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Zapping the brain during deep sleep may slow Parkinson's

NCT ID NCT06002581

Disease control Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will give 56 people with Parkinson's either real or sham rTMS and track changes in movement and sleep. The goal is to find a new way to delay the disease without drugs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a non-drug way to slow Parkinson's progression by improving deep sleep.
What could go wrong
This is a small, early-phase study with only 56 people. It tests a device, not a drug, and may not show clear benefits or be widely applicable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Meet the clinically definite or clinically probable PD according to the MDS 2015 version. 2. Chinese Han population (three generations), age greater than or equal to 50 years old, less than or equal to 80 years old, male or female. 3. Hoehn-Yahr stages 1-4. 4. The dose of levodopa drug therapy was stable three weeks before enrollment and during the follow-up period. 5. Right-handed. 6. The patient signed a written informed consent. Exclusion Criteria: 1. Any form of Parkinsonism other than primary PD. 2. Those who have received neurosurgical intervention or stereotaxic brain surgery for PD, or have previously received TMS treatment. 3. Cognitive dysfunction (MMSE ≤ 24 points) or those who cannot cooperate with the scale score. 4. Persons with mental disabilities. 5. Pregnant women. 6. There are contraindications for rTMS treatment. 7. There are contraindications for MRI examination. 8. Baseline PSG suggests other sleep disorders such as moderate to severe OSAS; BMI\>=30. 9. Patients who are addicted to alcohol, taking SSRIs, TCAs, sedative hypnotics, histamine antagonists and other drugs and food that may affect NREM and REM sleep structure. 10. Those who are unwilling to participate in the study or unable to sign the informed consent form; and other circumstances that the researcher considers inappropriate to participate in the study. \-

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Conditions

The condition(s) this trial relates to.

Disease Progression Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Shanghai Jiao Tong University School of Medicine

    RECRUITING

    Shanghai, Shanghai Municipality, 200040, China

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