Tata Memorial Centre

This trial tests whether a compound from the herb ashwagandha, called withaferin A, can help prevent graft-versus-host disease (GvHD) in people receiving a stem cell transplant for blood cancer. GvHD is a serious complication where donated immune cells attack the recipient's body…

This trial investigates whether giving a reduced dose of the drug cyclophosphamide after a half-matched stem cell transplant can prevent graft-versus-host disease (GVHD) while causing fewer side effects. The standard dose often leads to infections and slow immune recovery. Resear…

This phase 2 trial tests whether leflunomide, a drug typically used for arthritis, can prevent cytomegalovirus (CMV) reactivation in adults with blood cancers who receive a half-matched stem cell transplant. Participants take leflunomide daily for up to six months after transplan…

This phase 2 trial tests whether a standardized extract from the ashwagandha plant, called Withaferin-A, can help people who develop graft-versus-host disease after a stem cell transplant and whose condition does not improve with steroids. The study enrolls 34 patients aged 12 an…

This study is for older adults (50+) with aggressive brain tumors (GBM) who are not healthy enough for surgery. It tests whether a shorter course of high-dose radiation, guided by a PET scan to target the most active tumor areas, can help them live longer compared to the current …

This phase 3 trial tests whether brain tumor patients who have been seizure-free for 6 months on levetiracetam can safely stop the drug earlier than the standard 2-3 years. 604 adults with primary brain tumors and controlled seizures will be randomly assigned to stop levetiraceta…

This study tests whether a special nutritional drink taken for 7 days before liver surgery can improve recovery in 100 liver cancer patients. The drink contains ingredients like arginine and omega-3s that may support the immune system. Researchers will measure nutritional status,…

This study is testing whether a newer type of radiation called proton therapy (IMPT) can treat children's brain tumors just as well as standard X-ray therapy (IMRT) but with fewer long-term side effects. About 94 children aged 6 to 16 with low-grade brain tumors will be randomly …

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

This study looks at whether a new type of PET scan (FAPI PET/CT) can find and stage gallbladder and bile duct cancers better than the standard scan. About 60 adults with suspected or confirmed cancer will get both scans to compare accuracy. The goal is to improve detection of can…

This phase II trial tests whether a plant-derived supplement called chlorophyllin can reduce severe mouth sores caused by high-dose radiation given before a stem cell transplant. People aged 12 to 65 with blood cancers who need total body irradiation as part of their transplant p…

This study is testing whether a mobile app called 'Iskhaa' can help brain tumor patients perform their own neurological exams at home. Six hundred participants will use the app to record videos of tasks like speaking and walking, which an AI will analyze. The goal is to see if th…