University Hospital, Rouen

This study looked at how well the MenBVac vaccine protects children against a specific type of meningitis B bacteria. Researchers measured the immune response in 218 children who had already received five doses of the vaccine. The goal was to see if the children had enough antibo…

This study tested whether a fourth dose of the MenBVac vaccine boosts protection against meningitis B in children. Researchers measured immune responses in 120 children before and after the booster. The goal was to see if the vaccine maintains protective antibody levels over time…

This study looked at 117 children aged 4-8 who had received four doses of the MenBVac vaccine against meningitis B. Researchers measured how many still had protective antibodies four years after the last dose. The goal was to see if the vaccine's immunity lasts over time.

This study tested whether briefly stopping blood flow to the aorta before surgery (called ischemic pre-conditioning) could reduce complications in people undergoing open repair of a thoracoabdominal aortic aneurysm. 65 patients were randomly assigned to receive either the pre-con…

This study tested whether a personalized talk with a pharmacist could help people take opioid painkillers for a shorter time. 100 adults with non-cancer pain in a hospital rheumatology ward took part. The goal was to see if the pharmacist's advice could keep opioid use closer to …

This study looked at whether giving kidney transplant patients a lower dose of the drug cyclosporine could protect their kidney function over time. 208 patients who were at least one year post-transplant and on stable medications took part. The goal was to balance preventing orga…

This study followed 80 patients with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. Researchers wanted to see how safe and effective rituximab (a drug that targets certain immune cells) is over the long term, compared to standard h…

This pilot study tested a new, very small lead (under 2 French) designed to improve cardiac resynchronization therapy (CRT) for heart failure. In 20 patients getting a standard CRT device, doctors temporarily placed the new lead to see if it could pace the heart's left ventricle …

This study followed 26 people with Anderson-Fabry disease, some taking the enzyme replacement drug Replagal® and some not, to see how their hearts changed over two years. Researchers used special MRI scans to measure heart tissue relaxation time, which may indicate early damage. …

This study compared two surgical methods for treating a burst section of the colon caused by diverticulitis, a condition that leads to severe abdominal infection. 102 adults with this infection were randomly assigned to either a traditional two-step surgery (Hartmann procedure) o…

This study tested whether a single cycle of rituximab can control bullous pemphigoid, a severe blistering skin condition. Eighteen adults with steroid-dependent or relapsing disease were enrolled. Researchers checked disease control weekly for a month and then monthly for two yea…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study tested whether ultrasound could detect signs of rheumatoid arthritis (RA) relapse before symptoms appear in patients treated with rituximab. Thirty adults with RA who had not responded to at least one TNF-blocking drug were included. Researchers used ultrasound to meas…

This study looked at whether using a noninvasive ventilation mask (NIV) can help patients with chronic respiratory failure wean off mechanical ventilation more successfully. 205 patients who had been on a breathing tube for at least 48 hours and failed a spontaneous breathing tes…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This phase II trial tested a combination of two chemotherapy drugs, cisplatin and irinotecan, given weekly along with radiation therapy for patients with locally advanced esophageal cancer. The study enrolled 43 participants and aimed to see how many had no detectable tumor after…

This completed Phase 2 study tested a combination of chemotherapy (FOLFIRI) and radiation with 5-fluorouracil in 63 patients with gastric cancer. The treatment was given either before or after surgery to remove the tumor. The goal was to see if this approach is feasible and less …

This study tested two drug combinations in 110 adults with acquired hemophilia, a rare condition where the immune system attacks clotting factors, causing severe bleeding. One group received steroids plus cyclophosphamide, the other steroids plus rituximab. The goal was to see wh…

This study tested whether adding a collagen-elastin dermal matrix to standard skin grafts improves skin flexibility and reduces scarring. 92 adults with skin loss from injury or surgery received either a graft with the matrix or a graft alone. The main goal was to measure skin fo…

This study tested whether giving chemotherapy before surgery (neoadjuvant chemo) helps people with resectable pancreatic cancer live longer. 153 patients were randomly assigned to either standard surgery followed by chemo, or one of two chemo regimens (FOLFOX or FOLFIRINOX) befor…

This pilot study tested a very small, specially shaped heart lead (less than 2 French) in 39 adults getting a cardiac resynchronization therapy device. The goal was to see if the lead could successfully pace the left ventricle from two distant spots. Researchers measured pacing s…

