New combo could delay painful mouth sores in cancer radiation

NCT ID NCT06031012

Completed Symptom relief Sponsor: Air Force Military Medical University, China Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal was to see how long it took for grade 2 mouth sores to appear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: glutamine combined with thalidomide
What this could lead to: If it works, this combination could help delay painful mouth sores during radiation, improving quality of life for oral cancer patients.
What could go wrong: This is a completed phase 3 trial with 138 participants, but results are not yet published. Thalidomide has known side effects like drowsiness and nerve damage, and the benefit over glutamine alone may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MUCOSITIS ORAL are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

oral cavity cancer squamous cell carcinoma stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUCOSITIS ORAL

Contacts and locations

Locations

Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University

Xi'an, Shaanxi, 710032, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.