glucose monitor, works in 100 adults having heart surgery. The device is placed on the arm and tracks blood sugar during and after the operation for up to 10 days. The goal is to see if it gives accurate readings in this…

This study looks at how well the shingles vaccine (Shingrix) works in people with lupus compared to healthy people of the same age and sex. Researchers will measure immune cell responses after two doses and follow participants for up to 5 years. The goal is to understand if the v…

This study tests whether giving a drug to reverse muscle relaxants after placing a breathing tube helps doctors check brain function sooner. Thirty critically ill adults in the ICU will receive either sugammadex, neostigmine, or no reversal drug. Researchers will measure how quic…

This study looks at whether a new cutoff for a blood test (aldosterone-renin ratio) can better identify people with primary aldosteronism, a common cause of high blood pressure. About 150 adults with hypertension and certain lab results will be tested using the new cutoff and the…

This study tests whether a mixed reality (MR) system called HEROS 4.0 can teach CPR as effectively as traditional instructor-led classes. 120 adults who haven't had CPR training in the last year will be split into two groups: one using MR and one using standard video and in-perso…

This study is following 1,000 people in Korea who have symptoms of sleep apnea, like loud snoring or feeling very tired during the day. The goal is to learn more about the condition and how well patients stick with breathing machine therapy. Participants will have sleep tests and…

This study observes 80 adults undergoing airway surgery with a special oxygen technique called THRIVE. Researchers will record when oxygen levels drop low enough to require rescue ventilation. The goal is to find factors that predict this event, helping anesthesiologists plan saf…

This study observes 100 people in Korea with advanced HER2-positive breast cancer who take a drug called T-DM1 right after another drug, T-DXd, stops working. Researchers will track how long the cancer stays controlled and how well patients respond. The goal is to learn if this d…

This study tests two methods of giving the anesthetic remimazolam during cerebrovascular bypass surgery in people with moyamoya disease. One method uses a computer-controlled pump (TCI), the other uses manual weight-based dosing. The goal is to see which approach uses less total …

This study compares two ways of placing a midline catheter (a type of IV) in children aged 2 to 17. Doctors will randomly assign 96 kids to have the catheter placed in either the basilic or cephalic vein. The goal is to see which approach allows easier blood draws and causes fewe…

This study looks at whether inserting a breathing tube through the left or right nostril causes fewer nosebleeds in adults having planned surgery. Researchers will compare nosebleed rates between the two nostrils in 208 participants. The goal is to find a simple way to reduce a c…

This study talks to people who had a near-death experience while in the hospital's intensive care unit (ICU). Researchers want to learn how common these experiences are and what they are like. About 200 adults who survived serious events like cardiac arrest or coma will be interv…

This study is observing 165 adults with coronary artery disease who are getting a drug-coated balloon procedure. Researchers will use CT scans before and after the procedure to measure changes in blood flow and plaque buildup. The goal is to learn how the balloon affects the arte…

This study watches 40 adults with atrial fibrillation who get a new type of heart treatment called pulsed field ablation. The goal is to see if the procedure causes tiny, symptom-free brain spots that show up on MRI scans. Researchers want to know how often these spots happen and…

This study is tracking over 5,000 adults who had a cardiac arrest outside the hospital to learn what causes it and who is at risk. Researchers will look at health habits, chronic diseases, and develop a prediction model. The goal is to find new ways to prevent these life-threaten…

This study tests two anesthetic drugs, sufentanil and remifentanil, in 92 people having brain bypass surgery. The goal is to see which drug better prevents dangerously low blood pressure during the operation. Researchers will also monitor heart rate and the need for additional bl…