Glowing cancer cells: a new way to see tumors during surgery?
NCT ID NCT07741643
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether two imaging agents, Panitumumab-IRDye800 and [18F]NOTA-ABY-030, are safe and useful for helping surgeons identify head and neck tumors and cancer-containing lymph nodes during surgery. Adults with head and neck squamous cell carcinoma who are scheduled for tumor removal and neck dissection will receive both agents, and the images will be compared with final pathology results. The goal is to see if this dual-modality approach can improve surgical precision.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two imaging agents: Panitumumab-IRDye800 (Pan800) and [18F]NOTA-ABY-030
- What this could lead to
- If successful, this approach could help surgeons remove more cancer tissue during head and neck surgery, potentially improving outcomes and reducing the need for additional treatments.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the imaging agents may not work as hoped or could cause side effects. The results will need confirmation in larger studies.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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