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Botox before the knife: could a Pre-Surgery injection lead to Better-Looking scars?

NCT ID NCT07720726

Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Aug 27, 2026 · Updated 3 times

Summary

This trial tests whether injecting Botox (abobotulinumtoxin-A) into the forehead muscles just before paramedian forehead flap surgery can improve the cosmetic appearance of the resulting scar. Adults with nasal skin cancer defects needing this reconstruction are randomly assigned to receive either Botox or a saline placebo injection before the procedure. Researchers will then compare scar appearance and patient satisfaction over time using standard scar scales and photographs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an injection of abobotulinumtoxin-A (Dysport, a type of Botox) into the forehead muscles before surgery
What this could lead to
If it works, this could offer a simple way to reduce scarring and improve satisfaction after forehead flap surgery for nasal skin cancer.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. Botox injections carry risks like muscle weakness, headache, or injection site reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults at least 18 years of age with a post-mohs micrographic surgery nasal defect requiring PMFF reconstruction in the operating room or clinic at our institution * No other facial plastic surgery procedure or skin cancer reconstruction performed simultaneously * Lack all the below Exclusion Criteria Exclusion Criteria: * Documented allergy to Abobotulinumtoxin-A * Previous hypersensitivity to Abobotulinumtoxin-A * Hypersensitivity to any botulinum toxin product or excipients * Previous adverse reaction to any botulinum toxin product or excipients * Allergy to cow's milk protein * Infection at proposed injection site * Previous scar or surgery at proposed injection site * Inability to follow-up in clinic * Inability to provide informed consent * Patient currently on aminoglycoside or other agent interfering with neuromuscular transmission * Patient on anticholinergic medication * Pregnancy

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Conditions

The condition(s) this trial relates to.

basal cell carcinoma melanoma squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Basal cell carcinoma Melanoma Skin cancer excision site Squamous cell carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

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