New drug aims to silence painful mouth ulcers
NCT ID NCT04227314
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether the drug apremilast can completely clear painful mouth ulcers in people with severe recurrent aphthous stomatitis (RAS) that hasn't responded to colchicine. About 134 adults will receive either apremilast or a placebo twice daily for 12 weeks, followed by an active treatment period. The main goal is to see if more patients achieve total ulcer remission at 12 weeks with apremilast.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Apremilast (a drug taken as a pill twice daily)
What this could lead to
If it works, this could offer a new treatment option for people with severe, painful mouth ulcers that don't respond to standard therapy.
What could go wrong
This is a Phase 3 trial, but it's still relatively small (134 participants). The drug may not prove more effective than placebo, and side effects like nausea or diarrhea are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ap-Hm La Timone
RECRUITINGMarseille, 13385, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ap-Hp Avicenne
RECRUITINGBobigny, 93000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ap-Hp Pitie Salpetriere
RECRUITINGParis, 75013, France
Contact Email: •••••@•••••
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Ap-Hp Pitie-Salpetriere
NOT_YET_RECRUITINGParis, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU NICE
RECRUITINGNice, 06000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ch Creteil
RECRUITINGCréteil, 94010, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ch Le Mans
RECRUITINGLe Mans, 72037, France
Contact Email: •••••@•••••
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Ch Saint-Brieux
NOT_YET_RECRUITINGSaint-Brieuc, 22023, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chru Brest
RECRUITINGBrest, 29200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chru Tours
RECRUITINGTours, 37170, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Amiens
NOT_YET_RECRUITINGAmiens, 80054, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Bordeaux
RECRUITINGBordeaux, 33076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Lille
RECRUITINGLille, 59000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Montpellier
RECRUITINGMontpellier, 34295, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Nantes
RECRUITINGNantes, 44000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Reims
RECRUITINGReims, 51092, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Rouen
RECRUITINGRouen, 76031, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Saint-Etienne
NOT_YET_RECRUITINGSaint-Etienne, 42055, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Toulouse
RECRUITINGToulouse, 31059, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hcl Hopital Edouard Herriot
RECRUITINGLyon, 69003, France
Contact Email: •••••@•••••
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Hopital Cochin
RECRUITINGParis, 75014, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact