University Hospital, Rouen

This study tested whether a different dialysis schedule could help protect the legs and feet of people with kidney failure. It compared the standard schedule (4 hours, 3 times a week) with a daily schedule (2 hours, 6 times a week) in 60 patients. The goal was to see which method…

This study tested if a personalized plan created during a pharmacist interview could help control how long patients take strong opioid painkillers for non-cancer pain. It involved 100 adults hospitalized for musculoskeletal pain who were starting this type of medication. The goal…

This study compared two surgical techniques for treating deep endometriosis that grows into the rectum. Researchers wanted to know if removing a section of the colon and rectum causes more long-term bowel and bladder problems than a more conservative surgery that just removes the…

This small pilot study tested a new, very thin wire designed to improve a heart failure treatment called Cardiac Resynchronization Therapy (CRT). The study involved 39 patients who needed a CRT device to help their heart pump more effectively. Researchers checked if this new wire…

This study tested whether stimulating three different areas of the heart (instead of the standard two) could improve outcomes for people with heart failure who receive a special pacemaker called CRT. Researchers compared the new triple-site approach against standard therapy in 36…

This study tested a program designed to reduce the waiting time for a critical heart valve procedure called TAVI. It combined online patient education tools with changes to hospital coordination. The goal was to see if this approach could get more patients their needed treatment …

This study compared two approaches for managing rectal endometriosis in women not planning pregnancy: continuous hormone therapy versus curative surgery. Researchers followed 78 women aged 35-50 for two years to see which treatment led to better digestive function and quality of …

This study tested if specially trained nurse practitioners could monitor patients with colorectal cancer during their intravenous chemotherapy as safely and effectively as doctors. It involved 207 patients in France. The goal was to see if this new care model could free up doctor…

This study tested whether close, regular check-ups by a specialized nurse could spot the early return of rheumatoid arthritis symptoms in patients whose disease was well-controlled with the drug rituximab. The goal was to see if this nurse-led monitoring could detect a flare-up s…

This completed Phase 3 trial compared two different drug combinations to eliminate harmful antibodies that cause acquired hemophilia, a serious bleeding disorder. The study involved 110 adults with this condition and tested whether steroids with cyclophosphamide work better than …

This study tested a specialized nerve transfer surgery for adults with both vocal cords paralyzed in a closed position, causing voice and breathing problems. The surgery reroutes nerves from the diaphragm and tongue to try to restore movement to the laryngeal muscles that control…

This study tested two different settings on non-invasive breathing machines for patients hospitalized with acute, severe breathing failure. It focused on patients with obesity (BMI ≥ 30) who are at risk for sleep apnea or poor breathing while asleep. Researchers compared a standa…

This study tested whether a 12-week course of the drug dapagliflozin, which is usually for diabetes, could improve blood vessel health in people with chronic kidney disease who do not have diabetes. It involved 32 patients who were randomly assigned to receive either the drug or …

This study tested whether adding a special collagen-elastin matrix under a standard skin graft improves the final result. It involved 92 adults who needed skin grafts for wounds from trauma or surgery. Researchers compared grafts done with the matrix to grafts done alone, measuri…

This study tested whether adding hydroxychloroquine to standard treatment could improve blood vessel function in people with antiphospholipid syndrome (APS), a condition that causes dangerous blood clots. In this small, completed Phase 2 trial, 25 participants were randomly assig…

This study followed 80 patients with pemphigus, a serious autoimmune skin disease, who received rituximab treatment years earlier. Researchers tracked how many patients remained disease-free long-term and monitored for any delayed side effects. The goal was to understand the last…

This study tested whether giving chemotherapy before surgery improves outcomes for pancreatic cancer patients. It compared two different chemotherapy combinations given before surgery against the standard approach of surgery first, followed by chemotherapy. The goal was to see if…

This study compared two different chemotherapy combinations for people with advanced bladder cancer who need treatment before or after bladder removal surgery. Researchers tested whether a more intensive four-drug combination (HD-MVAC) works better than the standard two-drug comb…

This study tested whether a blood test could help diagnose pancreatic cancer. Researchers compared a new blood test that looks for cancer cells in the bloodstream against the standard biopsy procedure. The goal was to see if the blood test could provide accurate diagnosis with le…

This study tested a new blood marker called EM66 to see if it could better identify rare adrenal tumors (pheochromocytoma/paraganglioma) that cause severe high blood pressure. Researchers compared EM66 levels in 60 people: some with these tumors and others with ordinary high bloo…

