Could a needle replace a machine? new study aims to simplify lifesaving iTTP treatment

NCT ID NCT06291025

Recruiting now Disease control Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a simpler treatment for immune thrombotic thrombocytopenic purpura (iTTP) works as well as the standard approach. Instead of daily plasma exchange (an invasive procedure), patients receive plasma infusions, immune-suppressing drugs, and caplacizumab. The goal is to reduce complications and burden while still controlling the disease. About 131 adults with iTTP will take part.

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Conditions

The condition(s) this trial relates to.

acquired thrombotic thrombocytopenic purpura thrombotic microangiopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THROMBOTIC MICROANGIOPATHIES

Contacts and locations

Locations

Ap-Hm La Conception
RECRUITING

Marseille, 13005, France
Ap-Hp Pitie Salpetriere
NOT_YET_RECRUITING

Paris, 75651, France
Ap-Hp Saint Louis
RECRUITING

Paris, 75010, France
Ap-Hp St Antoine
RECRUITING

Paris, 75571, France
CH PAU
NOT_YET_RECRUITING

Pau, 64046, France
CHU NICE
RECRUITING

Nice, 06200, France
Ch Saint-Nazaire
NOT_YET_RECRUITING

Saint-Nazaire, 44606, France
Ch Valenciennes
RECRUITING

Valenciennes, 59322, France
Chru Besanon
RECRUITING

Besançon, 25030, France
Chu Amiens
RECRUITING

Amiens, 80054, France
Chu Angers
RECRUITING

Angers, 49933, France
Chu Bobigny
RECRUITING

Bobigny, 93000, France
Chu Bordeaux
RECRUITING

Bordeaux, 33076, France
Chu Clermont-Ferrand
RECRUITING

Clermont-Ferrand, 63003, France
Chu Edouard Herriot
RECRUITING

Lyon, 69003, France
Chu Lille
RECRUITING

Lille, 59037, France
Chu Limoges
NOT_YET_RECRUITING

Limoges, 87042, France
Chu Martinique
NOT_YET_RECRUITING

Fort-de-France, 97261, Martinique
Chu Montpellier
RECRUITING

Montpellier, 34295, France
Chu Nancy
RECRUITING

Nancy, 54500, France
Chu Nantes
RECRUITING

Nantes, 44093, France
Chu Nimes
RECRUITING

Nîmes, 30029, France
Chu Reims
RECRUITING

Reims, 51092, France
Chu Reunion Sud
RECRUITING

Saint-Pierre, 97448, Reunion
Chu Rouen
RECRUITING

Rouen, 76031, France
Chu Strasbourg
RECRUITING

Strasbourg, 67091, France
Chu Toulouse
RECRUITING

Toulouse, 31000, France
Chu Tours
NOT_YET_RECRUITING

Tours, 37044, France
Hopital Jean Verdie
RECRUITING

Bondy, 93140, France
Reunion Nord
RECRUITING

Saint-Denis, 97400, Reunion

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