Stomatitis

Researchers are testing whether a toothpaste containing isopropyl methyl phenol reduces plaque buildup and gum bleeding better than a regular fluoride toothpaste. The 12-week study enrolls 120 Chinese adults with plaque-induced gingivitis. Dentists measure gum bleeding at weeks 2…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This trial asks whether using an electric flosser alongside a manual toothbrush reduces plaque and gum inflammation (gingivitis) better than brushing alone. About 80 adults aged 18 to 70 with mild gum issues will use either the electric flosser plus toothbrush or just a manual to…

This study tests whether an oil pulling mouthwash can reduce dental plaque, gum inflammation, and harmful bacteria better than a standard mouthwash or a placebo rinse. Healthy adults aged 18 to 70 with mild to moderate gum inflammation will use one of three rinses for a period. R…

This study tests whether a probiotic lozenge containing a special strain of Streptococcus salivarius (SALI-10) can reduce gum inflammation and bad breath. Sixty adults with gingivitis will take the lozenge or a placebo twice daily for four weeks. The goal is to see if the probiot…

This trial tests whether spirulina, a dietary supplement made from blue-green algae, can reduce the severity and pain of recurrent aphthous ulcers (canker sores). Forty adults with active mouth ulcers will receive either spirulina tablets or a placebo for a set period. Researcher…

This study tests the drug lenalidomide in 42 adults with Behçet's syndrome who have stubborn mouth ulcers. Participants take 10 mg of lenalidomide daily for 12 weeks, then stop for 4 weeks of observation. The main goal is to see if the ulcers completely disappear by week 12.

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This study tests a new cleaning method (air-polishing with erythritol) against standard cleaning (ultrasound) to prevent white spots on teeth and gum inflammation in 60 teens aged 12-16 who are getting braces. Participants will be followed for 2 years to see which method works be…

This study tests whether using a smart electric toothbrush with an app and flossing can control gum inflammation as well as getting a professional dental cleaning. 92 adults with mild gum disease will be split into two groups: one uses the smart toothbrush alone, the other gets a…

This study tests whether a mouthwash made from black mulberry extract can improve gum health when used along with standard dental cleaning (scaling and root planing). Thirty adults with gingivitis will be split into two groups: one gets cleaning alone, the other adds the mulberry…

This 8-week study tests whether using a compact water flosser (Bixdo A30 Pro) along with regular toothbrushing reduces gum inflammation and plaque better than brushing alone. About 165 adults with plaque-induced gingivitis will be randomly assigned to either use the water flosser…

This study tests whether a special delayed-connection surgery (Turnbull-Cutait) can help people with low rectal cancer avoid a permanent colostomy bag better than the standard surgery with a temporary stoma. About 520 adults aged 18-75 with rectal cancer will be randomly assigned…

This study tests whether adding a daily probiotic tablet and a coenzyme Q10 toothpaste to standard gum cleaning can improve oral health in pregnant women. Forty pregnant women will be split into two groups: one gets the probiotic plus Q10 toothpaste, the other gets only the Q10 t…

This 6-month study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health in adults with gingivitis. Participants will brush and rinse twice daily and visit the clinic every 3 months. The goal is to see if the rinse helps control gum inf…

This Phase 3 trial tests whether the drug apremilast can completely clear painful mouth ulcers in people with severe recurrent aphthous stomatitis (RAS) that hasn't responded to colchicine. About 134 adults will receive either apremilast or a placebo twice daily for 12 weeks, fol…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

Researchers in Italy compare three toothpastes over six months: one with stannous fluoride, one with 67% bicarbonate, and Colgate Cavity Protection. They enroll 120 adults aged 18 to 70 who have mild gum inflammation and plaque buildup. Dentists check gum bleeding, gum inflammati…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

Researchers are testing whether a mouthwash made from copaiba oil, combined with low-level laser therapy, can prevent oral mucositis in people undergoing autologous hematopoietic stem cell transplantation. Oral mucositis is a common and painful side effect of the high-dose chemot…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This study tests if rinsing with virgin coconut oil can prevent severe mouth sores in children and young adults (ages 7-26) getting a bone marrow transplant. About 60 participants will either use standard mouth rinses or add coconut oil to their routine. Researchers will compare …

This study tests whether a dexamethasone mouthwash can prevent moderate to severe mouth sores caused by chemotherapy in adults with cancer. Participants use the mouthwash four times daily during chemo for up to 8 weeks. Researchers compare their outcomes to a historical group to …

This study tests whether a one-time infusion of amimestrocel, made from donated umbilical cord cells, can prevent severe mouth and gut sores in people receiving a stem cell transplant. About 22 adults will get the infusion before their transplant, and researchers will monitor for…

