University Hospital, Rouen

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured how wel…

This study looked at giving chemotherapy before surgery for people with pancreatic cancer that can be removed. The goal was to see if this approach helps patients live longer and have fewer complications compared to the standard treatment of surgery followed by chemo. The trial i…

This study tested whether a single cycle of the drug rituximab can control bullous pemphigoid, a painful blistering skin condition. Researchers followed 18 adults for up to two years to see if the drug stopped the disease and checked for side effects. The goal was to find a treat…

This study tested a weekly combination of two chemotherapy drugs (cisplatin and irinotecan) along with radiation in 43 people with advanced esophageal cancer that hadn't spread to other organs. The main goal was to see how many patients had no cancer detectable after treatment. R…

This study tested two chemotherapy combinations in 500 bladder cancer patients to see which works better before or after bladder removal surgery. One group received gemcitabine plus cisplatin, the other a high-dose version of MVAC. The goal was to see which regimen delays cancer …

This study tested whether a one-on-one talk with a pharmacist, who created a personalized plan, could help people with non-cancer pain stop taking strong opioids sooner. About 100 adults in a hospital rheumatology department took part. The goal was to see if the plan kept opioid …

This study looked at 102 adults with a severe infection in the belly from a burst colon pocket (diverticulitis). It compared two surgeries: one that reconnects the colon right away and one that leaves a temporary opening. The main goal was to see which approach leads to fewer dea…

This study tested a nerve surgery in 4 adults with bilateral vocal fold paralysis (both vocal cords stuck closed) who had not improved with prior endoscopic treatment. The surgery rerouted nerves to restore movement to the vocal cords. After 6-9 months, improvements in voice and …

This study looked at whether a specific chemotherapy and radiation plan is feasible for people with gastric cancer. 63 patients received treatment either before or after surgery to remove their stomach tumor. The goal was to see if the treatment plan could be completed without ma…

This study tested whether adding a special collagen-elastin matrix under a skin graft helps the skin become more flexible and less scarred. About 92 adults with skin loss from injury or surgery received either a skin graft with the matrix or a graft alone. The main goal was to me…

This study looked at whether using a noninvasive ventilation mask (NIV) can help patients with chronic respiratory failure get off a breathing tube more successfully. Researchers compared three weaning methods in 205 patients who had trouble breathing on their own. The goal was t…

This study tested whether a program of exercise combined with a daily drink containing leucine and arginine (amino acids) could help obese adults with metabolic syndrome lose body fat. 79 participants followed the program for several weeks. The main goal was to see if total body …

This study tested two treatment combinations for acquired hemophilia, a rare condition where the body attacks its own blood-clotting factor. 110 adults received either steroids plus cyclophosphamide or steroids plus rituximab. The goal was to see which combo better eliminates the…

This study compared two treatments for deep endometriosis in the rectum: long-term hormones or surgery. 78 women aged 35-50 who did not plan pregnancy were randomly assigned to either 24 months of hormone therapy or rectal surgery followed by hormones. The goal was to see which a…

This study tested whether taking dapagliflozin for 12 weeks improves blood vessel function in people with chronic kidney disease. 32 adults with moderate kidney disease took the drug, and researchers measured changes in artery health using ultrasound. The goal was to see if this …

This study looked at whether a blood test called the Basophil Activation Test (BAT) can accurately diagnose peanut and egg allergies in children. Currently, the best way to diagnose these allergies is a food challenge, where children eat increasing amounts of the allergen under m…

This study tested a special microscope (confocal endomicroscopy) that can be inserted through a bronchoscope to look at lung nodules in real time. The goal was to see if it can find nodules and tell whether they are cancerous or benign without needing to remove tissue. 120 adults…

This study tested a new device called EndoFLIP to see if it can better diagnose anismus, a condition where the anal muscles don't relax properly during bowel movements, causing severe constipation. Researchers measured anal stretchiness in 61 adults with long-term constipation an…

