BASAL CELL CARCINOMA

This study tests whether combining an immunotherapy drug (cemiplimab), a topical cream (imiquimod), and laser therapy before surgery can cure high-risk basal cell skin cancer. About 18 adults with large or difficult-to-treat tumors will receive the combination or immunotherapy al…

This study tests an experimental mRNA therapy called mRNA-4359, given alone or with standard immunotherapy drugs, in people with advanced solid tumors (like melanoma, lung cancer, or colorectal cancer). The main goals are to find a safe dose and see if the treatment can shrink tu…

This phase 2 trial tests whether the immunotherapy drug nivolumab, alone or combined with relatlimab or ipilimumab, can shrink tumors in people with advanced basal cell carcinoma that cannot be removed by surgery or has spread. About 57 participants will receive one of the drug c…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This phase 2 trial tests whether a combination of two immunotherapy drugs (Opdualag) works better than one drug (nivolumab) alone when given before surgery for high-risk basal cell carcinoma. About 30 people with large or hard-to-treat skin cancers will receive either the combo o…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This study is for people with advanced basal cell skin cancer that has completely disappeared after taking targeted pills (vismodegib or sonidegib). The problem is that the cancer often returns when the pills are stopped. Researchers want to see if giving a short course of radiat…

This pilot study is testing a handheld imaging device called LC-OCT to see if it can clearly show the edges of basal cell skin cancers before Mohs surgery. Researchers will enroll 60 adults who are already scheduled for Mohs surgery. The goal is to find out if the images are good…

This pilot study is testing whether a handheld laser probe, called Raman spectroscopy, can measure the size of skin cancer tumors. Twenty people with basal or squamous cell carcinoma who are already scheduled for brachytherapy will have their tumors scanned with the probe. The go…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests whether an artificial intelligence (AI) model can accurately classify basal cell carcinoma (a common skin cancer) as low-risk or high-risk using dermoscopic images. Researchers will also see if the AI can predict specific subtypes of the cancer. The model's perfo…

This study tests whether taking high-dose vitamin D for 6 days before photodynamic therapy (PDT) can improve the immune system's ability to fight nonmelanoma skin cancer. About 54 adults scheduled for Mohs surgery will be randomly assigned to vitamin D or placebo. Researchers wil…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study aims to develop an artificial intelligence (AI) algorithm that analyzes skin damage (dermatoheliosis) around a melanoma scar to predict whether a patient will respond to anti-PD-1 immunotherapy. Researchers will collect photos and medical data from 700 adults with adva…

This study is testing a new predictive model that analyzes tumor samples to forecast whether a patient with melanoma or other skin cancers will respond to immunotherapy. Researchers will compare the model's predictions with actual patient outcomes over six months. The goal is to …

This study tests whether artificial intelligence (AI) can help surgeons analyze microscope images of skin cancer tissue during surgery. The goal is to give surgeons real-time feedback so they can remove all cancer cells in one go. The trial will enroll 1,000 people with basal cel…