University Hospital, Rouen

This study tested whether using three pacing leads instead of the usual two could help more people with heart failure. About 30% of patients don't improve with standard cardiac resynchronization therapy (CRT). The trial aimed to see if triple-site pacing could shrink the heart's …

This study tested a personalized approach to treating acquired thrombotic thrombocytopenic purpura (aTTP), a rare and serious blood clotting disorder. Researchers gave 58 adults a drug called caplacizumab, with the dose adjusted based on regular monitoring of a key blood enzyme (…

This study looked at whether adding hydroxychloroquine to standard care could improve artery function in people with antiphospholipid syndrome, a condition that raises the risk of blood clots. The trial planned to enroll 25 adults, but was terminated early. Participants were rand…

This study looked at kidney transplant patients to compare two drugs—sirolimus and tacrolimus—both given with another drug called mycophenolate mofetil. The goal was to see which combination caused fewer long-term problems like kidney damage, diabetes, or cancer. The study was st…

This study aimed to see if a blood test could detect pancreatic cancer by finding circulating tumor cells (CTCs) or tumor DNA, potentially avoiding the need for invasive biopsies. Researchers planned to compare the blood test results with standard tissue sampling in 101 adults wi…

This study looked at whether a special CT scan (dual-energy cardiac CT) can check heart muscle damage as well as an MRI in people who had a heart attack more than 24 hours earlier. The goal was to see if the CT scan could give doctors enough information to decide on treatment, av…

This study looked at whether a continuous injection of a numbing medicine (ropivacaine) near the surgical cut could improve diaphragm function and reduce lung complications after upper abdominal surgery. The study planned to include 88 people having liver surgery, but was stopped…

This study tested whether a smartphone app, used alongside a regular doctor visit, could lower anxiety in children aged 4 to 10 before planned surgery. About 182 children were expected to join. The study was stopped early, so results are limited.

This study looked at whether using an inhaled sedative (isoflurane) helps patients with septic shock wake up and come off a breathing machine faster compared to standard IV sedation (midazolam). The trial was planned for adults in the ICU who needed sedation for 3 to 28 days. How…

This study compared two types of non-invasive breathing machines (AVAPS-AE vs. S/T mode) in 14 adults with acute respiratory failure, obesity, and high carbon dioxide levels. The goal was to see which machine more quickly corrected the carbon dioxide levels and reduced breathing …

This study looked at 289 people with early-onset breast, ovarian, colorectal, or pediatric cancers, plus those with multiple tumors. Researchers used a special test to check 200 genes for inherited mutations that standard tests might miss. The goal was to better understand why th…

This study tested a website designed to help parents and children better understand painkiller prescriptions after outpatient surgery. The goal was to improve how families manage pain at home and ensure they follow the doctor's instructions. The study included 200 children aged 2…

This study aimed to see if measuring a thin layer inside blood vessels (glycocalyx) before heart surgery could predict serious problems like shock, kidney failure, or death. It included 130 adults having heart surgery with a heart-lung machine. The study was stopped early, so res…

This study aimed to see how accurate different COVID-19 antibody tests are. Researchers used blood samples from 101 adults, including some taken before the pandemic and some from people with other infections. The goal was to find which tests best detect past COVID-19 infection.

This study aimed to understand how the amount of sunitinib in the blood relates to severe side effects and treatment success in people with metastatic kidney cancer. Researchers planned to collect extra blood samples during routine tests from 6 patients starting sunitinib therapy…

This study looks at children born very preterm (before 32 weeks) who received a short, structured language therapy when they were 3 to 4 years old. Researchers want to see if that early help improves their reading speed and language skills by age 8. The study involves 108 childre…

This study looked at whether a gentle exercise program could help women with anorexia nervosa during refeeding. It focused on how exercise affects certain chemicals in the body linked to mood and metabolism. The study was stopped early and included only 9 participants, so results…

This study aimed to see if the heart-lung machine used during heart surgery changes blood flow in the gut. It included 21 adults having aortic valve replacement. Researchers checked blood flow under the tongue as a way to measure gut blood flow. The study was stopped early, so re…

This study aimed to find brain wave and movement patterns that could identify a specific type of depression where people lose interest in activities (anhedonia) and don't respond to standard antidepressants. Researchers compared 36 people with this condition to healthy volunteers…

This study tested a mini-invasive camera that looks at tiny air sacs in the lungs during a routine bronchoscopy. The goal was to see if this imaging method could help diagnose diffuse lung diseases without needing a surgical biopsy. The study was stopped early, but it involved 38…

This study aimed to describe the tiny blood vessels in the lungs of people with scleroderma or emphysema using a special microscope during a bronchoscopy. Researchers wanted to see how these vessels are damaged in each disease to better understand what causes the damage. Only 9 p…

This study aimed to see if teaching patients a specific way to shower before surgery leads to cleaner skin when they arrive at the operating room. It included 22 adults scheduled for various surgeries. The study was terminated early, so results are limited.

This study looked at whether a simple sit-to-stand test could help emergency doctors decide which COVID-19 patients need to stay in the hospital. The test measures how many times a person can stand up from a chair in 30 seconds. The goal was to see if using this test, along with …