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Could a nausea drug tame blood pressure in sleep apnea?

NCT ID NCT06462287

Recruiting now Knowledge-focused Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether a drug called aprepitant (currently used for nausea) can lower a hormone called aldosterone in people with severe sleep apnea and high blood pressure. The study will enroll 24 adults and measure aldosterone levels before and after taking the drug or a placebo. The goal is to understand if blocking a nerve signal in the adrenal gland can reduce blood pressure risks in sleep apnea.

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Conditions

The condition(s) this trial relates to.

essential hypertension obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APNEA, OBSTRUCTIVE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHU de Rouen

    RECRUITING

    Rouen, France, 76000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••