University Hospital, Rouen

This study tested whether pacing three spots in the heart instead of the usual two could improve cardiac resynchronization therapy (CRT) for people with heart failure. About 30% of patients don't respond well to standard CRT. The trial planned to enroll 36 adults with severe hear…

This study looked at whether hydroxychloroquine (Plaquenil) could improve artery function in people with antiphospholipid syndrome (APS), a condition that raises the risk of blood clots. Researchers planned to give either hydroxychloroquine or a placebo to 25 participants and mea…

This study looked at whether switching kidney transplant patients from tacrolimus to sirolimus (both with mycophenolate mofetil) could reduce long-term complications like kidney damage, diabetes, and cancer. It involved 65 stable transplant recipients between 12 and 36 months aft…

This study tested whether giving the drug caplacizumab based on regular blood tests (ADAMTS13 activity) could improve outcomes for adults with acquired thrombotic thrombocytopenic purpura (aTTP), a rare condition causing dangerous blood clots. The trial enrolled 58 adults and mon…

This study looked at whether a blood test that detects circulating tumor cells (CTCs) could diagnose pancreatic cancer. Researchers planned to compare the blood test results with standard tissue biopsies in 101 people with pancreatic tumors. The trial was terminated early, so the…

This study tested whether a special CT scan can accurately assess heart muscle damage in people who had a heart attack more than 24 hours earlier. The goal was to see if this CT could replace the need for both an MRI and an invasive angiogram. The study enrolled 31 adults and com…

This study tested whether a one-minute sit-to-stand test could help emergency doctors decide if COVID-19 patients need hospital care. The test measures oxygen levels and breathing effort during repeated standing from a chair. The trial aimed to reduce unnecessary hospital stays b…

This study looked at whether moderate physical activity three times a week could reduce chronic fatigue in people with inflammatory bowel disease (IBD). Fatigue affects about 40% of IBD patients and can lower quality of life. The trial planned to compare a group that added extra …

This study tested whether giving continuous local anesthetic (ropivacaine) near the incision after liver surgery could improve diaphragm function and reduce lung complications. It planned to include 88 adults, but was terminated early after enrolling only 31. The main goal was to…

This study tested whether adding a smartphone app to the usual pre-surgery talk could lower anxiety in children aged 4 to 10. About 182 kids scheduled for surgery were to be enrolled. The trial was stopped early, so results are limited.

This study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clear…

This study tested whether a gas sedative (isoflurane) could help patients with septic shock wake up and get off a breathing machine faster than standard IV sedation (midazolam). The goal was to reduce complications from long-term sedation and ventilation. Only one patient was enr…

This study looked at whether a gentle, adapted physical activity program could help women with anorexia nervosa during refeeding. Researchers measured changes in a metabolic pathway linked to mood and energy. Only 9 people took part, and the study was stopped early, so the findin…

This study aimed to find the best dose of the antibiotic ceftriaxone for adults with urinary tract infections in the emergency department. Researchers measured how the drug behaves in the body to ensure it stays at effective levels long enough to kill bacteria. The study was stop…

This study aimed to see if immune cells in the blood match those inside lung tumors. Researchers hoped to find a simple blood test that could help doctors decide which patients might respond to immunotherapy. The study planned to enroll 22 people with early-stage lung cancer who …

This study aimed to find inherited gene changes in people diagnosed with cancer at a young age, including breast, ovarian, colorectal, and pediatric cancers. Researchers used a special test to look at 200 genes linked to cancer in 289 participants. The goal was to better understa…

This study tested whether a website could help parents better understand and follow painkiller prescriptions after their child's outpatient surgery. The researchers planned to enroll 200 children aged 2 to 12 and their families at Rouen University Hospital. The study was terminat…

This study looked at whether pain-relief drugs given during labor (ropivacaine and sufentanil) can pass into the mother's blood and cause abnormal heart rhythms in the baby. It involved 40 first-time mothers with a single baby in head-first position. The goal was to measure drug …

This study looks at whether a short, early language therapy program can improve reading skills in children born very preterm (before 32 weeks). Researchers will follow 108 children up to age 8, measuring reading speed and language understanding. The goal is to see if early help c…

This study aimed to check how accurate several COVID-19 antibody tests are. Researchers used blood samples from 101 adults, including some taken before the pandemic and some from people with other infections. The goal was to see which tests best detect past COVID-19 infection.

This study aimed to see if a tiny camera on a thin tube (bronchoscopy) could help doctors diagnose diffuse lung diseases without needing a surgical lung biopsy. The camera takes live microscopic images of the air sacs. The study was stopped early, but it involved 38 adults with c…

This study used a special microscope on the tip of a thin tube (bronchoscope) to look at the smallest blood vessels in the lungs of people with scleroderma or emphysema. The goal was to see how these vessels change in each disease. Only 9 patients were enrolled before the study w…

This study aimed to see if the heart-lung machine used during heart surgery changes blood flow in the gut. Researchers checked blood flow under the tongue as a way to measure gut health. The study was stopped early and included only 21 adults having aortic valve replacement. It w…

This study aimed to see if the amount of sunitinib in the blood affects side effects and how well the drug works in people with metastatic kidney cancer. Researchers planned to collect extra blood samples during routine visits from patients starting sunitinib as their first treat…

This study aimed to see if measuring the glycocalyx—a thin, protective layer inside blood vessels—before heart surgery could predict serious problems like shock, kidney failure, or death. Researchers planned to include 130 adults having heart surgery with a heart-lung machine. Th…

This study aimed to find brain and movement markers in people with a type of depression that doesn't respond to standard antidepressants, called anhedonic depression. Researchers measured brain waves (P300), walking speed, and hand movements in 36 participants. The goal was to id…

This study tested whether giving patients detailed instructions for showering before scheduled surgery could improve skin cleanliness when they arrive at the operating room. The goal was to reduce the risk of surgical site infections. Only 22 adults participated before the study …