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Can a daily pill stop heart attacks in people with hidden artery disease?

NCT ID NCT05845489

Disease control Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether taking clopidogrel (a blood thinner) every day for at least 5 years can prevent heart attacks, strokes, and death in people who have early signs of coronary artery disease on scans but no symptoms. About 11,000 adults aged 40 and older will be assigned to either take clopidogrel or receive no blood-thinning medication. The goal is to see if early treatment can stop the disease from getting worse.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
clopidogrel
What this could lead to
If it works, this could provide a way to prevent major heart events in people with early, symptom-free coronary artery disease.
What could go wrong
This is a large Phase 4 trial, but clopidogrel is already known to increase bleeding risk. The benefit in this specific population is unproven, and the study requires long-term daily medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 11,086 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Dec 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female aged ≥40 years * Patients with subclinical coronary atherosclerosis identified from coronary CT angiography or coronary angiography within 2 years without clinical events after an imaging study * Without significant coronary artery stenosis (Diameter stenosis \>50%), which needs revascularization * Agreement to give written informed consent Exclusion Criteria: * A history of a diagnosed cardiovascular or cerebrovascular disease (Type1 myocardial infarction, heart failure, peripheral artery disease, stroke, transient ischemic attack, carotid artery stenosis\>50%, carotid artery intervention) * A history of coronary artery intervention or coronary artery bypass graft surgery, which needs chronic maintenance of antiplatelet therapy * Absolute contraindication or allergy to clopidogrel * Patients receiving anticoagulants for other comorbidities * A history of Bleeding diathesis, known coagulopathy, or major bleeding, BARC class ≥3, resulting in the stop of antiplatelet agents * Planned surgery or intervention which needs to stop antiplatelet agents ≥1 month * Presence of non-cardiac comorbidity with life expectancy ≤ 5 years at randomization * Females with pregnancy or breast-feeding * Patients who are thought to be inappropriate for the trial based on physicians' decision

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Conditions

The condition(s) this trial relates to.

coronary artery disorder coronary atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    61 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Andong Hospital

    RECRUITING

    Andong, South Korea

  • Catholic Kwandong University International St. Mary's Hospital

    RECRUITING

    Incheon, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Hwasun, South Korea

  • Chung-Ang University Gwangmyeong Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • Chung-Ang University Hospital

    RECRUITING

    Seoul, South Korea

  • Chung-Ang University Hospital

    RECRUITING

    Seoul, South Korea

  • Chungbuk National University Hospital

    RECRUITING

    Cheongju-si, South Korea

  • Chungnam National University Hospital

    RECRUITING

    Daejeon, South Korea

  • Chungnam National University Sejong Hospital

    RECRUITING

    Sejong, South Korea

  • Dong-A University Hospital

    RECRUITING

    Busan, South Korea

  • Eulji University Hospital, Daejeon

    RECRUITING

    Daejeon, South Korea

  • Eulji University Hospital, Uijeongbu

    RECRUITING

    Gyeonggi-do, South Korea

  • Ewha Womans University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Ewha Womans University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Gachon University Gil Medical Center

    RECRUITING

    Incheon, South Korea

  • Gangneung Asan Hospital

    RECRUITING

    Gangneung, South Korea

  • Gyeongsang National University Changwon Hospital

    RECRUITING

    Changwon, South Korea

  • Gyeongsang National University Hospital

    RECRUITING

    Jinju, South Korea

  • Hallym University Chuncheon Sacred Heart Hospital

    RECRUITING

    Chuncheon, South Korea

  • Hallym University Dongtan Sacred Heart Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • Hallym University Kangdong Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Hallym University Kangdong Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Hallym University Kangnam Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Hallym University Sacred Heart Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • Hanyang University Hospital

    RECRUITING

    Seoul, South Korea

  • Inje University Busan Paik Hospital

    RECRUITING

    Busan, South Korea

  • Inje University Ilsan Paik Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • Inje University Sanggye Paik Hospital

    RECRUITING

    Seoul, South Korea

  • Jeju National University Hospital

    RECRUITING

    Jeju City, South Korea

  • Jesus Hospital, Jeonju

    RECRUITING

    Jeonju, South Korea

  • Kangbuk Samsung Hospital

    RECRUITING

    Seoul, South Korea

  • Kangwon National University Hospital

    RECRUITING

    Chuncheon, South Korea

  • Kangwon National University Hospital

    RECRUITING

    Chuncheon, South Korea

  • Keimyung University Dongsan Hospital

    RECRUITING

    Daegu, South Korea

  • Korea University Anam Hospital

    RECRUITING

    Seoul, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, South Korea

  • Kosin University Gospel Hospital

    RECRUITING

    Busan, South Korea

  • Kwangju Christian Hospital

    RECRUITING

    Gwangju, South Korea

  • Kyung Hee University Hospital

    RECRUITING

    Seoul, South Korea

  • Myongji Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • National Health Insurance Service Ilsan Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • Pohang Stroke And Spine Hospital

    RECRUITING

    Pohang, South Korea

  • Pusan National University Hospital

    RECRUITING

    Busan, South Korea

  • Samsung Medical Center

    RECRUITING

    Seoul, South Korea

  • Sejong General Hospital, Bucheon

    RECRUITING

    Gyeonggi-do, South Korea

  • Seoul Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul Metropolitan Government - Seoul National University Boramae Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, Other, 03080, South Korea

  • Soonchunhyang University Bucheon Hospital

    RECRUITING

    Gyeonggi-do, South Korea

  • Soonchunhyang University Cheonan Hospital

    RECRUITING

    Cheonan, South Korea

  • Soonchunhyang University Cheonan Hospital

    RECRUITING

    Cheonan, South Korea

  • Soonchunhyang University Cheonan Hospital

    RECRUITING

    Cheonan, South Korea

  • Soonchunhyang University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Ulsan University Hospital

    RECRUITING

    Ulsan, South Korea

  • Veterans Health Service Medical Center

    RECRUITING

    Seoul, South Korea

  • Yeungnam University Medical Center

    RECRUITING

    Daegu, South Korea

  • Yonsei University Gangnam Severance Hospital

    RECRUITING

    Seoul, South Korea

  • Yonsei University Wonju Severance Christian Hospital

    RECRUITING

    Wŏnju, South Korea

  • Yonsei University Yongin Severance Hospital

    RECRUITING

    Gyeonggi-do, South Korea

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