University Hospital, Rouen

This study looks at two ways to treat severe peritonitis caused by a burst diverticulitis pocket. Both involve removing the diseased part of the colon and reconnecting the bowel. One group also gets a temporary stoma (a bag on the belly) to protect the new connection, while the o…

This study looks at whether giving gout medication (febuxostat) right after an attack is better than waiting 6 weeks, which is the current standard. About 128 people with gout will be split into two groups to compare how many days they have gout symptoms. The goal is to see if ea…

This study looks at kidney transplant patients who take immunosuppressants to prevent organ rejection. It compares the effects of belatacept, a newer drug, against standard anticalcineurins on blood vessel function. The goal is to see if belatacept improves vascular health and re…

This study tests whether a rotigotine skin patch, a drug used for Parkinson's disease, is safe for people with autosomal dominant polycystic kidney disease (ADPKD). ADPKD causes fluid-filled cysts in the kidneys and can lead to kidney failure. The trial will give 120 adults eithe…

This study tests whether taking sildenafil (a drug for erectile dysfunction) daily for 10 months, starting 30 days after surgery, can prevent long-term erectile problems in men treated for rectal cancer with radiation and surgery. The trial includes 188 men aged 18 to 70 who had …

This study tests a personalized approach to treating pemphigus, a rare blistering skin disease. Instead of waiting for a relapse, doctors will use blood tests to measure specific antibodies and give extra rituximab infusions only when those levels rise. The goal is to prevent fla…

This study tests the safety of injecting a patient's own stem cells (from fat tissue) into the thumb joint to treat painful thumb arthritis when standard treatments have failed. The goal is to see if this injection can control the disease and avoid the need for surgery. The trial…

This study tests whether giving different chemotherapy drugs after pancreatic cancer surgery, based on how much tumor remains, can improve survival. About 390 patients who received chemo before surgery will be randomly assigned to one of two drug regimens. The goal is to reduce c…

This study tests whether a simpler treatment for immune thrombotic thrombocytopenic purpura (iTTP) works as well as the standard approach. Instead of daily plasma exchange (an invasive procedure), patients receive plasma infusions, immune-suppressing drugs, and caplacizumab. The …

This Phase 3 trial tests whether the drug apremilast can completely clear painful mouth ulcers in people with severe recurrent aphthous stomatitis (RAS) that hasn't responded to colchicine. About 134 adults will receive either apremilast or a placebo twice daily for 12 weeks, fol…

This study compares two ways to prevent cytomegalovirus (CMV) infection in kidney transplant patients who already carry the virus. One approach gives antiviral drugs to everyone for 3 months, while the other uses immune system tests to decide who needs treatment. The goal is to s…

This study is for people with resistant hypertension, meaning their blood pressure stays high even with three or more medications. Researchers want to see if a drug that blocks endothelin-1, a substance that tightens blood vessels, can improve blood vessel function and lower bloo…

This Phase 3 trial tests whether giving chemotherapy before surgery (neoadjuvant) helps patients with obstructive colon cancer complete their full treatment plan. About 232 adults with stable microsatellite tumors will be randomly assigned to standard care or the new sequence. Th…

This study looks at 60 adults with rapid atrial fibrillation who already have a pacemaker and recently had a heart ablation procedure. Researchers want to see if pacing the heart's natural electrical system (left bundle branch) helps patients exercise better compared to standard …

This study tests whether a personalized medication plan (PPP) can help patients with acute musculoskeletal pain stop taking strong opioids sooner, reducing the risk of dependence. Researchers will compare patients who receive the PPP during hospitalization to those who get standa…

This study tests whether using high-flow oxygen at home can reduce severe COPD attacks or death in 406 patients who have just been hospitalized for a flare-up. Participants receive either high-flow oxygen or standard oxygen therapy. The goal is to see if high-flow oxygen helps th…

This study tests whether taking glutamine, an amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in obese patients. 110 participants will receive either glutamine or a protein powder placebo. Researchers will measure changes …

This study looks at whether a quick swallowing test done by a physical therapist can reliably detect vocal cord paralysis after major lung cancer surgery, compared to the standard scope exam. About 72 adults having lung surgery will take a swallowing test and a scope test right a…

This study aims to see if a dried blood spot test can effectively screen drug users for hepatitis B, hepatitis C, and AIDS. Researchers will enroll 500 former or active drug users. The goal is to find a simpler way to detect these infections in a hard-to-reach population.

