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Plant pigment could soothe Radiation's harsh side effect in blood cancer treatment

NCT ID NCT07709195

Recruiting now Symptom relief Sponsor: Tata Memorial Centre Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 22, 2026 · Updated 3 times

Summary

This phase II trial tests whether a plant-derived supplement called chlorophyllin can reduce severe mouth sores caused by high-dose radiation given before a stem cell transplant. People aged 12 to 65 with blood cancers who need total body irradiation as part of their transplant preparation take chlorophyllin daily starting two days before radiation and continuing for four weeks after transplant. Researchers track how many develop severe mouth sores, how long they last, and whether patients need extra nutrition or pain medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sodium copper chlorophyllin, a green pigment derived from plants, taken as a tablet or oral suspension
What this could lead to
If it works, this could offer a simple, low-cost way to prevent severe mouth sores in patients undergoing radiation before a stem cell transplant.
What could go wrong
This is a small, early-phase trial with only 17 participants, so results may not apply to everyone. The supplement may not reduce mouth sores more than standard care.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC MALIGNACIES HEMATOLOGICAL MALIGNANCIES HEMATOPOIETIC STEAM CELL TRANSPLANTATION (HCT) HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) ORAL MUCOSITIS TOTAL BODY IRRADIATION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Advanced Centre for Treatment, Research and Education in Cancer

    RECRUITING

    Navi Mumbai, Maharashtra, 410210, India

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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