This study looked at whether a 12-week course of dapagliflozin can improve blood vessel function in people with chronic kidney disease. 32 participants took the drug, and researchers measured changes in artery health using ultrasound. The goal was to see if the drug could help co…

This study tested whether directional deep brain stimulation (DBS) can improve walking and balance problems in people with Parkinson's disease. Nineteen patients who already had DBS electrodes implanted took part. Researchers compared different stimulation settings to see which h…

This study looked at two ways to manage rectal endometriosis in women aged 35-50 who do not plan to get pregnant. One group received hormone therapy for 24 months, while the other had surgery followed by hormones. The goal was to see which approach leads to better digestive funct…

This study tested a surgery that reconnects nerves in the throat to help people with both vocal cords paralyzed. The goal was to improve breathing and voice without causing swallowing problems. Four adults who had not gotten good results from earlier treatments took part. Results…

This study looked at 60 women with deep endometriosis in the rectum to compare two surgical approaches: removing the affected part of the rectum versus just cutting out the endometriosis nodules. The goal was to see which method leads to fewer long-term bowel and bladder problems…

This study tested two different chemotherapy drug combinations in 500 people with advanced bladder cancer that had not spread to other organs. The goal was to see which treatment worked better at stopping the cancer from coming back after surgery. Participants received either gem…

This study tested whether a blood test called exome sequencing can find genetic causes of autism better than standard care. Researchers studied 300 people with autism to see if the test could identify risk genes. The goal is to improve diagnosis and help families understand the b…

This study tested a new way to diagnose COVID-19 using a saliva sample instead of the standard nose/throat swab. Researchers compared the new method to the usual one in 130 adults at a hospital in France. The goal was to see if the saliva test works just as well, which could make…

This study tested a blood test called the Basophil Activation Test (BAT) to see if it can accurately diagnose peanut and egg allergies in children. Currently, the gold standard is an oral food challenge, which can cause severe allergic reactions. The researchers compared BAT resu…

This study tested a special microscope on a thin probe (confocal endo-microscopy) that doctors can use during a bronchoscopy to look at lung nodules up close. The goal was to see if it can help tell whether a nodule is cancer or not, right then and there. 120 adults with a lung n…

This study looked at whether a new blood marker called EM66 can help doctors tell the difference between high blood pressure caused by rare adrenal tumors (pheochromocytoma or paraganglioma) and regular high blood pressure. Researchers measured EM66 levels in 60 adults with eithe…

This study tested whether a new device called EndoFLIP can better diagnose anismus, a condition where the anal muscles don't relax properly during bowel movements, causing severe constipation. Researchers measured anal stretchiness in 61 patients with chronic constipation and com…

This study tested whether spraying a drug called terlipressin into the airways before taking biopsy samples can reduce bleeding. The goal was to allow doctors to safely take more tissue samples, which could improve the chances of diagnosing lung cancer. The trial involved 130 adu…

This study tested two different methods of removing surgical drains after total hip replacement to see which one hurts less. 87 patients rated their pain on a scale from 0 to 10 right after drain removal. Researchers also checked for bruising afterward. The goal is to make a rout…

This study compared two breathing devices—CPAP and bilevel ventilation—in people with severe fluid buildup in the lungs (pulmonary edema). The goal was to see which device improves breathing faster. Participants were adults in respiratory distress. The results could help doctors …

This study looked at whether treating an overgrowth of bacteria in the small intestine (SIBO) with antibiotics could help people who have trouble controlling gas. Sixteen adults with gas incontinence for over 3 months took part. The goal was to see if antibiotics could reduce the…

This study tested whether a non-invasive brain stimulation technique called rTMS could help people with psychogenic paralysis (paralysis with no physical cause). 66 participants received two sessions of either real or sham rTMS over two days. The main goal was to see if paralysis…

This study tested whether using two different nerve blocks together, instead of just one, can reduce the amount of strong painkillers (opioids) needed after lung surgery. 112 adults scheduled for video-assisted thoracoscopic surgery received either a single block or a double bloc…

This study tested a web platform designed for people with mild cognitive impairment or mild to moderate dementia and their primary caregivers. The platform offers social networks, activities, and games to improve quality of life and help them stay in the community longer. Researc…

This study tested whether avoiding morphine during heart surgery could reduce common complications like breathing problems, confusion, and gut issues. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia or a combinat…

This study tested whether breathing in morphine works as well as getting it through an IV for quickly treating severe pain in the emergency department. 226 adults with intense pain were randomly assigned to receive either inhaled morphine plus a placebo IV, or IV morphine plus a …

This study looked at whether a low FODMAP diet can improve digestive symptoms in people with irritable bowel syndrome (IBS). Researchers tested 112 adults with IBS, some of whom had a positive breath test for fructose intolerance. The goal was to see if avoiding certain carbohydr…

This study tested whether a program of reflex postural control exercises on a foam surface can reduce stress urinary incontinence in women. 88 women participated, doing supervised exercises and a home program. The main goal was to see if urine leakage decreased after the program.

