New drug combo shows promise against tough skin cancer
NCT ID NCT06624475
First seen Jun 25, 2026 · Last updated Jul 29, 2026 · Updated 3 times
Summary
This phase 2 trial tests whether a combination of two immunotherapy drugs (Opdualag) works better than one drug (nivolumab) alone when given before surgery for high-risk basal cell carcinoma. About 30 people with large or hard-to-treat skin cancers will receive either the combo or single drug. The goal is to see if the tumors shrink or disappear before surgery, which could lead to better outcomes and less disfigurement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab and relatlimab (Opdualag)
- What this could lead to
- If it works, this could offer a more effective pre-surgery treatment for high-risk basal cell carcinoma, potentially reducing tumor size and the need for extensive surgery.
- What could go wrong
- This is a small, early-phase trial with only 30 participants. The combination may not work better than nivolumab alone, and immune-related side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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University of California, Irvine
RECRUITINGIrvine, California, 92868, United States
Contact Email: •••••@•••••
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University of California, San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
Contact Email: •••••@•••••
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94158, United States
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