Can laser or ozone therapy better soothe cancer-related mouth pain? a head-to-head comparison
NCT ID NCT07724444
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This study looks back at medical records of adults with head and neck cancer who developed painful mouth sores from radiation or chemotherapy. Researchers will compare how well laser therapy and ozone therapy eased those sores and reduced pain. The goal is to see if one approach offers better relief for this common side effect.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- laser therapy (photobiomodulation) or ozone therapy, delivered as part of routine care
- What this could lead to
- If one therapy proves more effective, it could point toward a better standard of care for managing painful mouth sores during cancer treatment.
- What could go wrong
- This is a small, retrospective study that looks back at past records, so it cannot prove cause and effect. Results may be influenced by differences in how patients were originally treated.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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40 people
The number who actually took part.
- Started
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Sep 2024
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients with histologically confirmed head and neck cancer who developed oral mucositis during radiotherapy, chemotherapy, or concurrent chemoradiotherapy and who previously received either laser therapy or ozone therapy as part of routine clinical care. Participants will be identified retrospectively from existing clinical records. Eligible patients must have documented oral mucositis of World Health Organization grade 1 or higher, a baseline assessment, and at least one post-treatment evaluation. No treatment will be assigned or administered for research purposes.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 years or older. * Histologically confirmed diagnosis of a malignant neoplasm of the head and neck region. * Receipt of radiotherapy, chemotherapy, or concurrent chemoradiotherapy for head and neck cancer. * Clinically documented oral mucositis of World Health Organization grade 1 or higher. * Previous treatment of oral mucositis with either laser therapy or ozone therapy as part of routine clinical care. * Availability of baseline oral mucositis severity assessment and at least one post-treatment assessment. * Availability of sufficient clinical records to determine eligibility and evaluate the study outcomes. Exclusion Criteria: * Active oral infection at the time of oral mucositis assessment, including oral candidiasis or herpes simplex infection. * Use of another specific treatment for oral mucositis within the 2 weeks before initiation of laser therapy or ozone therapy, when documented. * Medical conditions contraindicating laser therapy or ozone therapy, including photosensitivity disorders or severe respiratory disease. * Concurrent participation in another interventional clinical study that could have affected oral mucositis outcomes. * Pregnancy or breastfeeding at the time of treatment, when documented. * Neurological, psychiatric, or cognitive conditions that could have impaired reliable pain assessment or questionnaire completion. * Previous treatment with both laser therapy and ozone therapy during the same episode of oral mucositis. * Incomplete or insufficient clinical records for assessment of the primary outcome.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia
Pavia, Lombardy, 27100, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Systematic oral hygiene intervention for the prevention and control of oral mucositis in children undergoing hematopoietic stem cell transplantation during the perioperative period: a prospective, randomized controlled clinical trial
- Lactobacillus rhamnosus GG alleviates oral mucositis in patients undergoing radiotherapy for malignant head and neck tumors: a randomized controlled trial
- Randomized, Double-Blind, Placebo-Controlled phase II study to evaluate the efficacy of a Copaiba-Based mouthwash combined with Low-Level laser therapy in the prevention of oral mucositis in patients undergoing hematopoietic stem cell transplantation
- A prospective imaging study of target definition and radiation planning workflows on the integrated TrueBeam-HyperSight system for patients receiving radiation therapy
- Impact of aloe vera mouthwash on the prevention and severity of oral mucositis in adults in with hematologic malignancies
- Can a Self-Care program ease Post-Cancer swelling in the head and neck?