This study looked at a new blood marker called EM66 to see if it can better tell apart people with rare adrenal tumors (pheochromocytoma or paraganglioma) from those with regular high blood pressure. About 60 adults with suspected tumors or known genetic risk took part. The goal …

This study aimed to develop and validate a new molecular test for COVID-19 using saliva samples instead of the standard nose swab. Researchers tested 130 adults at a French hospital to see if the saliva method could accurately identify positive and negative cases. The goal was to…

This study tested a new, objective method to check if a patient's skin is clean before surgery. Researchers compared a simple swab test (ATPmetry) against the current standard, which is a nurse looking at the skin. The goal was to see if the swab test is a reliable and practical …

This study looked at whether giving patients their pain medication prescription before surgery (during the anesthesia check-up) leads to less pain at home after day surgery compared to giving the prescription after surgery. About 200 adults having day surgery with general anesthe…

This study tested whether injecting botulinum toxin (like Botox) into the rectum can reduce episodes of fecal incontinence and urgency in 200 adults who did not get better with standard treatments. Participants kept a bowel diary to track changes. The goal was to improve quality …

This study tested whether avoiding morphine during heart surgery could lower the risk of serious complications like breathing trouble, confusion, and gut paralysis. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia…

This study tested whether a non-invasive brain stimulation technique called rTMS can help people with psychogenic paralysis (paralysis with no physical cause). 66 participants received either real or sham rTMS over two days. The main goal was to see if paralysis improved right af…

This study tested two types of breathing support for people with severe fluid buildup in the lungs (pulmonary edema). One method delivers steady air pressure (CPAP), while the other gives two levels of pressure (bilevel). The goal was to see which one improves breathing faster. A…

This study looked at 60 women with deep endometriosis affecting the rectum. It compared two surgical approaches: removing the affected part of the rectum versus just cutting out the endometriosis nodules. The goal was to see which method leads to fewer bowel and bladder problems …

This study tested whether spraying a drug called terlipressin into the airways before taking lung tissue samples (biopsies) can reduce bleeding. The goal was to allow doctors to take more samples safely, which could improve the chance of diagnosing lung cancer. The trial involved…

This study tested a new way to use deep brain stimulation (DBS) to help with walking and balance problems in people with Parkinson's disease. The researchers used a special electrode that can shape the electrical field more precisely. Nineteen patients who were already getting DB…

This study tested whether a gynecological exam done while lying on the side (lateral decubitus) works well enough to be a regular alternative to the standard position. Over 500 women who needed a pelvic exam took part. The goal was to see if this position could make the exam more…

This study tested whether applying the numbing medicine ropivacaine to a skin graft donor site reduces pain after surgery. 58 adults who needed a small skin graft were randomly assigned to receive either ropivacaine or a saltwater solution on their wound. The main goal was to see…

This study tested two different methods for removing surgical drains after total hip replacement to see which one hurts less. 87 adults who had hip surgery took part. Researchers measured pain right after removal and checked for bruising.

This study looked at whether a diet low in FODMAPs (certain carbohydrates) can ease symptoms of Irritable Bowel Syndrome (IBS). Researchers tested 112 adults with IBS to see if a fructose breath test could predict who would benefit from the diet. The goal was to find a simple way…

This study looked at whether a breath test can detect bacterial overgrowth in the small intestine that might cause gas incontinence. Sixteen adults with gas incontinence for over 3 months were tested. Those with positive results received antibiotics to see if their symptoms impro…

This study tested whether using two types of nerve blocks together (paravertebral and serratus plane blocks) works better than just one for pain control after video-assisted lung surgery. 112 adults aged 18 to 75 took part. The main goal was to see if the double block reduces the…

This study tested whether breathing in morphine works as well as getting it through an IV for treating severe pain in the emergency department. 226 adults with intense pain were randomly assigned to receive either inhaled morphine plus a placebo IV, or IV morphine plus a placebo …

This study looked at whether using a fast-acting opioid called remifentanil during general anesthesia for emergency C-sections is safe for premature babies. It involved 53 mothers and their newborns. The main goal was to see if the babies had healthy Apgar scores (a measure of ne…

