University Hospital, Rouen

This study is testing whether giving chemotherapy before tumor removal surgery helps more patients with blocked colon cancer complete their full recommended treatment. Patients who have already had a temporary colostomy to relieve the blockage will be randomly assigned to receive…

This study is testing a more personalized approach to managing pemphigus, a serious autoimmune disease that causes painful skin blisters. Researchers want to see if adjusting the timing and dose of a standard drug (rituximab) based on a patient's specific antibody levels works be…

This study is testing the safety of a new treatment for painful thumb arthritis (rhizarthrosis). Doctors will take a small amount of a patient's own fat, process it to get regenerative cells, and inject it into the thumb joint. The goal is to see if this one-time injection is saf…

This study is testing whether starting a long-term gout medication called febuxostat immediately after a painful flare-up works as well as the current standard of waiting 6 weeks. It involves 128 adults in France who are having a gout attack. The goal is to see if early treatment…

This study is testing whether a serious autoimmune blood disorder called iTTP can be treated without the standard, invasive plasma exchange procedure. Researchers want to see if giving patients a lower dose of plasma directly into their veins, along with two other medications, wo…

This study is testing a new, personalized approach to chemotherapy for people with pancreatic cancer who have had surgery. After initial chemotherapy and surgery, doctors will look at how much cancer is left and assign patients to one of two different follow-up chemotherapy plans…

This study is testing whether the medication apremilast can completely clear painful mouth ulcers in people with severe, hard-to-treat cases. It's a Phase 3 trial comparing apremilast to a placebo (dummy pill) over 12 weeks in 134 adults whose ulcers haven't responded to the usua…

This study aims to find the best surgical method for treating a severe abdominal infection caused by a burst diverticulum in the colon. It will compare two approaches: one that reconnects the bowel immediately and another that adds a temporary stoma bag to protect the connection.…

This study is testing if adding hip muscle exercises to standard pelvic floor training helps women with stress urinary incontinence better control bladder leaks. Researchers will compare two groups of 78 women: one doing standard exercises and another adding hip exercises. The go…

This study is testing if following a specific low-calorie, high-protein diet for about a month before weight-loss (bariatric) surgery makes the operation easier and safer. The diet aims to shrink the liver and reduce belly fat, which can help the surgeon during the procedure. Res…

This study is testing whether a stronger form of home oxygen therapy can help people with severe COPD stay healthier and avoid future hospital visits. It will compare high-flow oxygen to standard oxygen therapy in 406 patients who were recently hospitalized for a COPD flare-up. T…

This study is testing if adding a new type of drug (an endothelin receptor blocker) can improve blood vessel health and help control blood pressure in people whose high blood pressure remains high despite taking three medications. Researchers will measure how well blood vessels r…

This study compares two different pacemaker settings in patients who have had a procedure to control rapid atrial fibrillation. Researchers want to see which setting helps patients exercise better by measuring how much oxygen their bodies can use during physical activity. The stu…

This study is testing which of two powerful drugs is better at controlling severe mucous membrane pemphigoid (MMP), a rare autoimmune disease that causes painful blisters and scarring on moist body surfaces like the eyes and throat. About 130 adults with severe forms of the disea…

This study is testing if taking a daily low-dose aspirin pill can prevent colon cancer from returning after surgery. It will involve 264 patients whose cancer has a specific genetic change (PI3K mutation). Participants will be randomly assigned to take either aspirin or a placebo…

This study is testing whether taking glutamine, a common amino acid, as a powder for 8 weeks can help improve blood sugar control and ease irritable bowel syndrome (IBS) symptoms in people with obesity. It will involve 110 participants who will be randomly assigned to receive eit…

This study is testing a new, more detailed diagnostic tool called high-resolution manometry to better understand severe constipation that doesn't respond to standard laxatives. Researchers will compare measurements from patients with this severe condition to those from healthy vo…

This study aims to screen 100,000 newborns in France for two rare genetic disorders (MPS I and Pompe disease) using a simple blood spot test. The goal is to understand how common these diseases are and to detect them early, when treatment may be most effective. Participation is v…

This study is testing whether a new blood test can predict if liver cancer will come back after surgery. Researchers will measure tiny pieces of tumor DNA in the blood of 150 patients before and after their treatment. The goal is to see if this 'liquid biopsy' can provide an earl…

This study is testing a new, more detailed genetic analysis method to better identify people who carry the gene for Spinal Muscular Atrophy (SMA). Current carrier tests can miss some people who have a specific, hard-to-detect genetic pattern. The goal is to improve screening so c…

This study is testing a new, simpler ultrasound method to measure how well the heart is pumping blood in critically ill patients. Researchers want to see if a quick scan from under the ribs gives results as good as the standard, more difficult method. The goal is to make this imp…

This study is testing a simple screening method for hepatitis B, hepatitis C, and AIDS. Researchers will use a dried blood spot from a finger prick to test 500 current or former intravenous or nasal drug users. The goal is to see if this easier method can effectively find these i…

This study aims to see if a simple one-minute test of standing up and sitting down in a chair can help doctors better predict which patients with non-severe lung blood clots (pulmonary embolism) are at higher risk for complications. Researchers will enroll 180 hospitalized patien…

This study aims to see if a simple swallowing test performed by a physiotherapist is as good as a more complex scope exam for finding vocal cord paralysis after major lung cancer surgery. Vocal cord paralysis is a common complication that can lead to serious swallowing problems a…

