BASAL CELL CARCINOMA

This study tests whether giving immunotherapy drugs (cemiplimab alone or with fianlimab) before surgery can shrink advanced basal cell skin cancers on the head and neck. About 70 adults will receive 2 to 6 infusions before their operation. The goal is to see if the tumors respond…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests whether a combination of two immunotherapy drugs (Opdualag) works better than one drug (nivolumab) alone for people with high-risk basal cell carcinoma that can be surgically removed. About 30 participants will receive treatment before surgery to see if the cance…

This study looks at whether adding radiation therapy after targeted drug treatment (sonic hedgehog inhibitors) can stop advanced basal cell skin cancer from returning. About 82 adults whose cancer fully disappeared on the drugs will either get radiation or not. The goal is to see…

This study tests whether the immune drug nivolumab, alone or combined with relatlimab or ipilimumab, can shrink tumors in people with advanced basal cell carcinoma that cannot be removed by surgery or has spread. About 57 participants will receive treatment to see how well the ca…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether artificial intelligence can help surgeons analyze microscope images during surgery for basal cell carcinoma, the most common skin cancer. The AI would instantly tell the difference between cancer, normal tissue, and inflamed tissue, helping doctors remove…

This study aims to see if a new predictive model can accurately tell which patients with melanoma and other skin cancers will respond to immunotherapy. Researchers will collect tumor tissue, blood, and stool samples from 1,000 participants and compare the model's predictions to a…

This study is testing a new, non-invasive imaging device called LC-OCT to see if it can clearly show the edges of basal cell skin cancers before Mohs surgery. About 60 adults who are already scheduled for Mohs surgery will have their cancer site scanned with this camera. The goal…

This study tests if a handheld laser probe (Raman spectroscopy) can accurately measure how far skin cancer tumors spread. Twenty adults with basal or squamous cell carcinoma will have their tumors scanned with the probe. The goal is to see if this light-based method can help doct…

This study looks at how photodynamic therapy (PDT) affects the immune system around basal cell carcinoma (BCC), a common skin cancer. Researchers want to understand these immune changes to develop better treatments. About 28 adults scheduled for Mohs surgery will have their tumor…