This study tested whether a new medical device called EndoFLIP® could help doctors better diagnose anismus, a condition where muscles don't relax properly during bowel movements, causing constipation. Researchers enrolled 61 adults with chronic constipation to compare the new dev…

This study aimed to check how well different blood tests could detect COVID-19 antibodies. Researchers collected samples from 101 people, including COVID-19 patients and healthcare workers, to compare several commercial tests. The goal was to determine which tests were most accur…

This study tested whether spraying a drug called terlipressin into the airway before taking a biopsy could reduce bleeding. The goal was to allow doctors to safely take more tissue samples during a lung cancer check, which could lead to a more accurate diagnosis. The trial involv…

This study tested if a special type of CT scan could work as well as an MRI to check if heart muscle is still alive after a heart attack. Doctors need this information to decide if a procedure to reopen a blocked artery is worthwhile. The goal was to see if the CT scan could prov…

This study tested whether measuring certain proteins in the blood could help screen for colorectal cancer. It involved 350 adults aged 50 or older who were already scheduled for a colonoscopy. The goal was to see if a future blood test could be an easier screening option.

This study tested a tiny camera that doctors can insert into the lungs during a routine breathing tube exam. The camera takes microscopic pictures of lung tissue to help doctors identify different types of diffuse lung diseases more clearly. The goal is to improve diagnosis accur…

This study tested whether inhaling morphine through a mask works as well as getting it through an IV drip for treating severe pain in emergency rooms. Researchers compared the two methods in 226 adults with intense pain to see which provided faster, more effective relief. The goa…

This study tested whether applying a numbing medication called ropivacaine directly to skin graft donor sites could reduce pain after surgery. Researchers compared this approach to a standard saline solution in 58 adults who needed skin grafts smaller than a standard sheet of pap…

This study looked at whether it's better to give patients their pain medication prescription before or after outpatient surgery. It involved 200 adults having day surgery under general anesthesia. The goal was to see which timing leads to less pain at home after the operation.

This study tested a special website and app designed to support both people with early memory loss (mild cognitive impairment or dementia) and the family or friends who care for them. For 18 months, researchers compared 48 pairs of patients and caregivers, with some using the pla…

This study compared two different techniques for removing surgical drains after hip replacement surgery to find which method causes less pain for patients. Researchers worked with 87 patients who had hip replacements, measuring their pain during drain removal using a standard pai…

This study tested whether adjusting the shape of electrical currents in deep brain stimulation could help Parkinson's patients with walking and balance problems. Researchers worked with 19 patients who already had brain implants to see if directing the stimulation more precisely …

This small study explored whether a regular, moderate physical activity program could help reduce the chronic fatigue that affects many people with inflammatory bowel disease (IBD). Researchers worked with a few adult patients whose IBD was in remission to see if exercise could i…

This study tested whether a low FODMAP diet helps reduce symptoms of Irritable Bowel Syndrome (IBS). Researchers also checked if a simple breath test could predict which patients would benefit most from this diet. The goal was to see if dietary changes could provide relief for pe…

This study tested whether Botox injections into the rectum could help adults with fecal incontinence who haven't been helped by standard treatments. The goal was to see if the injections could reduce the number of bowel accidents and feelings of urgency, thereby improving quality…

This study tested whether adding a mobile app to the standard doctor's visit could help reduce anxiety in children before surgery. It involved 182 children aged 4 to 10 who were scheduled for an operation. Researchers compared anxiety levels between kids who used the app and thos…

This study tested a website created to help parents better understand and follow pain medication instructions after their child's outpatient surgery. It involved 200 children aged 2-12 and their families. The goal was to see if clearer online information could improve pain manage…

This study tested a new physical therapy program for women with stress urinary incontinence, which causes leaks during activities like coughing or laughing. Researchers wanted to see if supervised balance exercises performed on a soft foam surface could reduce the amount of urine…

This study tested if removing a patient's breathing tube using a specific 'positive pressure' technique could help prevent low oxygen levels after major abdominal surgery. Researchers compared this new method to the standard way of removing the tube in 208 adult patients. The goa…

This study aimed to understand if high levels of a protein called VEGF-A, which can make blood vessels leaky, are linked to fluid buildup in patients with septic shock. Researchers measured VEGF-A levels and tracked fluid balance in 103 adults with this severe condition during th…

This study aimed to improve the accuracy of a common blood test that measures a hormone called ACTH. Researchers tested how adding a stabilizing agent (aprotinin) affects ACTH levels in blood samples from 10 healthy volunteers. The goal was to understand the best way to handle bl…

This study aims to better understand what causes urinary tract infections (UTIs) by comparing the community of bacteria and chemicals in the urine of women who have UTIs to those who do not. Researchers enrolled 108 premenopausal women, some with a UTI and some healthy, to analyz…