This study tests whether a zinc-based spray (Gel X) can prevent painful mouth sores caused by radiation therapy for head and neck cancer. About 130 adults receiving radiation will use either the zinc spray or a sodium bicarbonate rinse. The goal is to see if the spray reduces how…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This study tests whether low-level laser therapy can prevent severe mouth sores (mucositis) caused by chemotherapy in children and young adults aged 4 to 25. The laser is a painless, non-heating light applied to the mouth before chemotherapy. The trial is double-blind and placebo…

This study tests a daily light therapy device placed inside the mouth to prevent severe mouth sores in people receiving a stem cell transplant. Twenty adults will use the device for about 2-3 minutes each day from the start of their conditioning chemotherapy through day 20 after …

Gingivitis is an early, reversible form of gum disease driven by inflammation and oxidative stress. Standard treatment is a thorough professional cleaning, but oxidative stress can linger afterward. This trial tests whether taking alpha-lipoic acid, a dietary antioxidant suppleme…

This study tests whether an oxygenated gel can reduce pain and speed up healing of canker sores (aphthous ulcers) compared to a standard steroid gel. Thirty adults with a single small ulcer will apply the gel twice daily for 7 days. Researchers will check pain levels and ulcer si…

This phase 3 trial tests whether a lozenge called BupiZenge, which contains the long-acting painkiller bupivacaine, can relieve mouth pain from radiation therapy better than the standard lidocaine rinse. About 150 adults with head and neck cancer will be randomly assigned to one …

Researchers compare two mouthwashes, rebamipide and betamethasone, for treating recurrent oral aphthous ulcers. The trial enrolls 46 adults aged 18 to 70 who have active mouth ulcers and a history of recurrent ulcers. Participants are randomly assigned to one of the two mouthwash…

Researchers are testing whether adding saline or black mulberry syrup to standard sodium bicarbonate mouth care reduces the severity of oral mucositis in children aged 6 to 18 who are receiving chemotherapy. Participants are randomly assigned to one of three mouth-care routines a…

This study tests if a steroid mouthwash can prevent or reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 100 adults with advanced breast or lung cancer will use the mouthwash and be monitored for 12 weeks. The goal is to see if this simple step…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This phase II trial tests whether adding BMX-001 to standard symptom management can reduce severe mouth sores in head and neck cancer patients receiving chemoradiation. About 98 participants will receive either BMX-001 or a placebo alongside usual care. The goal is to see if BMX-…

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This trial tests whether alpha-lipoic acid, a powerful antioxidant, can prevent oral mucositis—painful mouth sores—caused by the chemotherapy drug 5-fluorouracil in colorectal cancer patients. Half of the 50 participants will take alpha-lipoic acid twice daily for six months, whi…

This phase II trial tests whether a plant-derived supplement called chlorophyllin can reduce severe mouth sores caused by high-dose radiation given before a stem cell transplant. People aged 12 to 65 with blood cancers who need total body irradiation as part of their transplant p…

This study tests whether taking taurine granules before daily radiation can reduce painful mouth sores and skin burns in 160 head and neck cancer patients. Half get taurine, half get a placebo, and researchers track side effect severity. If effective, it could offer a simple, low…

This study tests a mouth rinse called MucoLock for people with ongoing mouth pain or burning sensation (stomatitis). About 25 adults will swish the rinse for 5 minutes, three times a day, for 28 days. Researchers will measure changes in pain scores and quality of life to see if t…

This clinical trial tests whether a doxepin solution spray can relieve severe breakthrough pain when swallowing, a common side effect of radiation therapy for nasopharyngeal carcinoma. About 178 patients will be randomly assigned to receive either the doxepin spray or a placebo s…

This study is testing an oral spray called OROSEDAL to see if it helps relieve pain from sore throats, canker sores, and other minor mouth lesions. About 124 children and adults will use the spray as prescribed and report their pain levels over 6 days. The spray works by forming …

This study tests whether a special toothpaste can improve gum inflammation (gingivitis) in adults. Sixty participants with moderate gum inflammation will use either the test toothpaste or a regular one for 4 weeks. Dentists will check gum health at the start and end to see if the…

This phase 3 trial tests whether Houyanqing Oral Liquid, a Chinese herbal mix, can prevent or reduce severe mouth sores caused by radiation therapy in 386 nasopharyngeal cancer patients. Participants take the liquid four times daily during radiation, alongside standard care. The …

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests whether a mobile app that sends daily push notifications can help teenagers wearing braces improve their oral hygiene. Braces make it harder to clean teeth, leading to plaque buildup and gum problems. Researchers will compare three groups: app with reminders, app…

This study tests a traditional Chinese herbal oral solution and mouthwash to see if they can shorten the time head and neck cancer patients suffer from severe mouth sores caused by radiation therapy. About 128 adults aged 18-65 with non-metastatic head and neck cancers will recei…

This phase 2 trial tests whether a traditional Chinese medicine oral liquid and mouthwash can prevent or reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 118 adults aged 18-65 will receive either the herbal treatment or a placebo along…

