Vitamin d and light therapy: a new One-Two punch against skin cancer?

NCT ID NCT07241585

Recruiting now Knowledge-focused Sponsor: Case Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking high-dose vitamin D for 6 days before photodynamic therapy (PDT) can improve the immune system's ability to fight nonmelanoma skin cancer. About 54 adults scheduled for Mohs surgery will be randomly assigned to vitamin D or placebo. Researchers will compare immune markers in the tumor tissue to see if the combination triggers a stronger immune response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin D (dietary supplement)
What this could lead to: If successful, this could point toward a way to boost the immune system's attack on skin cancer cells using vitamin D and light therapy.
What could go wrong: This is a very early, small study (54 people) looking at immune markers, not cure rates. It may not lead to any new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

basal cell carcinoma skin carcinoma squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BASAL CELL CARCINOMA NONMELANOMA SKIN CANCER SQUAMOUS CELL CARCINOMA

Contacts and locations

Locations

Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute
RECRUITING

Cleveland, Ohio, 44106, United States

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