This study looked at whether regular moderate physical activity can reduce chronic fatigue and improve quality of life in people with inactive inflammatory bowel disease (IBD). Only 3 participants completed the program. The researchers measured fatigue and quality of life before …

This study tested whether a program of balance and posture exercises on a foam surface could reduce urine leakage in women with stress urinary incontinence (leaking when coughing, sneezing, or exercising). 88 women participated. The goal was to see if this non-invasive, drug-free…

This pilot study tested a very small, specially shaped wire (lead) for cardiac resynchronization therapy in 39 adults. The goal was to see if the wire could successfully pace the left ventricle of the heart. The study measured how often the wire provided effective pacing and chec…

This study looked at how often sleep disturbances occur in people with bullous pemphigoid, a rare blistering skin condition. Researchers compared 122 patients to a control group using a simple sleep questionnaire. The goal was to understand if sleep issues are more common in thes…

This study looked at how different types of brain damage (from stroke, tumors, or diseases) affect thinking skills like memory and attention. Researchers used brain scans and cognitive tests in 346 patients and healthy volunteers to link specific brain areas to specific mental ab…

This study looked at 52 ICU patients with septic shock to understand why they lose muscle mass. Researchers measured a protein called PTP1B and checked muscle size using ultrasound. They also tested blood levels of zonulin, a marker of gut health. The goal was to find links betwe…

This study looked at how the immune system's T-cells respond to the COVID-19 virus in hospitalized patients. Researchers measured the number of T-cells that produce a key immune signal (interferon-gamma) when exposed to the virus's spike protein. The goal was to better understand…

This study looked at why some people with pemphigus, a rare skin disease, feel more vulnerable than others. Researchers interviewed 48 patients to understand how misdiagnosis, disagreements with doctors, and use of health information affect their experience. The goal was to ident…

This study tested a new, more detailed method (high-resolution manometry) to measure anal muscle function in 60 people—some with fecal incontinence and some healthy. The goal was to see if this method gives better information than older techniques. The study is complete and focus…

This study looked at 216 people with stage II or III colorectal cancer who had surgery to remove their tumor. Researchers compared two blood tests—one that looks for tumor DNA and another that looks for tumor cells—to see which better predicts if the cancer will come back within …

This study tested whether ultrasound can detect early signs of rheumatoid arthritis (RA) flare-ups in 30 patients treated with rituximab, before they feel symptoms. Participants had already failed at least one other RA drug. The goal was to see if ultrasound could predict a relap…

This study looked at 13 adults with advanced colorectal cancer who were starting treatment with bevacizumab (Avastin) plus chemotherapy. The goal was to measure changes in artery stiffness and blood pressure over 4 months to better understand the drug's side effects on the heart …

This study tested whether a substance called tPA-PAI-1 in umbilical cord blood can predict brain bleeding in very premature infants (born before 30 weeks). Researchers measured this marker in 175 babies and compared those who later had a brain bleed with those who did not. The go…

This study looked at whether mental training can lower stress in anesthesia residents before they perform epidural pain relief for childbirth. 32 residents in training were randomly assigned to either do mental preparation or not, and their stress levels were measured. The goal w…

This study looked at whether the gut lining becomes more 'leaky' in women with anorexia nervosa due to severe malnutrition. Researchers measured intestinal permeability using sugar tests in 23 patients before and after refeeding, and compared them to 46 healthy controls. The goal…

This study looked at swallowing problems in 34 people with severe traumatic brain injury who were minimally conscious. Researchers used a special X-ray video to see how swallowing worked. The goal was to better understand these swallowing issues, not to test a treatment.

