University Hospital, Rouen

This study tests the safety of a rotigotine skin patch in 120 adults aged 18–60 with autosomal dominant polycystic kidney disease (ADPKD), a genetic condition causing kidney cysts and eventual kidney failure. Participants will wear the patch daily for 24 months. The goal is to se…

This study tests baricitinib, a drug used for arthritis, in 33 adults with a type of eye inflammation (non-infectious uveitis) that hasn't improved with other treatments. Participants will stop their current medications and take baricitinib for 6 months to see if it can control t…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study looks at kidney transplant patients who take drugs to prevent organ rejection. Some take standard anticalcineurin drugs, which can harm blood vessels and raise heart risks. Others switch to a newer drug called belatacept. The goal is to see if belatacept improves blood…

This study looks at kidney transplant recipients who develop antibodies against their new kidney without any signs of kidney damage. Researchers want to see if switching to a drug called belatacept, along with standard treatments, can prevent further rejection better than staying…

This study tests whether a common antibiotic for women's UTIs (fosfomycin-trometamol) works well for men with urinary tract infections. Current treatments can cause rare but serious side effects. The trial will enroll 138 men in primary care and track treatment success for 14 day…

This study tests a technique called ischemic preconditioning to reduce kidney injury after open surgery for a type of abdominal aortic aneurysm. About 206 adults aged 18-85 will be randomly assigned to receive either the preconditioning or standard care. The goal is to see if bri…

This study compares two antibiotic approaches after pancreatic surgery in patients who had a bile duct stent placed before surgery. The goal is to see if a 5-day course of broad-spectrum antibiotics works better than a single preventive dose at reducing serious infections inside …

This phase 3 trial tests whether monitoring tumor DNA in the blood (ctDNA) can help doctors decide when to reduce or change chemotherapy for people with advanced colorectal cancer that cannot be removed by surgery. About 408 participants will be randomly assigned to either standa…

This study tests a brain implant called deep brain stimulation (DBS) to help control severe aggression in people with autism or schizophrenia who have not responded to any other treatment. Six adults who have been in locked psychiatric units for months will receive the implant. T…

This study looks at a new way to detect acute kidney injury after heart surgery using an ultrasound technique called VEXUS. About 250 adults having valve or bypass surgery will be checked. The goal is to see if this test can spot kidney problems earlier than current methods, whic…

This study tests a computer program that scans electronic medical records to help general practitioners identify asthma in children aged 2 to 5. The goal is to catch the disease earlier, which could reduce serious breathing problems and deaths. About 300 children from four clinic…

This study tests a drug called iloprost to see if it can reduce pain and the need for strong painkillers in adults with sickle cell disease who are hospitalized for a painful crisis. Iloprost helps open blood vessels and reduce inflammation. About 144 participants will receive ei…

This study tests whether doing balance exercises with eyes closed soon after total knee replacement helps patients recover better. About 66 adults aged 60-85 with knee osteoarthritis will be split into two groups: one doing standard rehab plus eyes-closed balance training, the ot…

This study tests whether a handheld device called AccuVein helps nurses insert an IV on the first try in patients with hard-to-find veins. About 100 adults who are difficult to infuse will be randomly assigned to have their IV placed with or without the device. The main goal is t…

This study aims to see if a blood sample taken from the vein that drains a brain arteriovenous malformation (AVM) can detect the genetic mutations driving the condition. Researchers will compare these results with blood from a regular arm vein. The goal is to find a less invasive…

This study looks at how immune checkpoint inhibitors, a type of cancer immunotherapy, may affect blood vessels. Researchers will measure artery stiffness in 200 cancer patients before and after starting treatment to see if these drugs increase the risk of vascular problems. The g…

This study will measure how a specially prepared liquid form of the blood pressure drug nicardipine works in 30 children aged 1 to 15 who are being treated for cancer. The goal is to learn how the medicine moves through their bodies so doctors can give the right dose. This resear…

This study tests whether a brief question from a nurse can reduce the number of unnecessary IV catheters placed in emergency department patients. About 1,680 adults who need a blood draw and IV line will take part. The goal is to see if this simple check lowers patient pain, save…

This study looks at how the antibiotic piperacillin-tazobactam is cleared from the body by continuous kidney replacement therapy in intensive care patients with severe infections. Researchers will measure drug levels in 24 adults to help doctors give the right dose—avoiding under…

This study aims to find out if women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain scores and other gynecological issues between 156 women with EDS and a control group using online questionnair…

This study looks at how the non-opioid painkiller nefopam is processed by the body in adults hospitalized with acute rheumatic pain. Researchers will measure drug levels in the blood to understand its breakdown and availability. The goal is to gather more information on how to be…

This study will test whether a blood test done before lung surgery can predict serious breathing problems afterward. About 100 adults having keyhole lung surgery will provide blood samples for immune system analysis. The goal is to develop a tool that helps doctors identify high-…

This study looks at 350 people having lung surgery for cancer. After surgery, the collapsed lung needs to be re-inflated. Doctors want to see if using a machine that controls air pressure and volume is better than the usual manual method. The goal is to find which technique cause…

This study looks at whether a personalized health plan can help frail people aged 70 and older maintain a better quality of life. Researchers will compare two groups of 120 participants over two years. The goal is to see if tailored support helps seniors stay active and independe…

This study looks at a new phone service in Le Havre that helps people decide where to go for medical care. When you call, a trained assistant quickly figures out if you need emergency help or can see a regular doctor. The goal is to see if this service reduces unnecessary trips t…

This study looks at whether monitoring the lung's air capacity during surgery that uses only one lung can help prevent lung collapse and related problems. About 44 adults having lung surgery will be randomly assigned to either have or not have special breathing maneuvers based on…

This study follows 60 adults with pulmonary hypertension to see how sleep-related breathing issues and heart rate patterns evolve over two years. Participants will have overnight sleep tests at the start, 12 months, and 24 months. The goal is to find better ways to predict and ma…

This study looks at why some people with irritable bowel syndrome (IBS) feel pain after eating fructose (a sugar found in fruit). Researchers think gut bacteria and a hormone called cholecystokinin may be involved. 60 adults with IBS will provide stool samples, food diaries, and …