Canker sore

This trial tests whether spirulina, a dietary supplement made from blue-green algae, can reduce the severity and pain of recurrent aphthous ulcers (canker sores). Forty adults with active mouth ulcers will receive either spirulina tablets or a placebo for a set period. Researcher…

This Phase 3 trial tests whether the drug apremilast can completely clear painful mouth ulcers in people with severe recurrent aphthous stomatitis (RAS) that hasn't responded to colchicine. About 134 adults will receive either apremilast or a placebo twice daily for 12 weeks, fol…

This study is testing an oral spray called OROSEDAL to see if it helps relieve pain from sore throats, canker sores, and other minor mouth lesions. About 124 children and adults will use the spray as prescribed and report their pain levels over 6 days. The spray works by forming …

This study tests whether an oxygenated gel can reduce pain and speed up healing of canker sores (aphthous ulcers) compared to a standard steroid gel. Thirty adults with a single small ulcer will apply the gel twice daily for 7 days. Researchers will check pain levels and ulcer si…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…