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Blue-Green algae vs. painful mouth sores: a trial puts spirulina to the test

NCT ID NCT07723612

Recruiting now Disease control Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether spirulina, a dietary supplement made from blue-green algae, can reduce the severity and pain of recurrent aphthous ulcers (canker sores). Forty adults with active mouth ulcers will receive either spirulina tablets or a placebo for a set period. Researchers will track ulcer size, pain levels, and changes in oral bacteria and inflammatory markers to see if spirulina offers any benefit over standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Spirulina tablets (a dietary supplement from blue-green algae)
What this could lead to
If spirulina works, it could offer a natural, safe option to reduce pain and speed healing of recurrent mouth ulcers.
What could go wrong
This is a small early-stage trial with only 40 participants. Spirulina is a supplement, not a drug, so its effects may be modest or no better than placebo.

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Conditions

The condition(s) this trial relates to.

aphthous stomatitis canker sore Oral Ulcer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MOUTH ULCER RECURRENT APHTHOUS STOMATITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Fourth Affiliated Hospital of Zhejiang University School of Medicine

    RECRUITING

    Yiwu, Zhejiang, 322000, China

    Contact

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