HEAD & NECK CANCER

This study tests whether giving a mix of two drugs (nimotuzumab and toripalimab) plus chemotherapy before surgery can help eliminate tonsil cancer cells in people with advanced disease. About 10 adults with resectable tonsil cancer will receive the treatment and then have surgery…

This study tests a new treatment for people with high-risk head and neck cancer who cannot receive the standard chemotherapy drug cisplatin. After surgery, patients receive radiation therapy combined with a targeted drug (nimotuzumab), followed by an immunotherapy drug (benmelsto…

This early-phase study tests a new drug, VLPONC-01, injected directly into head and neck tumors to see if it's safe and can shrink tumors. About 41 adults with advanced head and neck cancer will receive the injection alone or with an immunotherapy drug (pembrolizumab). The goal i…

This study tests whether adding the targeted drug nimotuzumab to standard radiation therapy helps control advanced head and neck cancer better than radiation alone. It is for 335 adults whose cancer has spread locally but cannot have platinum chemotherapy. The main goal is to see…

This study tests a weekly treatment of two chemotherapy drugs (carboplatin and paclitaxel) plus an immunotherapy drug (pembrolizumab) in 32 people with advanced head and neck cancer that has spread. It is for patients who cannot take the standard drug 5-fluorouracil. The goal is …

This early-phase study tests a new drug (RiMO-301) combined with targeted radiation and an immunotherapy drug (PD-1 inhibitor) in people with advanced head and neck cancer that cannot be removed by surgery. The goal is to find a safe dose and see if the treatment can shrink tumor…

This study tests a new antibody drug, OM-RCA-01, in people with advanced cancers that have a specific protein called FGFR1. The goal is to see if the drug is safe and can slow tumor growth. About 58 adults with kidney, lung, prostate, breast, or head & neck cancer will receive th…

This study is testing whether a detailed PET-CT scan (called micro-PET-CT) can accurately show the edges of head and neck cancers during surgery. Ten adults with operable tumors will receive the scan, and the results will be compared to standard lab analysis of the removed tissue…

This study looks at whether a special ultrasound using a contrast agent (Sonazoid) can find the first lymph node where cancer might spread, called the sentinel node, as accurately as the current radioactive method. About 91 adults with melanoma, breast cancer, or head & neck canc…

This early study is testing a new imaging agent called FL-261 to see if it can safely and accurately detect and stage several types of cancer, including lung, colorectal, and head & neck cancers. The agent targets a protein (c-MET) found on many cancer cells but not on most healt…

This early-stage study tests whether a precise ultrasound beam can be used to create a tiny lesion in the brain's pain center to relieve severe, opioid-resistant pain in people with head, neck, or brachial cancer. About 20 adults aged 18-85 will take part. The goal is to check sa…

This study looks at whether a special PET scan taken 6 weeks after starting immunotherapy can predict how well the treatment will work later. It involves 25 adults with advanced head and neck cancer who are starting a drug called pembrolizumab. The goal is to see if early changes…

This study looks at how much dentists and head and neck cancer patients know about dental care during cancer treatment. About 132 participants will fill out a questionnaire before and after reading simple, guideline-based information. The goal is to see if this information helps …

This study is for people with laryngeal dysplasia, a precancerous throat condition. Researchers will analyze tissue samples to find genetic and immune changes that might predict progression to cancer. The goal is to better understand the disease, not to test a new treatment.