Scientists hunt for new cancer genes in families with unusual cancer patterns
NCT ID NCT04860453
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study is collecting DNA and medical history from 150 people in families where multiple members have had different types of cancer. Researchers will analyze the participants' exomes (the protein-coding parts of their DNA) to find new gene mutations that might explain why these families have so many cancers. The goal is to discover inherited genetic changes that current tests might miss, which could improve genetic counseling and screening for at-risk families.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could identify new inherited gene mutations that increase cancer risk, potentially leading to better genetic testing and screening for families.
- What could go wrong
- This is an observational study, not a treatment trial. It may not find new mutations, and any discoveries would need years of further research before they help patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
RECRUITINGCleveland, Ohio, 44106, United States
Contact Email: •••••@•••••
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