This study tested whether applying the numbing medicine ropivacaine to a skin graft donor site can lower pain after surgery. 58 adults who needed a small skin graft were randomly assigned to get either ropivacaine or a saltwater solution on their wound dressing. The main goal was…

This study tested whether injecting botulinum toxin (like Botox) into the rectum can reduce episodes of accidental bowel leakage and urgent bathroom needs in people with fecal incontinence. The trial involved 200 adults whose condition did not improve with standard treatments. Th…

This study looked at 91 sepsis patients in intensive care to create a computer model that predicts the right dose of the antibiotic piperacillin/tazobactam. Researchers took blood samples at different times to measure drug levels. The goal was to develop a tool that helps doctors…

This study checked if a French version of a sleep questionnaire works well for patients in intensive care. Researchers asked 190 adults who were awake and able to answer questions about their sleep quality. The goal is to give doctors a simple way to spot sleep problems and relat…

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This completed study looked at how a natural chemical called endothelin-1 affects the widening of arteries in response to increased blood flow. Eight healthy young men received drugs that block specific receptors for endothelin-1 to see how their arteries reacted. The goal was to…

This study looked at 200 men with sperm abnormalities to see if vacuoles (tiny holes) in the sperm head are linked to DNA damage. Researchers used high-powered microscopes and genetic tests to measure vacuole size and chromosome errors. The goal is to help doctors pick healthier …

This study looked at whether suctioning the windpipe (tracheal suction) during removal of a breathing tube affects lung volume in critically ill patients. Researchers measured lung volume changes in 60 ICU patients before and after extubation, comparing those who received suction…

This study looked at whether magnetic stimulation of nerves in the lower back can change how the colon moves. It included 30 people: healthy volunteers, and patients with constipation or fecal incontinence. The goal was to understand the effect, not to treat the condition.

This study looked at two breathing treatments—high-flow oxygen and non-invasive ventilation—in 16 adults with sudden breathing failure from pneumonia. The goal was to see which one better opens up the lungs. The results showed no major difference in lung opening, though non-invas…

This study looked at whether measuring certain substances in the cord blood of very premature babies (born before 30 weeks) can predict if they will develop bleeding in the brain. Researchers measured levels of a complex called t-PA-PAI-1 and other markers in 175 infants. The goa…

This study looked at how sacral nerve stimulation (SNS) affects the nerves in the gut of people with fecal incontinence. Researchers collected tissue samples from 37 patients who had a stimulator implanted. They wanted to see if the stimulation changes certain nerve cells. The go…

This study looked at a thin layer inside blood vessels called the glycocalyx in 78 adults having major abdominal surgery. Researchers used a special camera to measure changes in this layer during and after surgery. The goal was to see if tracking glycocalyx thickness could help d…

This study looked at 232 people with cerebral venous thrombosis, a rare stroke that mainly affects young women. Researchers took blood samples at several time points to measure markers of clot formation and breakdown. They wanted to see if these markers relate to how the disease …

This study looked at whether pregnant women would accept using a vibrating relaxation tool to help with pain. 32 pregnant women were asked to use the tool at least twice. The goal was to see if this approach is worth studying further, not to prove it works.

This study looked at whether difficulty digesting fructose (a sugar found in many foods) is linked to anxiety and changes in gut bacteria. Researchers compared 56 healthy young men who either absorb fructose normally or have trouble absorbing it. The goal was to see if fructose m…

This study tracked 300 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVI) to see how long they stayed in the hospital and why some stayed longer than 3 days. The goal was to find out what factors, like needing a blood transfusion or a…

This study looked at 29 adults with severe bee or wasp sting allergies to understand why a fast, one-day desensitization treatment is safe. Researchers measured changes in immune cells (basophils and T cells) before and after the treatment. The goal was to learn the mechanism, no…

This study looked at 140 patients who had colon cancer surgery and chemotherapy at Rouen University Hospital. The goal was to see if living farther from the hospital caused a longer wait to start chemotherapy after surgery. The findings could help improve care for patients who li…