This study looks at whether a new, high-resolution probe can better diagnose severe constipation that doesn't get better with standard laxatives. Researchers will compare results from healthy volunteers and patients with suspected colonic inertia. The goal is to improve diagnosis…

This study tests whether adding hip abductor exercises to standard pelvic floor training can reduce urine leaks in women with stress urinary incontinence. About 78 women will be split into two groups: one does only pelvic floor exercises, the other adds hip exercises at home. The…

This study tests whether injecting a local anesthetic (ropivacaine) into the vagina before making the incision for a hysterectomy can reduce pain after surgery. 108 women scheduled for vaginal hysterectomy will be randomly assigned to receive either the anesthetic or a placebo (s…

This study tests whether aromatherapy (ylang ylang essential oil) and music therapy can lower stress in 224 adults undergoing cerebral arteriography, a brain imaging procedure. Participants will receive standard care plus one or both calming techniques. The goal is to see if thes…

This study tests whether high-flow oxygen therapy can improve heart function in people with chronic heart failure who have recently had heart surgery. Researchers will compare it to non-invasive ventilation (a breathing machine) in 30 adults. The goal is to see if the oxygen ther…

This study tests whether a dietary supplement called DIELEN Protect, which contains glutamine and marine peptides, can ease symptoms of irritable bowel syndrome (IBS). One hundred adults with moderate to severe IBS will take either the supplement or a placebo for 8 weeks. Researc…

This study tests whether taking glutamine, a natural amino acid, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D) who also have increased intestinal permeability (leaky gut). About 60 adults will receive either glutamine or a placebo daily …

This study tests whether electrical spinal cord stimulation is safe for people with Parkinson's disease who have a painful, bent-forward posture called camptocormia. Six participants will receive the stimulation and be monitored for side effects for about 10-11 months. The goal i…

This study tests whether a respiratory rehabilitation program (exercise and education sessions over 8 weeks) can improve sleep quality in people with stable COPD. 90 adults aged 50 and older will be randomly assigned to either the rehab program or usual care. Sleep will be measur…

This study tests whether playing a motion-sensor game called TOAP RUN at home can improve walking and balance in people with Parkinson's disease. 80 patients will be split into two groups: one does the game sessions plus usual care, the other just usual care. Researchers will che…

This study tests botulinum toxin (Botox) injections into the rectum to help people with fecal incontinence who haven't improved with standard treatments. Researchers want to understand how the injections work and which patients benefit most. About 21 adults will participate, and …

This study looks at whether a 4-week low-calorie, high-protein diet before bariatric surgery is safe and well-tolerated. Researchers want to see if it reduces liver fat and helps surgeons operate more easily. About 200 people with severe obesity will be split into two groups: one…

This study tests whether adding daily cycling to standard physical therapy helps people recover faster after minimally invasive lung cancer surgery. 184 participants will be randomly assigned to either standard rehab or standard rehab plus 20 minutes of stationary cycling. The ma…

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study looks at whether women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain levels and other gynecological issues in 156 women using an online questionnaire. The goal is to better understan…

This study investigates whether changes in the GBA and PSAP genes are more common in people with multiple myeloma or its precursor condition, MGUS. Researchers will compare the frequency of these gene variants in 300 patients against known population databases. The goal is to bet…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study aims to describe the language, thinking, and behavior patterns in people with MYT1L syndrome, a rare genetic condition that affects development. Researchers will work with 50 French-speaking participants aged 6 and older, using interviews and tests to build a detailed …