This study followed 80 people with pemphigus, a severe autoimmune blistering skin disease, who had previously taken part in a trial of the drug rituximab. Researchers wanted to see how safe the drug is over many years, how often the disease returns, and how the immune system chan…

This study looked at whether cannabis use harms sperm DNA in infertile men. Researchers compared 71 men who used cannabis to those who did not, measuring sperm chromosome abnormalities and other fertility markers. The goal was to understand how cannabis might affect male fertilit…

This study looked at whether women who have never given birth (nulliparous) feel more pain during IUD insertion than those who have (multiparous). Researchers measured pain right after insertion and 5 minutes later using a 0-10 scale. The goal is to help doctors better prepare pa…

This study looked at 140 colon cancer patients who had surgery and chemotherapy at Rouen University Hospital. Researchers wanted to see if patients who lived farther from the hospital waited longer to start chemotherapy after surgery. The goal was to find out if distance affects …

This study compared nurse practitioner monitoring to standard doctor monitoring for 207 people with colorectal cancer receiving intravenous chemotherapy. The goal was to see if nurses could provide equally safe and high-quality follow-up care. Results help determine if advanced p…

This small pilot study looked at whether aprepitant, a drug used for nausea, can lower a hormone called aldosterone in people with type 2 diabetes and high blood pressure. Five participants took either aprepitant or a placebo for two weeks, then switched. The goal was to understa…

This study tested whether a drug called ivabradine, which lowers heart rate, can improve the flexibility of arteries in healthy people. 20 volunteers aged 25-65 with a resting heart rate of 70 or higher took either ivabradine or a placebo for 8 days. Researchers measured artery s…

This study looked at a type of cell stress called endoplasmic reticulum stress in 53 adults having planned heart surgery with a heart-lung machine. Researchers measured stress markers in blood samples taken before and after the machine was used. The goal was to better understand …

This study explored whether being socially excluded (ostracized) affects the memory of children with ADHD. Twenty-four children completed memory tests before and after playing a computer game designed to make them feel left out. The goal was to understand how social experiences i…

This study looked at sleep quality in 42 adult intensive care patients. Researchers used a simple questionnaire to track sleep over time and compare sleep in the ICU versus a rehabilitation unit. The goal was to understand what affects sleep and whether moving to a rehab unit hel…

This study measured how stiff the heart muscle is during planned aortic valve replacement surgery for aortic stenosis. Researchers compared stiffness in 98 patients with aortic stenosis to a reference group having bypass surgery. The goal was to see if the extra pressure from aor…

This study explored whether specific gene variations are linked to suicide attempts in teenagers. Researchers compared the DNA of 250 adolescents, some who had attempted suicide and some who had not. The goal was to identify genetic risk factors that might help predict and preven…

This study looked at whether insomnia affects pain sensitivity in people with Irritable Bowel Syndrome (IBS). Researchers measured pain thresholds in 70 participants, including IBS patients with and without insomnia, healthy volunteers, and people with insomnia alone. The goal wa…

This study looked at how certain genes are turned on in blood cells of people with hereditary bradykinetic angioedema, a rare condition that causes sudden swelling. Researchers compared 30 patients to healthy volunteers to learn more about inflammation and blood vessel health. Th…

This study looked at 196 adults with septic shock in intensive care to see if a blood test measuring immature platelets could predict their risk of death or organ failure at 28 days. The goal was to find a cheap, routine test to identify high-risk patients early. The study did no…

This study looked at 40 adults with operable pancreatic cancer to see if measuring tumor DNA in blood (from a vein in the arm and a vein near the liver) and in belly fluid during surgery can help predict how the disease will progress. The goal was to understand if these DNA level…

This study looked at whether information from a national health insurance card—such as past antibiotic use and hospital visits—can help predict if a person's urinary tract infection will be resistant to standard antibiotics. Over 1,100 adults with community-acquired urinary tract…

This study tested whether a gentle, non-invasive electrical stimulation under the chin could change how the brain controls swallowing. Ten healthy adults without swallowing problems received the stimulation while researchers measured brain signals and swallowing speed. The goal w…

This study looked at how to keep a hormone called ACTH stable in blood samples after collection. ACTH is hard to measure because it breaks down quickly. Researchers tested a substance called aprotinin in blood from 10 healthy adults to see if it helps preserve ACTH. The goal was …

