Old alcoholism drug repurposed to fight tough sarcomas
NCT ID NCT05210374
First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 3 times
Summary
This early-stage trial is testing whether adding disulfiram (a drug used for alcohol dependence) and copper gluconate to a standard chemotherapy (Doxil) is safe for people with sarcomas that have returned or not responded to prior treatments. About 24 participants will take these drugs by mouth and by IV over several cycles. The main goal is to find the safest dose and check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- disulfiram, copper gluconate, and liposomal doxorubicin (Doxil)
- What this could lead to
- If it works, this could point toward a new treatment option for sarcomas that have stopped responding to standard therapy.
- What could go wrong
- This is a very early phase 1 trial with only 24 participants, focused on safety and dosing. It is too soon to know if the combination will be effective, and there may be significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cleveland Clinic, Case Comprehensive Cancer Center
RECRUITINGCleveland, Ohio, 44122, United States