New virus therapy takes on advanced cancers in first human trial

NCT ID NCT05859074

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standard treatments. The main goal is to find the highest safe dose and understand side effects.

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Conditions

The condition(s) this trial relates to.

angiosarcoma basal cell carcinoma cancer cutaneous neuroendocrine carcinoma extramammary Paget disease head and neck squamous cell carcinoma Kaposi's sarcoma melanoma metastatic malignant neoplasm neoplasm Neoplasm Metastasis refractory malignant neoplasm sebaceous adenocarcinoma skin appendage carcinoma skin basal cell carcinoma skin neoplasm skin squamous cell carcinoma squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADNEXAL CARCINOMA ADVANCED CANCER ANGIOSARCOMA BASAL CELL CARCINOMA BCC BCC - BASAL CELL CARCINOMA CUTANEOUS NEOPLASM CUTANEOUS SQUAMOUS CELL CARCINOMA EXTRAMAMMARY PAGET DISEASE HEAD AND NECK SQUAMOUS CELL CARCINOMA HNSCC KAPOSI SARCOMA MELANOMA MERKEL CELL CARCINOMA METASTATIC CANCER REFRACTORY CANCER SCC - SQUAMOUS CELL CARCINOMA SEBACEOUS CARCINOMA SOLID TUMOR

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited protocol activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)
ACTIVE_NOT_RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
ACTIVE_NOT_RECRUITING

Harrison, New York, 10604, United States

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