Seoul National University Hospital

This trial compares a personalized dosing method for the sedative remimazolam to standard weight-based dosing in adults having non-cardiac surgery. The goal is to see if the personalized approach helps patients wake up faster and reduces drug buildup. Participants are randomly as…

This phase 3 trial tests whether a 6-month combination of five drugs (bedaquiline, delamanid, delpazolid, levofloxacin, and pyrazinamide) works as well as standard treatment for rifampicin-resistant tuberculosis in adults and adolescents aged 15 and older in South Africa. The stu…

This study will compare two approaches for people with chronic coronary syndrome (narrowed heart arteries): getting a stent plus standard medications versus medications alone. About 2,301 participants will be randomly assigned to one group, and researchers will track major heart …

This study tests whether an AI-based system that gives personalized diet advice can help people eat better and improve their metabolic health. Two hundred adults who had a health checkup will be split into three groups: one gets a fixed diet plan from AI, another gets a plan that…

This study tests whether naltrexone, a drug already used for addiction, can help people who hurt themselves without intending suicide. About 150 people will receive either naltrexone or a placebo daily for 6 weeks, alongside their usual care. Researchers will track how many self-…

This study tests whether naltrexone, a medication, can help reduce nonsuicidal self-injury (like cutting or hitting oneself) in people aged 16 and older. About 150 participants will receive either naltrexone or a placebo, and researchers will track how often self-harm occurs. The…

This study looks at whether adding a short course of chemotherapy after standard chemoradiation can improve outcomes for people with stage I rectal cancer, allowing them to keep their rectum instead of needing major surgery. About 292 participants will be randomly assigned to rec…

This study tests a special pacing method for people with heart failure and a type of heart block. The goal is to see if pacing a specific area of the heart can improve heart function and quality of life. About 120 adults with heart failure and reduced pumping ability will partici…

This study tests a combination of three drugs (nemtabrutinib, bortezomib, and rituximab) in people with Waldenstrom's macroglobulinemia, a rare blood cancer. The goal is to see how well the treatment shrinks tumors and controls the disease. About 19 adults who have not yet been t…

This study tests a method called PIPAC, where the chemotherapy drug paclitaxel is turned into a pressurized spray and delivered directly into the abdomen. It is for women with ovarian cancer that has come back and no longer responds to platinum-based chemotherapy. The trial has t…

This early-phase trial tests whether combining three drugs (golcadomide, poseltinib, and rituximab) can shrink or control tumors in people with relapsed or refractory large B-cell lymphoma. About 20 adults will take part. The goal is to see if the combination works better than cu…

This clinical trial is for adults with metastatic clear cell kidney cancer. It compares having surgery to remove the kidney tumor either before or after starting immunotherapy drugs (ipilimumab and nivolumab). The goal is to see which timing helps people live longer without the c…

This study compares two surgical methods for early-stage cervical cancer (IB2-IIA1). One is traditional open surgery, and the other is a minimally invasive approach using a stapler to prevent cancer cells from spreading. About 494 participants will be followed for 4.5 years to se…

This study compares two strategies for slowly reducing prednisolone (a steroid) in people with stable rheumatoid arthritis. One method splits a 5 mg tablet into halves, the other reduces by 1 mg at a time. Over six months, 206 participants will be followed to see which approach k…

This study will test whether letting patients control their own sedation during hip replacement surgery is better than having a doctor control it. About 104 adults will be randomly assigned to either press a button for extra sedation or have a clinician adjust the medication. The…

This study compares two ultrasound-guided nerve blocks—the External Oblique Intercostal (EOI) block and the Subcostal Transversus Abdominis Plane (TAP) block—for pain relief after minimally invasive liver surgery. 140 adults will be randomly assigned to receive one of the blocks …

This study tests whether giving a single dose of the steroid dexamethasone during nasal surgery can improve sleep quality on the first night after the operation. About 102 adults having nasal surgery under general anesthesia will be randomly assigned to receive either dexamethaso…

This study will test whether people with Parkinson's disease can safely follow a home-based exercise program using video instructions and real-time feedback from a camera. Fifteen participants will do exercises like stretching, strength training, and balance work at home for 6 we…

This study is testing different amounts of IV fluid given during spinal anesthesia for planned C-sections to find the smallest dose that prevents dangerously low blood pressure in 90% of women. 45 healthy pregnant women at term will receive a specific fluid volume right after the…

This study tests if playing special sounds called binaural beats through earphones during breast reconstruction surgery can lower the dose of anesthesia drug remimazolam needed. 88 adults will be randomly assigned to hear either binaural beats or silence. The goal is to see if th…

This study tests whether a 12-week mobile app therapy called Multimodal Acoustic Therapy (MAT) can improve how well children and teens with cochlear implants perceive music and enjoy it. Twenty-five participants aged 10 to 19 will use the app at home and be followed for another 1…

This study tests whether a newer anesthesia drug (remimazolam) followed by a reversal agent (flumazenil) leads to a calmer, smoother awakening compared to standard propofol anesthesia in adults having nasal surgery. About 204 participants will be randomly assigned to one of the t…

This study tests whether two different ultrasound machines can accurately measure liver stiffness and inflammation in people with fatty liver disease. About 95 to 100 adults will take part, including healthy liver donors and patients with fatty liver. The goal is to see if these …

This study tests whether an artificial intelligence (AI) analysis of a simple electrocardiogram (ECG) can safely replace routine heart ultrasound (echocardiography) in managing atrial fibrillation (AF). About 1,724 adults with AF will be randomly assigned to either AI-ECG guided …

This study will create a tool to predict complications after major surgery in people aged 65 and older. Researchers will collect information on physical activity, nutrition, mood, and body composition from 520 participants before surgery. The goal is to help doctors better identi…

This study will compare two types of videolaryngoscope blades (hyperangulated vs. Macintosh) in 524 adults undergoing general anesthesia to see which leads to higher first-attempt intubation success. The goal is to develop a predictive algorithm that personalizes blade selection …

This study looks at how the body's immune response and nutrition are linked to the progression of nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will analyze immune cells from the lungs and blood of 50 adults with confirmed or suspe…

This study will examine immune cells found in fluid from the lungs of 60 people with advanced lung cancer. Researchers want to see if these cells can help predict how well standard cancer treatments work. Participants will have a bronchoscopy as part of their regular care, and th…