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Can a simple score spot hidden gallbladder cancer?

NCT ID NCT06531408

Diagnosis Sponsor: University Hospital Plymouth NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are studying whether they can predict which patients having routine gallbladder removal for gallstones or related problems might have unsuspected gallbladder cancer. They plan to collect data from up to 30,000 adults and use risk factors to build a scoring system. The goal is to see if the score can identify high-risk gallbladders that need lab testing, while possibly skipping testing for low-risk ones.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the scoring system works, surgeons could flag high-risk gallbladders for lab testing and spare low-risk patients unnecessary analysis.
What could go wrong
The study is observational and relies on data collection across many hospitals, so the score may not predict cancer accurately enough to change practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients undergoing cholecystectomy for benign gallbladder diseases (most often gallstone disease), who do not have a risk of gallbladder cancer which is significantly higher than the typical patient.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: All adult patients (\>=18 years of age) undergoing cholecystectomy (including subtotal and remnant cholecystectomy) for benign indications: * Symptomatic Gallstone Disease (includes Gallstone Pancreatitis) * Biliary Dyskinesia Exclusion Criteria: Participants may not enter the study if ANY of the following apply: * Imaging suspicious for/confirming type III/IV Mirizzi syndrome. * History of gallbladder or biliary tree malignancies * Any pre-operative clinical suspicion of Gallbladder or biliary tree malignancy, (even if subsequently dismissed or disproven) * Presence of Gallbladder polyps ≥5mm * Biliary tree abnormalities, including Primary Sclerosing Cholangitis and Choledochal Cysts * Patients undergoing cholecystectomy as a part of, or incidental to, another procedure.

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Conditions

The condition(s) this trial relates to.

gallbladder cancer gallbladder neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gallbladder cancer

Contacts and locations

Locations

  • University Hospitals Plymouth NHS Trust

    Plymouth, Devon, PL6 8DH, United Kingdom

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