This study looked at 338 adults having knee or hip surgery with a femoral nerve catheter for pain relief. Half had the catheter tunneled a short distance under the skin, the other half did not. Researchers checked the catheter tip for bacteria after removal to see if tunneling lo…

This study looked at two different methods for measuring balance during walking: a force plate and a 3D motion-capture system. Fifty healthy adults walked normally and quickly while both tools recorded their movements. The goal was to see which method gives more consistent result…

This study tested whether a gynecological exam done while lying on the side (lateral decubitus) works well enough to be a regular option. Over 500 women who needed a pelvic exam tried this position. The goal was to see if it is effective and more comfortable, which could help mor…

This study looked at whether being socially excluded (ostracized) affects the memory of children with ADHD. Twenty-four kids played a computer ball-tossing game where they were eventually left out, and their memory was tested before and after. The goal was to see if emotional dys…

This study looked at whether certain gene variations affect how well a transplanted kidney works over time. Researchers checked 80 kidney transplant recipients for specific gene markers and measured their kidney function for up to three years. The goal was to find clues that coul…

This study examined 5 families where a child has a developmental disorder with no known cause. Researchers analyzed the genomes of the child and both parents, then checked the father's sperm for the same new mutations found in the child. The goal was to see how often these mutati…

This study looked at a type of cell stress called endoplasmic reticulum (ER) stress in 53 adults having planned heart surgery with a heart-lung machine. The goal was to measure changes in ER stress markers before and after the machine was used. By studying these markers, research…

This study tested whether a heart-rate-lowering drug called ivabradine can improve the flexibility of arteries in healthy people. 20 volunteers with a resting heart rate of 70 or higher took either the drug or a placebo for 8 days. Researchers measured artery stiffness and other …

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study tested a special camera system (Vicon) to see how a curved spine (kyphosis) changes the way people walk. 36 healthy men wore a corset to temporarily create a curved spine, and the cameras measured their balance and movement. The goal was to see if this system could det…

This study looked at whether a surgery called STARR, used to treat severe constipation caused by a rectocele or intussusception, affects the anal sphincter's ability to stretch and hold. Nine patients were tested before and 3 months after surgery using a special balloon device (E…

This completed study tested whether high-resolution manometry (using many electronic sensors) can measure anorectal function better than traditional methods. It included 60 participants: people with fecal incontinence and healthy controls. The goal was to improve how doctors asse…

This study looked at whether a mild electrical stimulation applied under the chin (transcutaneous electrical stimulation) can change how the brain controls swallowing. Ten healthy adults without swallowing problems took part. The goal was to see if this non-invasive technique cou…

This study looked at whether certain genetic variations are more common in teenagers who have attempted suicide. Researchers analyzed DNA from 250 teens (half who attempted suicide, half who did not) to see if specific genes linked to brain function might increase risk. The goal …

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers took blood samples early in treatment to measure three markers: CEA, circulating tumor DNA, and total cell-free DNA. The goal was to see if early changes in these marke…

This study tests whether a single dose of the drug cinacalcet can be used to measure how well the body suppresses parathyroid hormone (PTH). Researchers compare this pill-based test to the standard intravenous calcium test in healthy adults, and also compare results between healt…

This study aimed to find normal values for heart tissue measurements using MRI in 175 healthy volunteers aged 18-69. By establishing these baselines, doctors can better detect abnormalities like scarring or iron buildup in future patients. No treatment or intervention was given—o…

This study looked at whether L-lysine, a common amino acid, changes levels of aldosterone and cortisol—hormones that control salt balance and stress. Twenty healthy men took L-lysine or a placebo for 13 days, then switched. Researchers measured hormone responses to standing, a dr…

This study looked at whether information from national health insurance cards—like past antibiotic use and hospital stays—can predict if a person's urinary tract infection will be resistant to common antibiotics. Researchers analyzed data from over 1,100 patients with community-a…

This study followed 56 patients who had surgery for non-metastatic colon cancer to see if the number and type of immune cells in their tumors could predict whether the cancer would come back. Researchers analyzed both blood samples and tumor tissue for various immune markers. The…

This study looked at whether regular nurse check-ins could spot the return of rheumatoid arthritis symptoms sooner than standard doctor visits. 51 adults with controlled arthritis on rituximab took part. The goal was to see if nurses could detect early signs of a flare, potential…