This study looked at how antibiotics used to treat urinary tract infections (UTIs) might affect the good bacteria in your gut. Researchers collected stool samples from 61 hospitalized adults before and after their antibiotic treatment to see if the drugs caused unwanted changes. …

This study aimed to understand how developmental disorders might be passed from fathers to children. Researchers analyzed genetic material from 5 families where children had unexplained developmental issues. They compared children's DNA with both parents' DNA and specifically exa…

This study aimed to find a marker in umbilical cord blood that could predict which very premature babies are at highest risk for a serious brain bleed called intraventricular hemorrhage. Researchers measured levels of certain proteins and looked at genetic variations in 120 infan…

This study tested whether simple blood tests taken early in treatment could predict how well chemotherapy would work for people with advanced colorectal cancer. Researchers followed 74 patients receiving first-line chemotherapy to see if changes in certain cancer markers in their…

This study aimed to understand the biology of a rare inherited swelling disorder called hereditary bradykinetic angioedema. Researchers compared the activity of specific genes in immune cells (monocytes) between 30 patients with the condition and healthy volunteers. The goal was …

This study aimed to understand how often intestinal problems occur in people with blood cancers who are hospitalized in intensive care with severe infections (sepsis). Researchers measured specific markers of gut inflammation and damage in 80 patients to see if these issues are m…

This study aimed to see if measuring 'young' platelets in a routine blood test could help predict how sick a patient with severe sepsis might become. Researchers followed 196 adults admitted to intensive care with sepsis or septic shock. They checked if the level of these young p…

This study tested whether a mental preparation session could help reduce stress for anesthesia residents before they perform a common but high-pressure procedure: placing an epidural for a woman in labor. Thirty-two residents were randomly assigned to either receive the mental tr…

This study aimed to understand exactly how the drug cladribine works in people with multiple sclerosis (MS). Researchers tested blood cells from 77 MS patients and healthy donors in the lab to see how the drug affects the immune system and whether it might protect nerve cells. Th…

This study followed 108 children who were born very prematurely to see if specific speech therapy they received around age 3-4 helped their reading skills years later, at school age. Researchers measured reading speed and comprehension to understand if early language support has …

This study aimed to find out how common different ear shape variations are in healthy newborn babies in France. Doctors observed 99 full-term newborns, taking photos of their ears at birth and checking again at one year. The goal was to gather basic information to help understand…

This study aimed to find out if a very strong steroid cream used to treat bullous pemphigoid, a condition that causes large blisters, leads to fluid retention in the body. Researchers measured body water levels in 30 patients using a painless electrical device over 30 days of tre…

This study looked at whether using a specific, short-acting pain medication (remifentanil) for mothers during emergency C-sections for premature births is safe for the baby's first critical minutes. Researchers compared babies whose mothers received this medication to those whose…

This study aimed to see if a special type of MRI scan could measure how well a treatment works for the heart in people with Fabry disease. Researchers followed 26 patients, some receiving the treatment and some not, to track changes in their heart scans over time. The goal was to…

This study aimed to understand why some sepsis patients develop a dangerous immune system overreaction called macrophage activation syndrome, which has a high death rate. Researchers compared blood samples from 27 intensive care patients with this condition to those with regular …

This study tested whether lowering heart rate with a medication called ivabradine could improve the flexibility and health of arteries in healthy people. It involved 30 healthy volunteers aged 25-65 who took either the drug or a placebo for 8 days. Researchers measured changes in…

This study tested a new, objective method to check if a patient's skin is clean before surgery. Researchers compared a simple swab test (ATPmetry) to the usual method where a nurse just looks at the skin. The goal was to see if the swab test is reliable and could help standardize…

This study aimed to understand if sleep problems like insomnia are linked to increased gut pain sensitivity in people with Irritable Bowel Syndrome (IBS). Researchers compared pain thresholds in four groups: healthy people, people with only insomnia, people with only IBS, and peo…

This study aimed to understand how a common cancer drug (bevacizumab/Avastin) affects the heart and blood vessels in patients with advanced colorectal cancer. Researchers measured artery stiffness and blood pressure in 13 patients before and during treatment to see if these heart…

This study aimed to understand if moving patients from a busy intensive care unit (ICU) to a quieter, specialized recovery unit could improve their sleep. Researchers asked 42 adult ICU patients who had been hospitalized for over a week to complete a sleep quality questionnaire. …

