Shanghai General Hospital, Shanghai Jiao Tong University School Of Medicine

This early-phase study tests a new radioactive drug (BRP-020063) in 10 people with advanced solid tumors that have spread. The drug is used first for imaging to find tumors, then a low dose is given to see if it's safe and how it travels in the body. The goal is to gather informa…

This phase II trial tests whether adding the targeted drug nimotuzumab to immunotherapy and chemotherapy before surgery can improve outcomes for people with locally advanced head and neck cancer. About 182 participants will receive the combination or standard treatment. The main …

This study tests whether adding a new oral drug (ivarmacitinib) to standard medicines can prevent a serious complication called graft-versus-host disease (GVHD) after a stem cell transplant from a female donor who has given birth. About 82 adults with blood cancers will receive t…

This study tests whether adding targeted local treatments (like radiation or surgery) to standard hormone therapy can slow disease progression in men with metastatic hormone-sensitive prostate cancer. Doctors will use PSMA PET/CT scans to find remaining active tumors after initia…

This study is for people with peripheral T-cell lymphoma whose cancer did not shrink or got worse after standard first treatment. It compares a stem cell transplant from a donor to other rescue treatments. The goal is to see which approach helps people live longer and control the…

This early-phase study tests a gene therapy called LX111 for diabetic macular edema (DME), a condition that causes vision loss due to swelling in the retina. About 32 adults with DME will receive a single injection into the eye. The main goals are to check safety and see if it he…

This early study tests a single injection of LX111 gene therapy in 10 people aged 50 or older with wet age-related macular degeneration (nAMD). The goal is to see if it is safe and can help control the disease, possibly reducing the need for frequent eye injections. Participants …

This early-phase study tests a gene therapy called LX107 for people with a rare inherited eye disease caused by mutations in the AIPL1 gene. The treatment is given as an injection under the retina to try to improve vision and slow disease progression. The study will include 13 ad…

This phase 2 trial tests a three-drug combination (venetoclax, azacitidine, and homoharringtonine) followed by a stem cell transplant in 56 adults aged 18-55 with newly diagnosed, intermediate- or high-risk acute myeloid leukemia (AML). The goal is to see if this approach improve…

This study looks at how well the drug adebrelimab works and how safe it is for people with advanced small cell lung cancer in everyday medical practice. Researchers will track 500 patients to see side effects, survival time, and how long the cancer stays under control. The goal i…

This Phase 3 trial tests whether the drug golidocitinib can help people with peripheral T-cell lymphoma (PTCL) stay in remission longer after their first round of chemotherapy. About 136 patients who responded to chemo will receive either golidocitinib or a placebo pill every oth…

This study tests whether combining two drugs, cidabenamine and azacitidine, can stop high-risk peripheral T-cell lymphoma from progressing after a stem cell transplant. About 40 adults aged 18 to 70 will receive the drug combo as maintenance therapy. The goal is to see if it impr…

This study looks at whether a stem cell transplant (using a patient's own cells) after successful first treatment can help control peripheral T-cell lymphoma. About 160 people will either get the transplant or just be monitored. The goal is to see if the transplant delays the can…

This study compares two types of lasers used to break up kidney stones during a minimally invasive procedure called ureteroscopy. One laser uses a superpulse thulium fiber (sTFL), the other is a standard holmium laser. Researchers will enroll 136 adults aged 18–70 with kidney sto…

This study tests whether taking krill oil capsules daily for 3 months can reduce drusen (fatty deposits) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil or a placebo. The main goal is to see if t…

This study compares two types of stem cell transplants for people with peripheral T-cell lymphoma whose cancer only partially responded to first treatment. One group receives their own stem cells, the other receives cells from a matched donor. The goal is to see which approach le…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will give 56 people with Parkinson's either real or sham rTMS and track changes in movement and sleep. The goal is t…

This early-phase trial tests whether a personalized immune cell therapy called anti-EBV TCR-T cells is safe for people with relapsed or refractory EBV-positive lymphoma who have a specific genetic marker (HLA-A11:01). The treatment involves taking a patient's own T cells, enginee…

This early-stage trial is testing a new treatment made from a person's own immune cells, called CLL-1 CAR-NK cells, for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The study aims to see if the treatment is safe and tolerable, …

This early-phase trial tests whether infusing specially prepared donor immune cells (Treg cells) along with low-dose interleukin-2 can safely treat refractory chronic graft-versus-host disease (cGVHD), a serious complication after stem cell transplants. The study will enroll 18 a…

This study tests a new endoscopic ultrasound method (EUS-SWQ) to measure liver stiffness and diagnose liver fibrosis (scarring) in people with chronic liver disease. Researchers will compare EUS-SWQ results with standard liver biopsy and FibroScan in 65 adults. The goal is to see…

This study looks at whether it's safe to skip antibiotics before a specific type of kidney stone surgery in patients at low risk for infection. The surgery uses a special suction tool to remove stones. Researchers will compare infection rates between those who get antibiotics and…

This study tests whether acupuncture at specific points before and after lung cancer surgery can improve sleep and reduce long-term pain. About 316 patients will receive either real or sham acupuncture alongside standard care. The goal is to see if this simple, low-risk treatment…

This study tests a new, non-invasive brain stimulation method called transcranial temporal interference stimulation (tTIS) for people with Parkinson's disease. The treatment targets a deep brain area involved in movement control. 32 participants will receive either real or sham s…

This study looks at why some women develop stress urinary incontinence (leaking urine when coughing or sneezing) after surgery for pelvic organ prolapse. Researchers will follow 382 women who have no incontinence before surgery, using phone calls and questionnaires at 3, 6, and 1…

This study is testing whether an AI-powered mobile app can help assess and improve nutrition in 200 patients who have had surgery for pancreatic cancer. The app collects data on symptoms like pain, appetite, and weight, and uses artificial intelligence to guide follow-up care. Th…