This study looked at whether a genetic test called QMPSF can help predict if stage II or III colon cancer will come back after surgery. Researchers analyzed tumor tissue from 401 patients for specific DNA changes. The goal was to see if these genetic markers are linked to cancer …

This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to…

This study looked at how eating disorders, like anorexia or bulimia, impact blood sugar levels in women with type 1 diabetes. Researchers compared glucose control between those with and without eating disorders. The goal was to better understand these risks and improve screening …

This study checked whether the gut lining becomes leaky in women with anorexia nervosa due to severe starvation. Researchers measured sugar levels in urine after drinking special sugars to test intestinal permeability in 23 patients and compared them to 46 healthy controls. They …

This study measured anxiety in 300 adults before they underwent allergy testing. Researchers used a simple 0-to-10 scale and a questionnaire to gauge how anxious patients felt. The goal was to better understand what affects a patient's experience and how anxiety might influence t…

This study tested whether giving glutamine (a dietary supplement) to premature babies helps them digest food faster and reduces the time they need IV nutrition. Forty babies born at 30-33 weeks and free of acute illness were randomly assigned to receive either glutamine or a cont…

This study looked at whether using remifentanil, a fast-acting opioid, during general anesthesia for emergency C-sections affects how well premature babies adapt after birth. Researchers compared two groups of mothers and their premature babies: one group received remifentanil, t…

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This study looked at 200 adults having day surgery with general anesthesia. One group received their pain medication prescription before surgery, the other after. Researchers tracked how many people had moderate-to-severe pain at home within 24 hours. The goal was to see if givin…

This study looked at whether women who have never given birth (nulliparous) feel more pain during IUD insertion than those who have (multiparous). 162 women rated their pain on a 0-10 scale at different steps of the procedure. The goal is to better understand and manage pain for …

This study looked at how antibiotics used to treat urinary tract infections (UTIs) affect the bacteria in the gut. Researchers collected stool samples from 61 hospitalized patients before and after antibiotic treatment to see if resistant bacteria increased. The goal was to under…

This study looked at swallowing problems in 34 patients with severe traumatic brain injury who are minimally conscious. Researchers used a special X-ray test called videofluoroscopy to see how swallowing works. The goal was to better understand these swallowing disorders, which c…

This study tested a program to help people with severe aortic stenosis get a TAVI heart valve procedure faster. The program included a website and booklet for patients, plus better coordination among hospital teams. Researchers measured whether more patients could be treated with…

This study looked at 99 healthy full-term newborns to see how many had ear shape differences. Doctors took photos and classified each ear as normal or having an anomaly. The goal was to better understand how common these differences are and how to categorize them.

This study looked at how the drug cladribine affects the immune system in people with multiple sclerosis (MS). Researchers analyzed blood samples from 77 MS patients and healthy donors to understand the drug's anti-inflammatory effects. The goal was to learn more about how cladri…

This study tested two methods of removing a breathing tube after digestive surgery to see which one helps patients breathe better. 208 adults having surgery lasting over an hour took part. One group had the tube removed the usual way, and the other had it removed while still conn…

This study looked at whether measuring immature platelets in the blood can help predict how septic shock patients will fare. Researchers followed 196 intensive care patients and checked if the immature platelet fraction at admission was linked to death or organ failure at 28 days…

This study looked at how stable ACTH, a hormone that helps control cortisol, is in blood samples. Researchers took blood from 10 healthy adults and measured ACTH levels to see how factors like temperature and time affect results. The goal is to improve the accuracy of ACTH blood …

This study looked at 48 adults with pemphigus, a rare blistering skin disease, to understand what makes them feel vulnerable during their illness. Researchers used interviews and questionnaires to explore factors like misdiagnosis, differences in how patients and doctors see dise…

This study looked at whether a nurse practitioner can safely monitor people with colorectal cancer who are getting intravenous chemotherapy, compared to a doctor. About 207 adults took part. The goal was to see if the number of serious side effects and quality of life were simila…

This completed study looked at how different types of brain damage—from strokes, tumors, infections, or degenerative diseases—affect thinking and memory. Researchers used brain scans (MRI) and cognitive tests in 346 patients and healthy volunteers to map which brain areas are res…

This study measured fluid retention in 30 people with bullous pemphigoid who were treated with a strong steroid cream (clobetasol propionate). Researchers used bioimpedance to track changes in body water over 30 days. The goal was to understand if the cream causes fluid buildup a…

This study looked at 103 adults with septic shock to see if a protein called VEGF-A is linked to how much extra fluid their bodies hold. Septic shock causes blood vessels to leak, leading to dangerous fluid buildup. Researchers measured VEGF-A levels and fluid balance to better u…

This study looked at whether cannabis use affects sperm quality in infertile men. Researchers compared sperm samples from 71 men who used cannabis and those who did not. They measured sperm DNA health and other factors to see if cannabis might be linked to fertility problems.

