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Could Once-Daily radiation replace Twice-Daily for breast cancer recurrence?

NCT ID NCT06129747

Recruiting now Disease control Sponsor: Case Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study is for women whose breast cancer has come back after initial breast-conserving surgery and whole breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 sessions works just as well. Researchers will track side effects and whether the cancer returns in the breast.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiation therapy
What this could lead to
If successful, this could offer a shorter, more convenient radiation schedule for women whose breast cancer has returned after initial treatment.
What could go wrong
This is a small Phase 2 study with only 55 participants, so results may not apply to everyone. The once-daily schedule might be less effective or cause different side effects than the standard approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ invasive ductal breast carcinoma invasive tubular breast carcinoma medullary thyroid gland carcinoma mucinous adenocarcinoma neoplasm papillary carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER TUMOR, BREAST

Contacts and locations

Locations

  • Cleveland Clinic Taussig Cancer Center, Case Comprehensive Cancer Center

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Email: •••••@•••••

  • University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center

    RECRUITING

    Cleveland, Ohio, 44106-5065, United States

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