Case Comprehensive Cancer Center

This study is testing whether giving antibiotics and a special mouthwash before surgery can reduce the amount of bacteria inside oral cancer tumors. Researchers want to see if lowering these bacteria helps the body's immune system fight the cancer better. The trial involves 30 pa…

This study tests whether combining a non-invasive ultrasound treatment called histotripsy with standard chemotherapy works better for people with advanced colorectal cancer that has spread to the liver. About 100 participants will receive both treatments to see if this combinatio…

This study is testing a patient navigation program designed to help people with cancer or suspicious screening results get better access to care and support. It focuses specifically on Black, Hispanic, and residents of high-need areas in Cleveland. The goal is to see if having a …

This study is testing whether a shorter, once-daily radiation schedule works as well as the current standard treatment for breast cancer that returns in the same breast. The goal is to provide a more convenient option that helps participants keep their breast while controlling th…

This study aims to find out if removing lymph nodes during surgery for a rare type of kidney and urinary tract cancer helps prevent the cancer from coming back. Researchers will compare two groups of patients: one that has the standard surgery and another that has the standard su…

This study is exploring whether a specific eating schedule, called intermittent fasting, is safe and helpful for people with ovarian cancer who are receiving chemotherapy before surgery. Researchers want to see if not eating for 16 hours a day on certain days can improve patients…

This study is testing if methimazole, a drug normally used for thyroid conditions, can help control the growth of glioblastoma, an aggressive brain cancer. Researchers believe the drug might work by boosting the body's natural production of a protective compound called hydrogen s…

This study is testing a faster way to plan and deliver a precise type of radiation therapy (SBRT) for people whose cancer has spread to up to five spots in their body. Instead of scheduling a separate planning scan and waiting over a week, doctors will use a recent diagnostic sca…

This study is testing whether adding a personalized exercise program to standard radiation therapy helps men with advanced prostate cancer feel better, function better, and possibly live longer. Researchers will compare quality of life, fatigue, and physical function in 80 men wh…

This study is testing if a new combination of chemotherapy drugs works better than the current standard for advanced bile duct cancer when the first treatment stops working. It combines a pill called trifluridine/tipiracil with an IV drug called oxaliplatin. The goal is to see if…

This study compares two surgical approaches for removing early-stage breast cancer while preserving healthy breast tissue. Researchers are testing whether using a special localization device called Savi Scout® can help surgeons remove less healthy tissue during surgery without le…

This study is testing whether patients need a surgical drain after having part of their pancreas removed. Researchers are comparing the complication rates for patients who receive a standard drain versus those who do not. The goal is to see if avoiding the drain is just as safe a…

This small, early-stage study is testing whether a common vitamin B supplement called nicotinamide riboside (TRU NIAGEN) is safe and tolerable for patients receiving a bone marrow transplant from a donor. The goal is to see if this supplement can help the donor cells settle in an…

This study is testing a new transplant method for adults with high-risk leukemia or myelodysplastic syndromes (MDS) who do not have a perfectly matched donor. It combines cells from a partially matched family donor with cells from umbilical cord blood. The goal is to see if this …

This study is for men newly diagnosed with prostate cancer that has spread to a few other spots in the body. It tests if adding targeted radiation to those specific cancer spots, on top of standard hormone therapy and prostate treatment, helps control the disease better and for l…

This study is testing whether removing only the cancerous part of the bladder, instead of the entire bladder, is a safe and effective treatment for muscle-invasive bladder cancer. About 40 participants will receive standard chemotherapy before and after surgery, followed by the p…

This study is testing a new approach to find cancer early by combining two methods. It will give 1,000 participants a smart scale to track their weight weekly for three years. If someone loses 5% of their weight without trying, they will get a special blood test (GRAIL Galleri) t…

This study is testing whether a simple at-home stool test can reliably detect returning polyps or cancer in people who have already been treated for early-stage colon cancer. Researchers will compare the results of the stool test to the standard follow-up method, a colonoscopy. T…

This study is testing whether artificial intelligence (AI) software can help radiologists spot prostate cancer better on MRI scans. It will enroll 150 men who are scheduled for a prostate biopsy after an MRI. Researchers will compare how well a radiologist, a radiologist using th…

This study is testing a new, simpler way to find Barrett's esophagus, a condition that can lead to a deadly type of esophageal cancer. Researchers want to see if a swallowable balloon device (EsoCheck) and a lab test (EsoGuard) can effectively screen people over 50 who are at ris…

This study is testing a new, faster type of MRI scan to help doctors tell the difference between a brain tumor that has come back and damage caused by previous radiation treatment. Currently, this often requires risky brain surgery to confirm. The research involves 60 people, inc…

This study is testing which methods work best to encourage and help Black or African American men aged 40 and older get screened for prostate cancer. Researchers will compare three different support approaches: providing education, offering navigation help to schedule a test, and…

This study is testing whether using a virtual reality (VR) headset during a single chemotherapy session can help reduce the distress, anxiety, and pain that often come with cancer treatment. 70 adult cancer patients will be randomly assigned to either use VR or choose a standard …

This study is testing whether a 10-day treatment with a device called Scrambler Therapy can reduce pain, numbness, and tingling caused by chemotherapy. About 90 adults with these lasting nerve symptoms will be randomly assigned to receive either the real therapy or a sham (preten…

This study is testing whether starting a special tongue-strengthening exercise program early after surgery can improve speech and swallowing for people with tongue cancer. The program uses a small biofeedback device called a Tongueometer to guide exercises. Researchers want to se…

This study is testing if a special exercise and nutrition program, started during chemotherapy before surgery, can help older adults with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick to the program and if it helps them get stronger, improve thei…

This study is testing whether a smartphone app with an AI chatbot can help improve the well-being of people undergoing cancer treatment. Sixty participants receiving psychotherapy will be randomly assigned to either use the app alongside their usual therapy or receive therapy alo…

This study is testing if an 8-week pulmonary rehabilitation program can help people who have survived advanced non-small cell lung cancer. The program includes exercise training and education, aiming to reduce shortness of breath and fatigue while improving quality of life. Resea…

This study aims to discover new inherited gene changes that might explain why some families develop many different types of cancer. Researchers are enrolling 150 adults, both with and without cancer, from families where at least five relatives have had different cancers. They wil…

This research study aims to understand the biological impact of the 2023 train derailment in East Palestine, Ohio. Researchers will measure DNA damage in residents and see if it relates to how close they lived to the crash site and their reported health symptoms. Participants wil…

This study aims to understand a painful complication called vulvovaginal graft-versus-host disease (GVHD) that can occur after a stem cell transplant. Researchers will observe 40 women to see if the community of bacteria in the vagina changes after the transplant and if those cha…

This study aims to understand how a light-based treatment called photodynamic therapy (PDT) affects the body's immune response to basal cell carcinoma, a common type of skin cancer. Researchers will study 28 participants who are already scheduled for surgery to remove their skin …

This study is testing whether a smartwatch can detect changes in walking stability and daily activities in people being treated for bone cancer. The goal is to see if this data can help doctors monitor treatment response and predict potential complications. Researchers will also …

This study aims to understand if the electrical activity in and around aggressive brain tumors can predict where the cancer will spread next. During standard surgery, researchers will safely record brain signals and take small tissue samples from 10 adult patients. The goal is to…

This study aims to understand how different Mediterranean-style diets affect the body's metabolism in men with early-stage prostate cancer who are on active surveillance. Researchers will provide controlled meals to 30 participants and measure changes in prostate tissue, blood ma…