Laser light may stop chemo mouth sores in children

NCT ID NCT03983369

Recruiting now Prevention Sponsor: Gustave Roussy, Cancer Campus, Grand Paris Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether low-level laser therapy can prevent severe mouth sores (mucositis) caused by chemotherapy in children and young adults aged 4 to 25. The laser is a painless, non-heating light applied to the mouth before chemotherapy. The trial is double-blind and placebo-controlled, meaning some participants get a sham laser. If successful, it could offer a safe, drug-free way to reduce a common and painful side effect of cancer treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Low-level laser therapy (LLLT) device
What this could lead to: If it works, this could give doctors a simple, non-drug way to prevent painful mouth sores in young cancer patients undergoing chemotherapy.
What could go wrong: This is a Phase 3 trial, but the effect may be modest or no better than placebo. The laser device requires cooperation from children, which may limit its use.

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Conditions

The condition(s) this trial relates to.

stomatitis chemotherapy-induced oral mucositis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUCOSITIS ORAL

Contacts and locations

Locations

CHU de Rennes
RECRUITING

Rennes, 35203, France
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Gustave Roussy
RECRUITING

Villejuif, Val de Marne, 94805, France
Hôpital Robert Debré
RECRUITING

Paris, 75019, France
Institut Curie
RECRUITING

Paris, 75248, France

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