SQUAMOUS CELL CARCINOMA

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This study tests whether the drug afatinib can shrink tumors in people with advanced squamous cell skin cancer that cannot be treated with surgery or radiation. About 25 adults will receive the drug, and researchers will measure how many respond and how long they live without the…

This study tests whether specially selected immune cells taken from a patient's own lung tumor can be grown in a lab and then given back to shrink advanced non-small cell lung cancer. About 85 adults aged 18–72 with stage IV or unresectable disease and a tumor that can be safely …

This study tests a new drug (HMBD-001) combined with standard treatments (cetuximab, with or without docetaxel) in people with advanced squamous cell cancers that have spread. The goal is to see if the combination is safe and can help control the cancer or slow its growth. About …

This early-phase study tests a new experimental treatment called VET3-TGI, a virus designed to attack cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The mai…

This study tests whether adding two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can improve outcomes for people with newly diagnosed, advanced oral cavity squamous cell carcinoma that has a specific marker (PD-L1 CPS pos…

This study tests which of two chemotherapy combinations works better when given with radiation for advanced head and neck cancer. About 120 people will be randomly assigned to receive either cisplatin or a mix of docetaxel and cetuximab. The researchers will also check if a marke…

This study tests whether using a special dye and camera during throat surgery can help surgeons see and remove poorly blood-supplied tissue, reducing the chance of a painful leak called pharyngocutaneous fistula. About 225 adults with throat cancer who have had prior radiation wi…

This study tests an experimental oral drug called NEO212 in people with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control the disease. About 134 adults will take part across t…

This study tests giving chemotherapy and an immunotherapy drug before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform a less extensive operation, preserving speech, swallowing, and vision. The trial enrolls 75 adults wit…

This study tests whether using special lasers followed by a prescription ointment can effectively treat common skin cancers like basal and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and then apply the ointment at …

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed with surgery. The treatment uses short electric pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to see if …

This study tests a new treatment called T3011, given as a shot directly into tumors, for people with advanced or metastatic solid tumors (like melanoma or lung cancer). It is for adults whose cancer has worsened after standard treatments. The goal is to see if T3011 is safe and c…

This study tests a gene therapy gel applied to skin after removing squamous cell carcinoma (a type of skin cancer) in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare condition causing fragile, blistering skin. The goal is to see if the therapy can lower the …

This study tests a new treatment for advanced squamous cell cancer of the nasal cavity or sinuses. It combines the immunotherapy drug pembrolizumab with chemotherapy (docetaxel and cisplatin/carboplatin) and radiation. The goal is to see if this combination shrinks tumors better …

This study is testing a new platform that uses advanced testing to better understand different types of cancer, including leukemia, myeloma, and solid tumors. The goal is to see if this platform can change the recommended treatment for patients, making it more personalized. About…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether using MRI scans to adjust radiation doses during treatment can reduce damage to nearby healthy organs in people with head and neck cancer. About 35 adults with squamous cell carcinoma will receive standard radiation plus an MRI-guided boost. The goal is t…

This study aims to understand why oral cancer hurts by comparing pain sensitivity between 40 oral cancer patients and 40 healthy volunteers. Researchers will measure how much pressure and tongue stretching causes pain. The goal is to learn more about the role of certain nerve cel…

This study looks at how common anal cancer risk signs are in HIV-negative men who have sex with men (MSM) using PrEP. About 300 participants will answer health questions, provide an anal swab, and undergo a special exam called High-Resolution Anoscopy. The goal is to see how well…

This study looks at whether people with certain cancers prefer getting their immunotherapy (nivolumab or pembrolizumab) as a shot under the skin or as an IV drip. About 880 patients will try both methods and say which they like better. The goal is to understand patient preference…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatments than others, by looking at factors like genetics, lifestyle, and tumor details. The goal is to improve fu…