University Hospital, Rouen

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study compares two antibiotic strategies in 326 adults undergoing pancreatic surgery who had a bile duct stent placed before surgery. One group gets antibiotics only during surgery, the other gets them for 5 days after. The goal is to see if the longer course reduces surgica…

This study tests a brain implant called deep brain stimulation (DBS) to help six adults with severe aggression that hasn't improved with medication or other therapies. Participants have either autism or schizophrenia and live in locked psychiatric units. The implant targets a bra…

This study tests whether switching to belatacept (a drug) plus standard care can better treat early antibody-mediated rejection in kidney transplant patients compared to continuing standard care alone. About 290 adults with new donor-specific antibodies but no kidney function dec…

This phase 3 trial tests whether a blood test that measures tumor DNA (ctDNA) can help doctors decide when to reduce or switch chemotherapy in people with metastatic colorectal cancer. About 408 participants will be randomly assigned to either standard treatment or a strategy whe…

This study tests whether a short, controlled clamping of the aorta before aneurysm surgery can prevent acute kidney injury. About 206 patients will be randomly assigned to receive this preconditioning or standard care. The goal is to see if this simple procedure lowers the risk o…

This study tests baricitinib, a drug used for arthritis, in 33 adults with a type of eye inflammation (uveitis) that hasn't improved with other treatments. The goal is to see if it can stop the inflammation completely after 6 months. Participants must stop their current medicatio…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study aims to see if a blood test, taken before lung cancer surgery, can predict which patients will develop serious lung complications afterward. Researchers will analyze immune cells and proteins in the blood of 100 adults undergoing lung surgery. If the test works, it cou…

This study tests a computer program that scans electronic medical records to help family doctors find asthma in children aged 2 to 5. The goal is to catch the disease earlier, which could reduce serious breathing problems and deaths. About 300 children from four clinics in France…

This study tests if iloprost, a drug that widens blood vessels and reduces inflammation, can help adults with sickle cell disease during painful vaso-occlusive crises. About 144 participants hospitalized for a crisis will receive either iloprost or a placebo, plus standard care. …

This study tests whether the AccuVein device, which uses light to map veins, helps nurses insert IV lines on the first try in patients with difficult veins. One hundred adults who are hard to infuse will be randomly assigned to get an IV with or without the device. The main goal …

This study tests whether doing balance exercises with your eyes closed soon after knee replacement surgery improves recovery. About 66 people aged 60-85 who had a knee replaced due to arthritis will be split into two groups: one does standard rehab, the other adds special balance…

This study will follow 200 cancer patients starting immune checkpoint inhibitors (ICIs) to see if these drugs stiffen the arteries. Researchers will measure pulse wave velocity before treatment, after 6-8 weeks, and at one year. The goal is to better understand vascular side effe…

This study tests whether using a special ventilator monitor to track lung volume during one-lung surgery, combined with lung-opening maneuvers, can prevent lung collapse after surgery. 44 adults having lung surgery will be randomly assigned to either standard care or the monitori…

This study looks at whether a personalized health plan (PHP) can improve quality of life for frail people aged 70 and older. Researchers will give participants various quality-of-life tests and share the results with their doctor and the patient. The study will follow 120 partici…

This study looks at two different methods doctors use to re-inflate a lung after it has been collapsed during surgery. About 350 people having lung surgery will take part. The goal is to see which method leads to fewer lung problems like pneumonia or collapsed air sacs in the wee…

This study looks at adults with severe constipation and an enlarged rectum (idiopathic megarectum) to see if the problem started in childhood. Researchers will compare 120 participants—some with the condition and some without—by asking about their early-life digestive health and …

This study tests whether a nurse asking a doctor why they are ordering an IV line can reduce unnecessary placements. About 1,680 emergency department patients will take part. The goal is to lower patient pain, infection risk, and costs by avoiding IVs that aren't needed.

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study will examine how the painkiller nefopam works in 24 adults hospitalized with acute rheumatic pain. Researchers will measure how the drug is processed in the body, including its peak levels and how long it stays active. The goal is to better understand the drug's effect…

This study looks at how a specially prepared liquid blood pressure medicine (nicardipine) works in 30 children aged 1-15 who have both cancer and high blood pressure. Researchers will take small blood samples to measure how the medicine moves through the body. The goal is to find…

This study looks at why some people with irritable bowel syndrome (IBS) feel more belly pain after eating fructose (a sugar found in fruit). Researchers will check the gut bacteria and other body signals in 60 IBS patients. No new treatment is tested — the goal is to better under…

This study will test a new phone-based healthcare access service (SAS) in Le Havre, France, designed to direct non-emergency callers to primary care instead of the emergency room. Researchers will compare ER visit rates between callers using the new system and those using the sta…

This study looks at how the antibiotics piperacillin and tazobactam are cleared from the body by continuous kidney replacement therapy in intensive care patients with severe infections. Researchers will measure drug levels in 24 adults to better understand dosing needs. The goal …

This study will analyze blood samples from the drainage vein of brain arteriovenous malformations (AVMs) in 16 adults undergoing embolization. The goal is to identify genetic mutations that may drive these abnormal vessels. Understanding these mutations could pave the way for fut…