Case Comprehensive Cancer Center

This study compares two modern treatments for men with low-to-intermediate risk prostate cancer that hasn't spread: a robotic partial prostatectomy (removing part of the prostate through a single port) and high-intensity focused ultrasound (HIFU), which uses sound waves to destro…

This study tests whether using two different stem cell donors together can help people with certain blood cancers (like leukemia and myelodysplastic syndromes) live longer without their cancer coming back. About 36 participants will receive a transplant from a half-matched family…

This study is for people with muscle-invasive bladder cancer that has not spread. It tests whether removing only the part of the bladder with cancer (partial cystectomy) plus nearby lymph nodes, along with standard chemotherapy before and after surgery, works as well as removing …

This study tests if methimazole, a drug used for thyroid conditions, can help people with progressive glioblastoma (a serious brain cancer). Researchers will give different doses to find a safe and effective level. The goal is to see if the drug can slow tumor growth and improve …

This study tests a new combination of two chemotherapy drugs (trifluridine/tipiracil pills plus oxaliplatin by IV) in people with advanced or metastatic biliary tract cancer whose first treatment stopped working or didn't help. The goal is to see if this combo controls the cancer…

This study tests whether a vitamin B3 supplement called nicotinamide riboside (NR) is safe and tolerable for 20 people receiving a bone marrow transplant. The goal is to see if NR can help donor blood stem cells grow faster and reduce recovery time. Participants will take NR pill…

This study tests whether adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver. About 100 adults whose cancer cannot be removed by surgery will receive both treatments. R…

This study tests whether sitagliptin, a diabetes drug, can help the immune system fight glioblastoma, an aggressive brain tumor. About 48 adults with progressive grade 4 glioma will receive sitagliptin before surgery to see if it increases cancer-fighting immune cells in the tumo…

This study tests a new approach for people with brain metastases (cancer that spread to the brain). Doctors give focused radiation (radiosurgery) before surgery to remove the tumor, hoping to prevent it from growing back. The trial involves 36 adults with 1 to 4 brain tumors and …

This study is for people whose breast cancer has returned after previous breast-conserving surgery and whole-breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 session…

This early-stage trial tests whether adding disulfiram (a drug used for alcoholism) and copper to standard chemotherapy is safe for people with sarcomas that returned or didn't respond to treatment. About 24 adults will take part. The main goal is to find the right dose and check…

This study explores whether kidneys containing small, low-risk tumors can be safely used for transplantation after the tumor is removed. It involves 5 donors over age 50 with small kidney tumors who wish to donate, and recipients with kidney failure. The goal is to increase the n…

This study is for men with prostate cancer that has just spread to a few other body parts. It tests whether giving radiation to those spread spots, on top of standard hormone therapy and prostate radiation, helps keep the cancer under control longer. About 200 men will take part,…

This study tests whether giving antibiotics before surgery can lower the amount of bacteria found inside oral cancer tumors. About 30 adults with oral cancer will receive metronidazole and a special mouthwash before their planned surgery. Researchers will compare bacteria levels …

This study looks at whether it is safe to skip placing a drain in the belly after surgery to remove part of the pancreas. About 234 adults having this surgery will be randomly assigned to get a drain or not. The goal is to see if avoiding a drain leads to similar or fewer problem…

This study looks at whether weekly weight tracking combined with a special blood test (GRAIL Galleri) can help find cancer earlier in people who lose weight without trying. About 1,000 adults aged 40 to 80 who have lost at least 5% of their body weight will be followed for up to …

This study tests a new, office-based method to detect Barrett's esophagus—a condition that can lead to esophageal cancer—in people who do not have chronic heartburn. Participants will answer a questionnaire, swallow a capsule balloon test (EsoCheck), and have a lab analysis (EsoG…

This study looks at whether a stool test that checks for certain DNA markers can find polyps or cancer in people who have already had colorectal cancer. About 50 survivors with stage I to III cancer will take the stool test and then have a colonoscopy to see how well the stool te…

This study tests different ways to help Black or African American men aged 40 and older get screened for prostate cancer. Participants will receive either passive navigation, active navigation, or community-based screening to see which method works best. The goal is to increase t…

This study tests whether starting tongue strengthening exercises soon after tongue cancer surgery can improve speech and swallowing. About 40 adults who have part of their tongue removed will use a biofeedback device called the Tongueometer to guide their exercises. The goal is t…

This study looks at whether a program of exercise and nutrition during chemotherapy can help elderly patients (65+) with ovarian or pancreatic cancer get stronger before surgery. About 22 participants will follow the program to see if they can stick with it. The goal is to improv…

