New trial tests if proton beam therapy spares brain function better than standard X-Rays

NCT ID NCT06831461

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor recurrence, death, or serious side effects like memory decline, hearing loss, or hormone problems. Participants are randomly assigned to one of the two radiation types and followed for at least 5 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Proton beam therapy
What this could lead to
If proton therapy proves better, it could become the new standard for brain tumor radiotherapy, reducing memory loss, hearing loss, and hormone problems while maintaining survival.
What could go wrong
This is a phase 3 trial, but the benefit is not yet proven. Proton therapy is more expensive and less available, and the study may show no meaningful difference in side effects or survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Tata Memorial Centre

    RECRUITING

    Mumbai, India

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