New combo could delay painful mouth sores in cancer radiation
NCT ID NCT06031012
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal was to see how long it took for grade 2 mouth sores to appear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
glutamine combined with thalidomide
What this could lead to
If it works, this combination could help delay painful mouth sores during radiation, improving quality of life for oral cancer patients.
What could go wrong
This is a completed phase 3 trial with 138 participants, but results are not yet published. Thalidomide has known side effects like drowsiness and nerve damage, and the benefit over glutamine alone may be small.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, 710032, China