New cocktail aims to shrink head and neck tumors before surgery
NCT ID NCT07601737
First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 3 times
Summary
This phase II trial tests whether adding the targeted drug nimotuzumab to immunotherapy and chemotherapy before surgery can improve outcomes for people with locally advanced head and neck cancer. About 182 participants will receive the combination or standard treatment. The main goal is to see if it increases the chance of being cancer-free after two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nimotuzumab combined with tislelizumab (or pembrolizumab), albumin-bound paclitaxel (or docetaxel), and cisplatin (or carboplatin)
- What this could lead to
- If successful, this could lead to a more effective neoadjuvant treatment for locally advanced head and neck cancer, potentially improving survival and reducing recurrence.
- What could go wrong
- This is an early phase II trial with a modest number of participants. The combination may cause significant side effects, and results may not generalize to all patients or stages of disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shanghai First People's Hospital
RECRUITINGShanghai, China
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