This study looked at 103 adults with septic shock to see if a protein called VEGF-A is linked to how much fluid they retain. The goal was to better understand why patients with sepsis often develop fluid buildup, which can be harmful. Researchers measured VEGF-A levels and fluid …

This study tested a very small, specially shaped wire (lead) for heart pacing in 20 people getting a cardiac resynchronization device. The goal was to see if the lead could successfully pace the left side of the heart. The study focused on how well the lead worked and checked for…

This study looked at whether certain genetic changes in colon cancer tumors can help predict if the cancer will return after surgery. Researchers tested tumor tissue from 401 people with stage II or III colon cancer using a special method called QMPSF. The goal was to see if thes…

This study tested a new method using a single oral dose of cinacalcet to measure parathyroid hormone (PTH) suppression. It compared results from healthy adults and patients with primary hyperparathyroidism. The goal was to see if this simpler test could replace the standard intra…

This study looked at how anxious 300 adults felt before undergoing allergy tests. Researchers measured anxiety using a simple 0-to-10 scale and also checked for signs of depression. The goal was to better understand patient worries and how they might affect test results.

This study examined whether people with eating disorders have certain autoantibodies (immune proteins) that target appetite-regulating substances in the body. Researchers collected blood samples from 211 participants, including patients with anorexia, bulimia, or binge-eating dis…

This study looked at 5 families where a child has a developmental disorder with no known cause. Researchers analyzed the child's and parents' DNA to find new mutations unique to the child, then checked if those mutations were also present in the father's sperm. The goal was to be…

This study looked at 80 kidney transplant recipients to see if certain genetic variations affect how well the transplanted kidney works over time. Researchers focused on enzymes that produce substances called EETs, which help blood vessels stay healthy. The goal was to find genet…

This study looked at 99 healthy full-term newborns to count and classify ear shape differences. Doctors took photos and sorted each ear as normal or having an anomaly, then labeled anomalies as either deformities (caused by outside forces like position in the womb) or malformatio…

This study tested a program that combines a patient app with hospital coordination to see if it can shorten the time to get a TAVI procedure for aortic stenosis. Over 800 adults with severe aortic valve narrowing took part. The goal was to see if more patients could get treated w…

This study tested two methods of removing a breathing tube after digestive surgery to see which one helps patients breathe better. 208 adults having surgery lasting over an hour took part. One group had the tube removed the usual way, and the other had it removed while still conn…

This study looked at 60 adults on long-term dialysis to see if having shorter, more frequent sessions (2 hours, 6 times a week) is better than standard sessions (4 hours, 3 times a week) at preventing dangerous drops in blood flow to the legs during treatment. The goal was to fin…

This study looked at whether L-lysine, a common amino acid, can change levels of the hormones aldosterone and cortisol in healthy men. Twenty volunteers took L-lysine or a placebo for 13 days, then switched. The goal was to learn how the body controls these hormones, not to treat…

This study looked at whether a very strong steroid cream (clobetasol propionate) causes fluid retention in 30 adults with bullous pemphigoid, a blistering skin condition. Researchers measured changes in body water using a special scale (bioimpedance) over 30 days. The goal was to…

This study looked at how the spine and pelvis move when people walk, using a special motion-capture system. 36 healthy men aged 20-40 walked normally and while wearing a corset that changed their posture. The goal was to see if this system could detect changes in balance, which m…

This study looked at how the drug cladribine affects the immune system in people with multiple sclerosis (MS). Researchers analyzed blood samples from 77 participants, including healthy donors and MS patients at different stages. The goal was to better understand the drug's anti-…

This study looked at 27 adults in intensive care to understand the inflammation behind macrophage activation syndrome (MAS) triggered by bacterial sepsis. MAS is a serious condition with a high death rate, and current treatments are not well-defined. By measuring specific inflamm…

This study examined how antibiotics given for urinary tract infections (UTIs) can change the bacteria living in the gut. Researchers collected stool samples from 61 hospitalized adults before, during, and after antibiotic treatment to track the rise of antibiotic-resistant bacter…

