University Hospital, Rouen

This study aims to see if a newer anti-rejection drug called belatacept is better for heart and blood vessel health than standard drugs in kidney transplant patients. It will involve 44 people who have had a kidney transplant for over a year. Researchers will measure blood vessel…

This study aims to find the best way to prevent infections after a major pancreas surgery (pancreaticoduodenectomy) in patients who had a bile duct stent placed beforehand. Researchers will compare giving a strong antibiotic for just the day of surgery versus giving it for five d…

This study is testing whether a medication called domperidone, which helps the stomach empty faster, can improve blood sugar control in adults with Type 1 diabetes. Researchers want to see if treating a common but often unnoticed slow stomach emptying can help patients spend more…

This study tests whether a new technique called 'ischemic preconditioning' can protect kidneys during complex aortic aneurysm surgery. The technique involves briefly restricting and then restoring blood flow to the kidneys before the main surgery begins. Researchers will compare …

This study aims to find the best way to re-inflate a patient's lung after lung cancer surgery to reduce breathing problems. It will compare a standard manual method to a newer, monitored method using the anesthesia machine. The goal is to see which technique leads to fewer compli…

This study is testing whether the drug baricitinib can control a specific type of serious, persistent eye inflammation called uveitis in patients for whom other powerful biologic treatments have not worked. It will involve 33 adults who have this condition and need to stop their …

This study is testing whether an antibiotic called fosfomycin can effectively treat urinary tract infections in men while avoiding the serious side effects of current standard antibiotics. The trial will enroll 138 adult men with non-febrile UTIs in primary care settings across F…

This study is testing whether a low-dose dopamine patch (rotigotine) is safe and tolerable for people with inherited polycystic kidney disease (ADPKD) over two years. It will involve 120 adults with ADPKD to see if the patch can help slow the disease's progression and protect kid…

This study is testing if a blood test that measures tumor DNA can help doctors make better treatment decisions for people with advanced colon cancer that has spread. About 408 participants will be randomly assigned to either have their treatment adjusted based on the blood test r…

This study is testing whether switching kidney transplant patients from standard anti-rejection drugs to a newer drug called belatacept can better control early, silent rejection. Researchers will enroll 290 adult kidney transplant recipients who develop certain antibodies but sh…

This study is testing if a new monitoring method during chest surgery can help prevent lung collapse, a common and serious complication. Researchers will use a special ventilator to watch lung volume in real-time and perform personalized breathing exercises to keep the lungs open…

This study is testing whether creating a personalized health plan for frail older adults, managed by a team of healthcare professionals, can improve their quality of life. It will involve 120 participants aged 70 and over who are identified as frail but still living independently…

This study aims to create a test that predicts which patients are likely to develop serious breathing problems after lung cancer surgery. Researchers will analyze blood samples from 100 patients before their operation, looking for signs in the immune system that signal high risk.…

This study is testing whether a special light-up device called AccuVein helps nurses insert an IV line on the first try in patients who are known to have difficult veins. It will compare the device to the standard method of finding a vein by sight and touch. The goal is to see if…

This study is testing a new ultrasound method called the VEXUS score to detect kidney injury in patients after heart surgery. Researchers will enroll 250 adults having heart surgery to see if this scan can spot kidney problems earlier and more accurately than current methods. The…

This study aims to test a new computer algorithm designed to help family doctors identify asthma in children under 6 years old earlier. It will analyze information already in children's electronic health records to flag potential cases. The goal is to help doctors make a diagnosi…

This study aims to understand how the body absorbs and processes nefopam tablets, a non-opioid pain medication, in patients hospitalized with sudden, severe rheumatic pain. Researchers will measure how quickly the drug reaches the bloodstream, how long it stays in the body, and h…

This study is testing whether a drug called iloprost can help adults with sickle cell disease during painful vaso-occlusive crises. Researchers will give 144 hospitalized patients either iloprost or a placebo through an IV to see if it reduces their pain and how much opioid pain …

This study is testing a new rehabilitation method to help people recover balance and mobility after knee replacement surgery. It will compare standard rehab exercises to exercises done with eyes closed, focusing on the body's internal sense of position. The goal is to see if this…

This study is testing whether a surgical procedure called deep brain stimulation can help control severe, dangerous aggression in patients with schizophrenia or autism. The six participants have not responded to any other treatments and are confined to secure psychiatric units. D…

This study aims to see if starting sildenafil (the drug in Viagra) early after surgery and radiation for rectal cancer can prevent long-term erectile dysfunction. It will involve 188 men who had normal sexual function before their cancer treatment. Participants will be randomly a…

This study aims to better understand how nighttime breathing problems and related changes in heart rate patterns affect people with pulmonary hypertension, a serious condition of high blood pressure in the lungs. Researchers will monitor 60 patients over two years using sleep stu…

This study aims to evaluate a new phone-based healthcare access service in Le Havre, France. It will compare the new system, which quickly directs callers to appropriate non-emergency care, to the old standard system. Researchers want to see if the new approach reduces unnecessar…

This study aims to understand how gut bacteria might connect difficulty digesting fructose (a sugar in fruit) to increased gut pain in people with Irritable Bowel Syndrome (IBS). Researchers will compare 60 IBS patients, grouped by whether they have fructose malabsorption and/or …

This study aims to better understand how a liquid blood pressure medicine (nicardipine) works in children with cancer who develop high blood pressure. Researchers will measure how the child's body processes the medicine to find the safest and most effective dose. The goal is to i…

This study aims to understand if women with Ehlers-Danlos syndrome (EDS) experience more severe period pain compared to women without the condition. Researchers will survey 156 women, asking them to rate their pain and report other gynecological issues. The goal is to gather bett…

This study aims to see if a simple blood test, taken from a vein near a brain blood vessel malformation during planned surgery, can detect specific genetic changes. Researchers hope finding these genetic markers will help develop future non-invasive drug treatments. The study wil…

This study aims to understand how a common antibiotic combination is removed by kidney dialysis machines in critically ill patients with severe infections. Researchers will measure drug levels in 24 intensive care patients who are on dialysis and receiving this antibiotic. The go…

This study aims to understand the gynecological and sexual side effects women experience after treatment for rectal cancer. Researchers will survey 15 women who completed treatment between 2020 and 2025 and are now in remission. The goal is to better identify and describe these o…