Cure My Disease

Don't miss your cure!

 Log in / Sign up

New lozenge aims to ease radiation mouth sores for hours

NCT ID NCT07672236

Recruiting now Symptom relief Sponsor: OncoZenge AB Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 4 times

Summary

This phase 3 trial tests whether a lozenge called BupiZenge, which contains the long-acting painkiller bupivacaine, can relieve mouth pain from radiation therapy better than the standard lidocaine rinse. About 150 adults with head and neck cancer will be randomly assigned to one of the two treatments. The main goal is to measure pain reduction over three hours after taking the medicine on the last day of radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bupivacaine lozenge (BupiZenge)
What this could lead to
If it works, this could provide longer-lasting pain relief for mouth sores caused by radiation, reducing the need for strong opioids.
What could go wrong
This is still a trial, so results may not show a clear benefit over lidocaine. Pain relief varies per person, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HEAD NECK CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma hypopharynx squamous cell carcinoma nasopharyngeal carcinoma oral cavity squamous cell carcinoma oropharynx squamous cell carcinoma stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD NECK CANCER ORAL MUCOSITIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Helse Bergen HF

    RECRUITING

    Bergen, 5021, Norway

  • Herlev Hospital

    NOT_YET_RECRUITING

    Herlev, 2730, Denmark

  • Karolinska University Hospital

    RECRUITING

    Stockholm, SE-17164, Sweden

  • Medical Center - University Of Freiburg

    NOT_YET_RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Næstved Hospital

    RECRUITING

    Næstved, 4700, Denmark

  • Oslo University Hospital HF

    RECRUITING

    Oslo, 0379, Norway

  • Rigshospitalet, Copenhagen University Hospital

    RECRUITING

    Copenhagen, 2100, Denmark

  • University Hospital Cologne (Universitätsklinikum Köln AöR)

    NOT_YET_RECRUITING

    Cologne, 50937, Germany

  • University Hospital Frankfurt (AöR)

    NOT_YET_RECRUITING

    Frankfurt am Main, 60596, Germany

  • University Hospital Schleswig-Holstein (AöR)

    NOT_YET_RECRUITING

    Kiel, 24105, Germany

  • University Hospital Tübingen (AöR)

    NOT_YET_RECRUITING

    Tübingen, 72076, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.