This completed study looked at how eating disorders, like anorexia and bulimia, impact blood sugar levels in women aged 18-40 with type 1 diabetes. Researchers compared glucose control between those with and without eating disorders using continuous glucose monitors. The goal was…

This study looked at whether a surgery called STARR, which helps people with severe constipation caused by a rectocele or intussusception, also damages the anal sphincter. Nine adults who had the surgery were tested before and three months after using a special balloon probe (End…

This study looked at families with at least two members diagnosed with Alzheimer's before age 65. Researchers searched for new genes that might cause the disease, beyond the three already known. The goal was to better understand the biology of Alzheimer's and improve genetic test…

This study looked at the bacteria living in the urine of 108 women, some with urinary tract infections (UTIs) and some healthy. Researchers used advanced DNA testing to find bacteria that standard lab tests miss. The goal was to learn how changes in the bladder's bacterial commun…

This study tested a web platform designed for people with mild memory loss or early dementia and their caregivers. The platform offers social networks, activities, and health tips to improve quality of life and help them live at home longer. 48 pairs (patient and caregiver) used …

This study looked at whether regular check-ins by a nurse could catch early signs of rheumatoid arthritis (RA) returning in patients taking the drug rituximab. 51 adults with RA who were in remission or had low disease activity took part. The idea was that nurse monitoring might …

This study tested whether early changes in blood markers (like CEA and tumor DNA) can predict if chemotherapy is working for people with metastatic colorectal cancer. 74 patients were followed for 3 months. The goal was to see if these blood tests could replace or supplement stan…

This study looked at whether proteins in the blood can help screen for colorectal cancer. Researchers tested blood samples from 350 people aged 50 and older who were already scheduled for a colonoscopy. The goal was to see if certain protein markers could reliably detect advanced…

This study looked at whether adding glutamine to the feedings of premature babies helps their stomachs empty faster and reduces the time they need IV nutrition. Forty stable preterm infants received either glutamine-enriched or standard feedings. Researchers measured stomach empt…

This study looked at how common gut inflammation and a 'leaky gut' are in blood cancer patients admitted to the ICU with sepsis or septic shock. Researchers measured markers of gut damage in 80 patients to better understand this often-overlooked problem. The goal was to gather kn…

This study reviewed medical records and MRI scans of 52 adults with Crohn's disease who had anal fistulas and were treated with biologic drugs. Researchers wanted to see how the fistulas looked on MRI at the start of treatment and again after one and three years. The goal was to …

This study aimed to determine the normal range of certain heart tissue measurements (T1, T2, and T2* relaxation times) using MRI in healthy adults. A total of 175 volunteers aged 18 to 69 participated. The results provide a baseline to help doctors better identify abnormal heart …

This study followed 26 adults with Anderson-Fabry disease to see how their heart tissue changes over time using a special MRI technique called T1 mapping. Some participants were already taking the enzyme replacement therapy Replagal®, while others were not. The goal was to learn …

This study looked at whether having a mix of certain gene changes can raise the risk of colorectal cancer more than any single change alone. Researchers compared 700 patients with strong family history or early-onset cancer to 350 healthy people. The goal is to better identify hi…

This study looked at 56 people who had surgery for colon cancer that had not spread. Researchers wanted to see if the number and type of immune cells inside the tumor could help predict which patients might have a recurrence. They analyzed blood samples and tumor tissue to unders…

This study looked at how fructose, a common sugar, affects anxiety and mood in healthy young men. Researchers compared those with and without fructose malabsorption (trouble digesting fructose) to see if gut bacteria play a role. The goal was to understand the link between diet, …

This study looked at a recently discovered protein called 26RFa, which may be linked to hunger, blood sugar, and obesity. Researchers measured its levels in 62 obese women (some with type 2 diabetes) before and after weight-loss surgery, and compared them to healthy volunteers. T…

This study examined 22 people with early-stage lung cancer to see if immune cells in the blood match those inside tumors. Researchers used advanced cell analysis to create a detailed immune profile. The goal was to find a simple blood marker that could help doctors monitor the im…