Case Comprehensive Cancer Center

This study tests an experimental drug called elranatamab in people newly diagnosed with light chain (AL) amyloidosis who have not yet had treatment. The drug works by helping the body's immune cells find and destroy the abnormal plasma cells that cause the disease. Researchers wa…

This study tests whether adding a lymphatic bypass (LVB) during standard lymph node removal can prevent lymphedema—a painful arm swelling that affects up to 40% of breast cancer survivors. About 400 patients with node-positive breast cancer will be randomly assigned to receive ei…

This study tests whether replacing the intestines or multiple abdominal organs can help people with a rare cancer called pseudomyxoma peritonei (PMP) that cannot be removed by standard surgery. About 20 participants will receive a transplant and be followed for 12 months to see i…

This study tests whether freezing esophageal cancer tumors with liquid nitrogen before chemotherapy improves treatment. About 40 adults with advanced esophageal cancer will be randomly assigned to receive either cryotherapy plus chemo or chemo alone. The goal is to see if the fre…

This study is for people whose cancer has spread to the brain. It compares two types of whole brain radiation: one that avoids the memory center (hippocampus) and one that avoids several brain areas linked to thinking. The goal is to see which method better protects memory and th…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have finished treatment for breast, prostate, or colorectal cancer. About 76 participants with mild to moderate depression will listen to short audio exercises each day for s…

This study tests whether freeze-dried miracle fruit (MiraBurst) can improve taste changes caused by cancer treatment in adults with solid tumors. Participants take one mini-square up to four times daily before meals for 90 days. The goal is to ease a common side effect that can m…

This study tests whether a simple bowel irrigation technique can help people who have bowel control problems after rectal cancer surgery. About 60 adults who recently had surgery and a temporary colostomy will try the irrigation method or standard care. The goal is to see if it i…

This study tests a quicker way to deliver radiation therapy to ease severe belly pain caused by pancreatic cancer. Normally, planning this treatment takes a week or more because a separate CT scan is needed. Here, doctors will use the patient's existing diagnostic CT scan to plan…

This study looks at whether wearable sensors (like smartwatches) and electronic surveys are practical and acceptable for people taking part in early-phase cancer clinical trials. About 30 participants will wear a smartwatch and answer questions through a phone app for 4 weeks. Th…

This study surveys 240 breast cancer patients (stages I–III) who have had chemotherapy or hormone therapy. Researchers want to learn which herbs and supplements people use, how ethnicity affects those choices, and whether these products interact with standard treatments. Particip…

This study looks at whether taking vitamin D before a light-based treatment (photodynamic therapy, or PDT) can help the immune system fight nonmelanoma skin cancer. About 54 adults scheduled for skin cancer surgery will take either vitamin D or a placebo for 6 days, then receive …

This study looks at whether people who have survived cancer have higher levels of certain proteins (Fatty Acid Binding Proteins) and aging markers in their blood compared to people who never had cancer. Researchers think these higher levels might come from the cancer or its treat…