This study looks at whether an 8-week pulmonary rehabilitation program can help people with advanced non-small cell lung cancer who have trouble breathing and feel tired. Half of the 85 participants will do the rehab program, while the other half will get their usual care. Resear…

This study tests a quicker way to plan stereotactic body radiation therapy (SBRT) for people whose cancer has spread to up to five spots (oligometastatic disease). Normally, planning SBRT takes a week or more because it requires a separate CT scan. Here, doctors will use the pati…

This study looks at whether timed fasting (not eating for 16 hours a day, 5 days a week) is safe and doable for women getting chemotherapy before ovarian cancer surgery. Researchers want to see if it can improve quality of life and reduce side effects compared to a standard diet.…

This study tests whether an artificial intelligence (AI) app can improve quality of life and reduce anxiety or depression in people with cancer who are already receiving psychotherapy. About 60 participants will be randomly assigned to either get the app plus usual therapy or jus…

This study tests whether Scrambler Therapy, a device that sends mild electrical signals to the skin, can reduce pain, numbness, and tingling caused by chemotherapy. About 90 adults with persistent nerve pain after chemo will receive either real or sham treatment for 10 sessions. …

This study looks at whether giving spine radiation in one session or two sessions is better at preventing spine fractures. People with cancer that has spread to the spine will receive focused radiation to relieve pain and symptoms. The main goal is to see which approach lowers th…

This study creates a registry of patients who receive proton beam therapy at University Hospitals. Researchers will follow participants over time to evaluate treatment outcomes. Anyone treated with proton therapy at the center who can give consent can join.

This study looks at how different Mediterranean-style diets affect the body's metabolism in men with early-stage prostate cancer who are not yet receiving treatment. Researchers will provide special meals to 30 men and measure changes in their prostate tissue and blood. The goal …

This study looks at whether artificial intelligence (AI) can help doctors find prostate cancer on MRI scans. About 150 men aged 55 to 80 who are scheduled for a prostate biopsy will take part. Researchers will compare how well radiologists detect cancer with and without AI assist…

This study looks at whether removing lymph nodes during surgery for a rare kidney cancer (upper tract urothelial carcinoma) helps prevent the cancer from coming back. About 94 adults will be randomly assigned to have standard surgery alone or with lymph node removal. The main goa…

This study tests whether a smartwatch can track changes in walking and daily activities in 60 people with bone cancer (osteosarcoma or metastatic bone disease) in the legs or pelvis. Participants wear the watch at least 12 hours a day and complete weekly questionnaires for 12 wee…

This study looks at how the collection of bacteria, fungi, and viruses in the vagina changes in women who receive a stem cell transplant. Researchers want to learn why some women develop a painful condition called vulvovaginal graft-versus-host disease (GVHD). About 40 women will…

This study looks at whether a special MRI scan taken before robotic surgery for HPV-positive tonsil cancer can predict if the cancer will be completely removed. About 30 adults will get an MRI, and doctors will compare the scan results to the actual surgical outcomes. The goal is…

This study tests a program that helps minority cancer patients learn about clinical trials and make informed decisions. About 240 adults with cancer who are not white or are Hispanic will take part. The program combines education and a patient navigator to improve knowledge and a…

This study aims to discover new gene changes that may increase cancer risk by analyzing DNA from families where several members have had different types of cancer. Adults with or without cancer who have a strong family history of cancer can join. Researchers will collect blood sa…

This study looks at whether a probiotic supplement called BIOHM can change the bacteria and fungi living in breast tumors and the gut of people with breast cancer. Researchers want to understand how these tiny organisms might affect cancer development. About 100 participants with…

This study looks at two methods for removing breast cancer in women with early-stage breast cancer. One method removes extra tissue around the tumor routinely, while the other uses a special marker called Savi Scout to remove only the needed tissue. The goal is to see if the targ…

This study looks at how photodynamic therapy (PDT) affects the immune system around basal cell carcinoma (BCC), a common skin cancer. Researchers want to understand these immune changes to develop better treatments. About 28 adults scheduled for Mohs surgery will have their tumor…

This study tests a new way to help people with cancer, especially those from African American, Hispanic, or underserved areas. The program provides extra support and resources to reduce distress and improve quality of life. About 375 adults with suspicious cancer findings or a ca…

This early-phase study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small tissue samples from areas with unusual activity and track tumor progression on follow-up MRI scans. The goal is to…

This study looks at whether chemicals from the 2023 train derailment in East Palestine, Ohio, caused DNA damage in local residents. Researchers will collect blood, spit, hair, and nail samples from 500 volunteers and compare DNA changes with how close they lived to the derailment…

This study tests a faster, more detailed MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can tell the difference between a brain tumor coming back and radiation-induced brain damage. About 60 adults who have had brain radiation, have new or untreated bra…