New hope for rare nerve tumor disorder: Multi-Drug trial launches

NCT ID NCT04374305

Recruiting now Disease control Sponsor: Scott R. Plotkin, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests several experimental drugs in people with NF2-related schwannomatosis, a genetic condition that causes non-cancerous tumors on nerves. The goal is to see if these drugs can shrink tumors and control the disease. About 109 participants will receive one of three drug treatments, and researchers will monitor tumor response and side effects.

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Conditions

The condition(s) this trial relates to.

acoustic neuroma ependymoma meningioma Neurofibromatosis 2 NF2-related schwannomatosis schwannoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPENDYMOMA MENINGIOMA NEUROFIBROMATOSIS TYPE 2 NON-VESTIBULAR SCHWANNOMA VESTIBULAR SCHWANNOMA

Contacts and locations

Locations

Indiana University School of Medicine
NOT_YET_RECRUITING

Indianopolis, Indiana, 46202, United States
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
New York University Langone Medical Center
RECRUITING

New York, New York, 10016, United States
UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States

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