This study is testing a new, personalized approach to prevent CMV infections in kidney transplant patients. It compares a strategy guided by the patient's own immune response to the standard practice of giving preventive antiviral drugs to everyone. The goal is to see if the pers…

This study is testing if a personalized medication plan can help hospitalized patients with sudden, severe musculoskeletal pain use strong opioid painkillers for a shorter time. The goal is to see if better patient information and support during their hospital stay reduces the to…

This study is testing if performing a pelvic exam while a woman lies on her side is a good alternative to the traditional position. The goal is to see if this side-lying position is more comfortable and less stressful, which could help women feel better about getting regular chec…

This study is testing whether using a special video game system at home can help people with Parkinson's disease who have trouble walking and keeping their balance. 80 participants will be split into two groups: one will use the video game therapy along with their usual care for …

This study is testing if a standard breathing and exercise rehabilitation program can improve sleep quality for people with stable COPD. Researchers will compare sleep measurements from 90 participants who either complete the rehab program or receive their usual care. The main go…

This study is testing whether simple, non-drug techniques like aromatherapy (using scents) and music therapy can help reduce stress, anxiety, and pain for patients getting a cerebral arteriography, a type of brain scan. Researchers will measure patients' stress levels, blood pres…

This study is testing whether taking glutamine, a natural amino acid, can help reduce symptoms in adults with a specific type of irritable bowel syndrome (IBS-D). Researchers want to see if glutamine can improve gut health and ease symptoms like abdominal pain and diarrhea. The t…

This study is testing whether a dietary supplement called DIELEN Protect can help reduce the symptoms of Irritable Bowel Syndrome (IBS). One hundred adults with moderate to severe IBS will take either the supplement or a placebo for eight weeks. Researchers will measure changes i…

This study is testing if adding endurance training to standard physical therapy helps people recover better after lung cancer surgery. It will involve 184 patients who have had a minimally invasive lung resection. The goal is to see if this more intensive rehab improves patients'…

This study is testing whether a device that sends mild electrical pulses to the spinal cord is safe for Parkinson's patients who have a painful, forward-bending posture called camptocormia. The goal is to see if this stimulation can help reduce pain and improve posture when other…

This study aims to find out if using a special time-lapse camera system to watch embryo development helps doctors choose the best embryo for transfer during IVF, compared to the standard method of looking at still pictures. It will involve 520 couples undergoing IVF for male infe…

This study compares two breathing support methods—high-flow oxygen therapy and non-invasive ventilation—to see which one better helps heart function in people with chronic heart failure. Researchers will measure how each method affects heart pressures and patient comfort in 30 pa…

This study aims to find out if the standard 1-gram daily dose of the antibiotic ceftriaxone is effective for all adults hospitalized with a urinary tract infection (UTI). Researchers will measure drug levels in the blood of 300 patients to see if the dose is strong enough to figh…

This study aims to better understand how often dangerous blood clots return in people with antiphospholipid syndrome, a rare autoimmune condition. Researchers will follow 200 patients over time to track their health outcomes and identify factors that increase recurrence risk. The…

This study aims to better understand common, long-term digestive problems like irritable bowel syndrome (IBS) and chronic constipation. Researchers will collect health data and samples (like blood and stool) from 2,000 adult patients during their regular doctor visits. The goal i…

This study aims to understand how the community of bacteria in the airways might be linked to severe asthma in infants. Researchers will collect and analyze fluid samples from the nose, throat, and lungs of 100 babies under 2 years old who have severe asthma. The goal is to gathe…

This study aims to understand how botulinum toxin (Botox) injections in the rectum help people with fecal incontinence (bowel leakage). Researchers will measure bowel muscle activity in 21 adults before and after the injections to see how the treatment works. The goal is to learn…

This small, early-stage study aims to understand if a drug called aprepitant can lower levels of a hormone called aldosterone in people with severe sleep apnea and high blood pressure. Researchers want to see if blocking a brain chemical called substance P affects this hormone, w…

This study is trying to find out if measuring a protein called PLGF in the umbilical cord or placenta can serve as an early warning sign for brain damage in babies exposed to alcohol during pregnancy. Researchers will compare PLGF levels in 60 mother-baby pairs where the mother d…

This study aims to understand how a specific hands-on therapy technique might change how healthy people feel pain. Researchers will test 54 volunteers without back or leg pain to see if the technique makes them less sensitive to pressure. The goal is to learn more about how this …

This study aims to better understand Irritable Bowel Syndrome (IBS) by closely following 600 people with the condition over several years. Researchers will collect detailed information about participants' symptoms, lifestyle, diet, and gut bacteria to learn what factors influence…

This study aims to understand if gut bacteria from people with eating disorders can cause weight changes or digestive issues in mice. Researchers will transplant stool samples from patients and healthy volunteers into mice and monitor their weight, eating habits, and digestion. T…

This study aims to understand if patients who develop chronic, widespread itch while receiving certain cancer immunotherapies have specific antibodies in their blood. Researchers will check blood samples from 100 patients to see if these antibodies are present. The goal is to lea…

This study aims to understand if a specific property of the carotid artery, called 'wall viscosity,' is linked to vascular dementia and Alzheimer's disease. Researchers will measure this artery stiffness in 140 participants over age 70 who have either type of dementia or memory c…