New Pill-and-IV combo takes on bile duct cancer in small trial
NCT ID NCT07146646
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing a combination of two chemotherapy drugs—trifluridine/tipiracil (pills) and oxaliplatin (IV)—in people with advanced or metastatic biliary tract cancer whose first treatment stopped working. The goal is to see if this combo can control the cancer better than the standard second-line therapy. About 27 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trifluridine/tipiracil (pills) plus oxaliplatin (IV)
- What this could lead to
- If this works, it could offer a new second-line treatment option for people with advanced biliary tract cancer, helping to control the disease longer.
- What could go wrong
- This is a small, early-phase trial with only 27 participants. The combination may not work better than existing treatments, and side effects could be significant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic Taussig Cancer Center, Case Comprehensive Cancer Center
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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