Shanghai General Hospital, Shanghai Jiao Tong University School Of Medicine

This study looks at whether it is safe to avoid antibiotics before a specific type of kidney stone surgery in patients at low risk for infection. About 500 adults aged 18-75 with small kidney stones will be randomly assigned to receive either no antibiotics or a single dose befor…

This early-phase trial tests a personalized cell therapy for people with relapsed or refractory EBV-positive lymphoma who have a specific genetic marker (HLA-A11:01). The treatment uses the patient's own immune cells, modified to target the Epstein-Barr virus driving their cancer…

This early-phase study tests a gene therapy called LX107 for people with a rare inherited eye disease that causes vision loss. The treatment is given as an injection under the retina and aims to improve vision and slow disease progression. The study will enroll 13 adults and chil…

This early-stage study tests a gene therapy called LX111 for diabetic macular edema, a condition that causes vision loss from swelling in the back of the eye. About 32 adults who have already responded to standard anti-VEGF injections will receive a single shot of LX111 in one ey…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will enroll 56 adults with Parkinson's to receive rTMS and monitor changes in motor function and sleep quality. The …

This study tests whether taking krill oil supplements for 3 months can reduce harmful deposits (drusen) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil capsules or a placebo daily. The goal is to…

This early study tests a new gene therapy called LX111 for people with wet age-related macular degeneration (nAMD). The goal is to see if a single injection into the eye can safely control the disease and reduce the need for frequent anti-VEGF injections. Ten participants aged 50…

This study looks at people with peripheral T-cell lymphoma whose cancer went away after their first treatment. It compares two options: getting a stem cell transplant using their own cells or simply being watched closely. The goal is to see which approach helps keep the cancer fr…

This study tests a new combination of drugs (venetoclax, azacitidine, and homoharringtonine) followed by a stem cell transplant in people aged 18-55 with intermediate or high-risk acute myeloid leukemia (AML). The goal is to see if this approach improves survival and reduces the …

This study is for men with metastatic hormone-sensitive prostate cancer (mHSPC) whose cancer still shows active spots on a special PET scan after 8 months of hormone therapy. It tests whether adding targeted local treatment (like radiation) to continued hormone therapy can delay …

This study tests whether a combination of two drugs, cidabenamine and azacitidine, can keep high-risk peripheral T-cell lymphoma from coming back after a stem cell transplant. About 40 adults aged 18 to 70 will receive this maintenance therapy. The goal is to improve survival and…

This study is for people with peripheral T-cell lymphoma whose cancer did not shrink or got worse after standard chemotherapy. It compares two approaches: a donor stem cell transplant (allogeneic HSCT) or other rescue treatments. The goal is to see which option helps patients liv…

This early-stage trial tests a new treatment for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses specially engineered immune cells (CLL-1 CAR-NK cells) designed to find and attack leukemia cells. The main goals …

This study looks at how safe and effective the drug adebrelimab is for people with advanced small cell lung cancer. Researchers will track side effects and how long patients live or stay cancer-free. About 500 participants will be observed in real-world conditions, not in a stric…

This early-phase study tests a new treatment for people with chronic graft-versus-host disease (cGVHD) that hasn't responded to standard therapy. The treatment uses immune cells (Treg cells) from the original stem cell donor, combined with a low dose of interleukin-2, to help con…

This study looks at two types of stem cell transplants for people with a rare blood cancer called peripheral T-cell lymphoma that only partially improved after initial treatment. One group receives their own stem cells, while the other gets stem cells from a healthy donor. The go…

This study tests whether a daily pill called golidocitinib can help keep peripheral T-cell lymphoma from coming back after successful first chemotherapy. About 136 adults who responded to initial treatment but cannot have a stem cell transplant will receive either the study drug …

This study tests whether adding a new oral drug (ivarmacitinib) to standard medications can prevent acute graft-versus-host disease (GVHD) in 82 adults receiving a stem cell transplant from a female donor who has given birth. GVHD is a serious complication where donor cells attac…

This study is testing a new way to measure liver scarring (fibrosis) using a special ultrasound during an endoscopy. It involves 65 adults with chronic liver disease who are already scheduled for a liver biopsy. The goal is to see if this new method is as accurate as a biopsy and…

This study compares a new superpulse thulium fiber laser to the standard holmium laser for breaking up kidney stones during a scope procedure. About 136 adults aged 18-70 with stones 6-20mm will be randomly assigned to one laser. The goal is to see which laser clears more stones,…

This study tests whether an app that collects patient-reported data (like pain, appetite, and weight) combined with artificial intelligence can help doctors better assess and support nutrition in 200 adults who have had surgery for pancreatic cancer. The goal is to see if this ap…