This study aimed to understand how a specific rectal surgery (STARR procedure) affects the anal muscles' ability to control bowel movements. Researchers measured anal muscle function before and after surgery in 9 patients with severe constipation caused by a rectal bulge. The goa…

This study aimed to better understand lung diseases by looking directly at the smallest blood vessels in the lungs. Researchers used a special microscopic camera during a standard bronchoscopy procedure in 9 patients with either scleroderma or emphysema. The goal was to see how t…

This study aimed to understand how different types of brain damage affect a person's thinking, memory, and other mental skills. Researchers compared brain scans and detailed thinking tests from 346 people—some with brain injuries from strokes, tumors, or degenerative diseases, an…

This study aimed to understand if women who have never given birth experience more pain during IUD insertion than women who have. It involved 162 women who were getting an IUD. Researchers measured pain and anxiety during the procedure and checked in later to see if women were sa…

This study aimed to understand if immune cells in the blood match those inside lung tumors. Researchers studied 22 patients with early-stage, operable lung cancer to see if a simple blood test could help doctors monitor a patient's immune response. The goal was to gather knowledg…

This study aimed to understand why patients with severe sepsis or septic shock lose muscle mass, which is linked to worse outcomes. Researchers measured a specific protein (PTP1B) and a gut health marker (zonulin) in 52 patients to see if they were connected to muscle loss. The g…

This study aimed to understand if the body's own immune system might be involved in eating disorders. Researchers tested blood and stool samples from over 200 patients with conditions like anorexia and bulimia, comparing them to healthy volunteers. They were looking for specific …

This study aimed to understand how a specific type of cellular stress, called endoplasmic reticulum stress, changes in people during heart surgery using a heart-lung machine. Researchers measured stress markers in blood samples from 53 adults before and after their planned surger…

This study aimed to understand if measuring cancer DNA from different blood sources during pancreatic cancer surgery provides better information about the disease. Researchers collected blood from the arm and a specific liver vein, plus fluid from the abdomen, during surgery in 4…

This small, completed study aimed to understand how a supervised, gentle exercise program affects specific body chemicals and recovery in adults with anorexia nervosa who are undergoing nutritional treatment. It compared a group doing the exercise program to a group that did not,…

This study aimed to better understand swallowing problems in patients with severe traumatic brain injury who have altered consciousness. Researchers examined 34 patients using special swallowing tests and consciousness assessments. The goal was to identify patterns and connection…

This study looked at whether cannabis use affects sperm quality in men experiencing infertility. Researchers compared 71 infertile men who used cannabis at least weekly to similar men who did not use it. They measured various aspects of sperm health to understand if cannabis migh…

This study aimed to understand if fructose, a common sugar, affects anxiety and depression by changing gut bacteria. It compared 56 healthy young men, some with and some without fructose malabsorption, to see if their gut bacteria and feelings differed. The goal was to gather kno…

This study aimed to understand how the body's immune system, specifically T-cells, responds to COVID-19 during and after infection. Researchers measured T-cell activity and antibody levels in 51 hospitalized COVID-19 patients and healthy hospital staff. The goal was to learn how …

This study aimed to understand how often patients with bullous pemphigoid, a painful blistering skin disease, experience sleep problems. Researchers compared 122 patients with the condition to a control group using a standard sleep questionnaire. The goal was to measure the preva…

This study aimed to find out if two different types of blood tests could predict whether colon cancer would come back after surgery. Researchers followed 216 patients who had their cancer surgically removed. They compared tests that look for tiny pieces of cancer DNA versus whole…

This study aimed to understand the role of a brain chemical called 26RFa, which is linked to hunger, in obesity and type 2 diabetes. Researchers measured levels of this hormone in 62 obese women (some with diabetes, some without) before and after weight-loss surgery, and compared…

This study aimed to understand how fistulas (painful tunnels near the anus) in Crohn's disease change over time when treated with biologic medications. Researchers used MRI scans to look at the internal healing of these hard-to-treat wounds in 52 adult patients. The goal was to g…

This study aimed to understand how aortic valve stenosis affects heart muscle stiffness. Researchers measured stiffness directly on the heart during surgery in 98 patients—some having valve replacement and others having bypass surgery. They used a special ultrasound technique to …

This study aimed to understand what makes pemphigus patients feel vulnerable during their illness journey. Researchers interviewed 48 patients to learn about their psychological experiences, how they cope with diagnosis, and their interactions with healthcare providers. The goal …

This small study aimed to understand if a specific brain chemical pathway contributes to high blood pressure in people with type 2 diabetes. Researchers tested if a drug called aprepitant (normally used for nausea) could change levels of key hormones like aldosterone in five diab…