MENINGIOMA

This study is testing a drug called Lutathera in people aged 4 to 39 with certain aggressive brain tumors or meningiomas that have come back or are growing. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dose…

This study tests whether abemaciclib, an FDA-approved cancer drug, can help people with a fast-growing type of brain tumor called grade 3 meningioma. About 72 participants will receive either the drug or a placebo after standard radiation therapy. The goal is to see if the drug c…

This program gives eligible patients with meningioma early access to the investigational drug ITM-11 before it is officially approved. Availability depends on the country, and the treating doctor will decide if the possible benefits outweigh the risks for each patient.

This study tests a new treatment called [212Pb]VMT-α-NET for people with advanced tumors that have a specific marker (SSTR2). The treatment delivers targeted radiation to kill cancer cells while sparing healthy tissue. The study involves up to 300 adults with neuroendocrine tumor…

This study tests the drug cabozantinib in 24 people with meningioma (a type of brain tumor) that has returned or worsened after standard treatments like surgery or radiation. The main goal is to see if the drug can stop the tumor from growing for at least 6 months. Participants m…

This study compares two types of radiation therapy for adults with brain tumors that have a good outlook. Standard X-ray radiation (photon) can cause memory loss, hearing problems, and hormone issues later on. Proton therapy aims to reduce these side effects by delivering less ra…

This study tests several experimental drugs in people with NF2-related schwannomatosis, a genetic condition that causes non-cancerous tumors in the nervous system. About 109 participants will receive one of three drug combinations to see if they can shrink tumors and control the …

This study is for children and teens (ages 3–18) whose solid tumors have come back or not responded to standard treatment. The therapy combines a radioactive drug (Lutathera) that targets specific receptors on tumor cells with a pill (olaparib) that may make the radiation more ef…

This study tests whether a radioactive tracer called [Cu64]DOTATATE can help surgeons find meningioma tumors during surgery using a special probe. About 20 people with suspected or confirmed meningioma who need surgery will take part. The goal is to see if this method is feasible…

This study is testing whether a special type of PET/MRI scan (using a radioactive tracer called 68Ga-DOTATATE) can better detect brain tumors, especially meningiomas, and tell the difference between tumor regrowth and changes from previous treatment. About 200 adults with certain…

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. Th…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and slow wound healing. About 200 adults with certain brain tumors will be randomly assigned to either a standard steroid tape…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce leaks and help patients heal better.

This study looks at whether advanced MRI scans can predict which meningioma patients will experience memory and thinking problems after radiation therapy. Researchers will follow 67 adults with slow-growing brain tumors for two years, comparing MRI images and cognitive test resul…

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults having plann…

This study tests a new MRI technique that measures how stiff a meningioma brain tumor is before surgery. Researchers want to see if this stiffness matches what surgeons find during the operation and the tumor's cell makeup. About 300 patients will take part, and the goal is to he…

This study looks at epigenetic changes in meningioma, a common brain tumor, to find markers that might predict if the tumor will come back. Researchers will analyze tissue and blood samples from 210 patients to develop a personalized risk profile. The goal is to improve follow-up…

This study looks at tiny particles called extracellular vesicles in the blood of people with meningioma (a type of brain tumor) who are receiving radiation therapy. The goal is to find a simple blood test that can help doctors understand the tumor's risk level and track how it re…

This early-stage trial tests a new imaging method that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. The goal is to see if this PET scan can show where immune cells are active without needing a biopsy. About 20 adults with brain tumors schedul…

This early study tests whether a robot can help doctors perform delicate brain blood vessel procedures, such as taking images, blocking blood flow to tumors, or removing clots during a stroke. Ten people already scheduled for these standard treatments may have their procedure don…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…