This study will screen about 100,000 newborns in Normandy, France for two rare lysosomal storage diseases: MPS1 and Pompe disease. Researchers will take an extra blood sample from each baby to see how many have these conditions. The goal is to understand how common these diseases…

This study looks at whether the 'stickiness' or viscosity of the carotid artery wall differs between people with vascular dementia and those with Alzheimer's disease. Researchers will measure artery wall viscosity in 140 older adults using ultrasound and pressure sensors. The goa…

This study looks at whether using an EEG (a device that measures brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure, compared to the usual nurse assessments. About 47 adults in the ICU will have their sleep …

This early-stage study tests two ways to give fentanyl without needles: a face mask and a nasal spray. Twenty healthy volunteers will receive small doses to see how well the drug enters the body. The goal is to find a faster, easier way to manage pain in emergency rooms without n…

This pilot study tests whether a drug called aprepitant (currently used for nausea) can lower a hormone called aldosterone in people with severe sleep apnea and high blood pressure. The study will enroll 24 adults and measure aldosterone levels before and after taking the drug or…

This study tests whether a specific nerve-sliding exercise, done in a seated slump position, can change how healthy adults perceive pain. Researchers will measure the pressure point where a sensation becomes painful, comparing the nerve-slide to a placebo. The goal is to understa…

This study looks at blood samples from 44 people with thrombotic thrombocytopenic purpura (TTP) to understand how certain immune cells (B and T lymphocytes) react to the ADAMTS13 protein during different stages of the disease. The goal is to find early warning signs that could pr…

This study looks at sexual and gynecological problems that women may face after finishing treatment for rectal cancer. Researchers will survey 15 women in remission about their symptoms using standard questionnaires. The goal is to better understand these long-term effects and id…

This study is testing whether a simple one-minute chair stand test can help doctors predict how well patients will recover from a non-severe pulmonary embolism (a blood clot in the lungs). Researchers will compare the test results with standard risk scores that use blood tests an…

This study looks at the bacteria (microbiomes) in the airways of infants under 2 years old with severe asthma. Researchers will collect blood, nasal swabs, and sputum samples to understand how these microbiomes relate to the disease. The goal is to find new ways to improve care a…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can predict if liver cancer will come back after surgery. Researchers will take blood samples before and after surgery, then at 3 and 6 months, from 150 adults with liver cancer. The goal is …

This study looks at whether a substance called PlGF in the umbilical cord and placenta can act as an early warning sign for brain damage in babies whose mothers drank alcohol during pregnancy. Researchers will compare PlGF levels between 60 pairs of mothers and babies—some with a…

This study is looking at 100 cancer patients who have had chronic itching for over a month while on immunotherapy drugs like pembrolizumab or nivolumab. Researchers want to see if certain antibodies (BP180 and BP230) in the blood are linked to the itching. The goal is to better u…

This study tests a new way to read DNA that may find hidden carriers of spinal muscular atrophy (SMA). Some people carry two copies of the SMN1 gene side by side, making them carriers that standard tests miss. Researchers will take blood samples from 27 adults and use long-read D…

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This study is creating a long-term group of 600 people with irritable bowel syndrome (IBS) to track how the disease changes over time. Participants will fill out questionnaires about their symptoms, quality of life, and habits, and provide stool samples every six months. The goal…

This study takes gut bacteria from women with eating disorders (like anorexia or bulimia) and gives them to mice to see if the mice gain or lose weight differently. The goal is to understand if an unhealthy gut microbiome can influence body weight and eating behavior. It's a basi…

This study tests a new way to measure cardiac output (how much blood the heart pumps) using ultrasound from under the ribs. It involves 50 adults in the ICU who already need an ultrasound. The goal is to see if this new method matches the standard one, potentially making heart mo…

This study follows 200 adults with antiphospholipid syndrome (APS) to see how often blood clots return and how well current treatments work. Researchers will also look at treatment side effects, risk factors, and death rates. No new treatment is being tested; the goal is to gathe…