This study tests whether applying medical ozone gas to mouth sores can reduce pain and severity in people undergoing radiation or chemotherapy for head and neck cancer. Fifty participants will receive ozone therapy, and half will also use a special toothpaste and mouthwash at hom…

This study tests whether high-level laser therapy can help manage oral mucositis—painful mouth sores—in children under 18 who are having a bone marrow transplant. Fourteen participants will receive either laser treatment or standard mouth care (chlorhexidine and sodium bicarbonat…

This study tests if a special light treatment, called photobiomodulation, can reduce the severity and frequency of painful mouth sores in oral cancer patients receiving radiation therapy. About 30 adults who have had surgery for oral cancer will receive the light treatment five t…

This study tests whether a pure green tea mouthwash can reduce dental plaque and gum inflammation better than a placebo or essential oils mouthwashes like Listerine. About 44 healthy adults will rinse with their assigned mouthwash twice daily for 3 weeks, avoiding all other oral …

This study tests whether gargling with olive oil can reduce painful mouth sores caused by radiation or chemotherapy in head and neck cancer patients. About 120 adults will either use olive oil mouthwash or receive standard care for 12 weeks. Researchers will track soreness, dry m…

This study tests whether a hydrogen peroxide mouth rinse called OROXID can help treat gingivitis, a common gum inflammation. About 90 adults with mild gum disease will use the rinse twice daily for 4 weeks, alongside regular brushing. Researchers will measure changes in gum infla…

This study tests whether taking rice bran supplements can reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 80 adults receiving radiation will take rice bran during treatment to see if it lessens pain and improves quality of life. The g…

This study tests whether applying low-level laser light to the gums after tooth extraction and socket preservation can improve healing and reduce pain. About 39 adults will receive either standard care or standard care plus laser treatment on days 1, 3, and 7 after surgery. Resea…

Researchers at Mahidol University are studying how common high body mass index and periodontitis are among Thai adults aged 18 to 59. Both conditions involve chronic low-grade inflammation, and the team wants to see whether they tend to appear together in this age group. About 93…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

Researchers are testing whether proteins in gum crevicular fluid can serve as early signals of tissue recovery after brushing with a stannous fluoride toothpaste. Twenty healthy participants use either the stannous fluoride toothpaste or a regular fluoride toothpaste twice daily …

This study looks at how inflammation in the gums affects the body's immune response during wound healing after a tooth is pulled. Researchers will measure gum health before extraction, take small tissue samples right after and again two weeks later, and check healing at three mon…

This study looks at how fixed versus removable orthodontic retainers influence the types of bacteria living in the gum pockets and overall gum health. Ten adults who have finished braces will be split into two groups: one gets a fixed retainer bonded to the back of the teeth, the…

This study examines a possible connection between gum disease and chronic neck pain. Researchers will compare neck pain intensity and daily disability among adults aged 30-55 with healthy gums, gingivitis, or periodontitis. Participants complete pain scales and questionnaires to …

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study looks at fluid from the gums of 80 people with gingivitis—half children aged 8-12, half young adults aged 15-24. Researchers will measure inflammation markers to see if they differ by age. The goal is to understand how gum disease develops during growth and puberty.

This study collects dental plaque and checks oral health in 100 adults with high plaque levels. Half have mild gum inflammation, half have moderate-to-severe gingivitis. Researchers will compare the types of bacteria in plaque to understand why some people develop gum disease and…

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of people with and without gum disease. Researchers will collect spit and plaque samples from 120 adults and look at them under a microscope. The goal is to learn i…

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early…

This study looks at two proteins, Gas6 and sMerTK, in the fluid around teeth to see if they differ between healthy gums, gingivitis, and periodontitis. Researchers will collect samples from 90 adults and measure these proteins. The goal is to better understand the biology of gum …

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…

This study uses a special high-frequency ultrasound to take detailed images of gum tissue. Researchers will compare healthy gums to gums with gingivitis (early gum disease) to see if the ultrasound can detect inflammation. About 40 adults will participate, and the goal is to find…

This study looks at how different oral hygiene routines (including mouthwash) affect gum health, mouth bacteria, and inflammation in people with gingivitis. About 250 adults will use assigned products twice daily for 4 weeks, then stop for 2 weeks to see how their gums and microb…

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria tha…

This study is looking at whether certain markers in blood and saliva can predict how well people with gum disease heal after non-surgical treatment. Researchers will measure these markers in 180 adults with healthy gums, gingivitis, or advanced periodontitis before and after trea…

This study aims to develop a better way to measure oral health using photographs and imaging software, rather than traditional dental exams. About 275 adults will use different toothpastes or mouthwashes for up to 6 months, and researchers will track plaque levels, gum health, an…

This study looks at how the natural bacteria in your mouth might influence the effectiveness of radiation therapy for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to analyze the bacteria and viruses present. T…