This study aimed to find out if people with eating disorders have unusual antibodies that attack natural chemicals controlling appetite. Researchers collected blood samples from 211 participants, including patients with anorexia, bulimia, or binge eating, and healthy volunteers. …

This completed study looked at 52 adults with septic shock to see if a protein called PTP1B and gut barrier changes are linked to muscle loss. Researchers took blood samples and used ultrasound to measure muscle. The goal was to gather knowledge, not to test a treatment.

This study looked at whether proteins in the blood can help screen for colorectal cancer. Researchers tested blood samples from 350 people aged 50 and older who were already scheduled for a colonoscopy. The goal was to see if certain protein markers could reliably detect advanced…

This study looked at 40 patients with pancreatic cancer to measure circulating tumor DNA (ctDNA) in blood from a vein near the pancreas and in the arm, as well as in fluid from the belly, during surgery. The goal was to see if these DNA levels could help predict how the disease p…

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study looked at how bevacizumab, a drug used to treat advanced colorectal cancer, affects the stiffness of arteries. Researchers measured artery stiffness in 13 patients before and after 4 months of treatment. The goal was to better understand the drug's cardiovascular side …

This study looked at gene activity in immune cells from 30 people with hereditary angioedema and healthy volunteers. The goal was to see if certain receptors on monocytes are linked to inflammation and blood vessel problems. No treatment was given; the study was purely observatio…

This study looked at whether insomnia affects pain sensitivity in people with Irritable Bowel Syndrome (IBS). Researchers measured pain thresholds using a barostat procedure in 70 participants, including IBS patients with and without insomnia, healthy volunteers, and people with …

This study looked at 27 adults in intensive care to understand the inflammatory profile of macrophage activation syndrome caused by bacterial sepsis. Researchers measured specific immune markers in blood samples taken over five days. The goal is to gather knowledge that could lea…

This completed study looked at how common gut inflammation and leaky gut are in 80 adults with blood cancer who were in intensive care for sepsis or septic shock. Researchers measured two markers—calprotectin in stool and zonulin in blood—to better understand intestinal dysfuncti…

This study looked at how T-cells, a key part of the immune system, respond to the COVID-19 virus in 51 people—hospitalized patients and healthy hospital staff. Researchers measured T-cell activity at several time points using a blood test called ELISPOT. The goal was to better un…

This study looked at 216 people with stage II or III colorectal cancer who had surgery to remove their tumor. Researchers compared two blood tests—one that looks for tumor DNA and another that looks for tumor cells—to see which better predicts if the cancer will come back within …

This study looked at the bacteria living in the bladder (urinary microbiota) of 108 women, some with urinary tract infections (UTIs) and some healthy. Researchers used advanced DNA sequencing to find bacteria that standard lab tests miss. The goal was to understand how changes in…

This study tested a new method called ATPmetry to check if patients' skin is clean before surgery. Currently, nurses look at the skin to decide if it's clean, but this can be unreliable. The study involved 200 patients having day surgery. Researchers took two swabs from the surgi…

This study measured how often sleep disturbances occur in people with bullous pemphigoid, a blistering skin condition that mostly affects older adults. Researchers compared 122 patients to healthy volunteers using a simple insomnia questionnaire. The goal was to understand if sle…

This study looked at whether a short mental training session could help anesthesia residents feel less stressed before performing an epidural on a pregnant patient. Thirty-two residents were split into two groups: one got mental preparation, the other did not. Researchers measure…

This study looked at sleep quality in 42 adult ICU patients using simple questionnaires. Researchers wanted to see how sleep changes over time and if a special recovery unit helps. The goal is to better understand sleep problems in the ICU, which can affect healing.

This study used a special ultrasound technique called elastography to measure heart muscle stiffness during planned aortic valve replacement surgery. Researchers compared stiffness in patients with aortic stenosis to those having bypass surgery. The goal was to see if aortic sten…

This study looked back at 52 Crohn's disease patients with anal fistulas who were treated with biotherapy (infliximab, adalimumab, ustekinumab, or vedolizumab). Researchers compared their MRI scans at the start of treatment and during follow-up to see how the fistulas changed ove…