MRNA Vaccine-Like therapy takes on advanced cancers

NCT ID NCT05533697

Recruiting now Disease control Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 20 times

Summary

This study tests an experimental mRNA treatment (mRNA-4359) alone or with standard immunotherapies in people with advanced solid tumors that have not responded to other treatments. The goal is to find the safest dose and see if it can shrink tumors or slow disease progression. About 361 adults will take part across multiple hospitals.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Austin Hospital
RECRUITING

Melbourne, Victoria, 3084, Australia
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, Scotland, G12 0YN, United Kingdom
Carolina BioOncology Institute
COMPLETED

Huntersville, North Carolina, 28078, United States
Churchill Hospital
RECRUITING

Oxford, OX3 7LE, United Kingdom
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
George Washington University
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Guy's and St. Thomas' NHS Foundation Trust
RECRUITING

London, SE1 7EH, United Kingdom
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Imperial College London
RECRUITING

London, W12 0HS, United Kingdom
John Theurer Cancer Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Melanoma Institute Australia
RECRUITING

Wollstonecraft, New South Wales, 2065, Australia
NEXT Oncology Barcelona
RECRUITING

Barcelona, 08023, Spain
NEXT Oncology Madrid
RECRUITING

Madrid, 28223, Spain
NYU Langone Health-Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States
One Clinical Research
RECRUITING

Nedlands, Western Australia, 6009, Australia
Oregon Health Sciences University
RECRUITING

Portland, Oregon, 97239, United States
Orlando Health UF Health Cancer Center
RECRUITING

Orlando, Florida, 32806, United States
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, B15 2GW, United Kingdom
Sara Cannon Research Institute Tennessee
RECRUITING

Nashville, Tennessee, 37203, United States
Southside Cancer Center
RECRUITING

Miranda, New South Wales, 2228, Australia
The Angeles Clinic and Research Institute
RECRUITING

Los Angeles, California, 90025, United States
The University of Chicago Medicine
RECRUITING

Chicago, Illinois, 60637, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States
University College London Hospitals NHS Foundation Trust
RECRUITING

London, NW1 2PG, United Kingdom
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED SOLID TUMORS ADVANCED SOLID TUMORS