Hope for severe mouth ulcer sufferers: new drug trial launches

NCT ID NCT04227314

First seen Feb 19, 2026 · Last updated May 14, 2026 · Updated 10 times

Summary

This study tests if the drug apremilast can completely heal painful mouth ulcers in people with severe recurrent aphthous stomatitis who haven't responded to standard treatment. About 134 adults will receive either apremilast or a placebo for 12 weeks. The goal is to see if the drug can clear all ulcers and improve quality of life.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RECURRENT APHTOUS STOMATITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ap-Hm La Timone

    RECRUITING

    Marseille, 13385, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ap-Hp Avicenne

    RECRUITING

    Bobigny, 93000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ap-Hp Pitie Salpetriere

    RECRUITING

    Paris, 75013, France

    Contact Email: •••••@•••••

    Contact

  • Ap-Hp Pitie-Salpetriere

    NOT_YET_RECRUITING

    Paris, 75013, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • CHU NICE

    RECRUITING

    Nice, 06000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ch Creteil

    RECRUITING

    Créteil, 94010, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ch Le Mans

    RECRUITING

    Le Mans, 72037, France

    Contact Email: •••••@•••••

    Contact

  • Ch Saint-Brieux

    NOT_YET_RECRUITING

    Saint-Brieuc, 22023, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chru Brest

    RECRUITING

    Brest, 29200, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chru Tours

    RECRUITING

    Tours, 37170, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Amiens

    NOT_YET_RECRUITING

    Amiens, 80054, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Bordeaux

    RECRUITING

    Bordeaux, 33076, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Lille

    RECRUITING

    Lille, 59000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Montpellier

    RECRUITING

    Montpellier, 34295, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Nantes

    RECRUITING

    Nantes, 44000, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Reims

    RECRUITING

    Reims, 51092, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Rouen

    RECRUITING

    Rouen, 76031, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Saint-Etienne

    NOT_YET_RECRUITING

    Saint-Etienne, 42055, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chu Toulouse

    RECRUITING

    Toulouse, 31059, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hcl Hopital Edouard Herriot

    RECRUITING

    Lyon, 69003, France

    Contact Email: •••••@•••••

    Contact

  • Hopital Cochin

    RECRUITING

    Paris, 75014, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.