Blood test may let some throat cancer patients skip radiation after surgery
NCT ID NCT07513389
First seen Apr 11, 2026 · Last updated Jun 23, 2026 · Updated 13 times
Summary
This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, many would also get radiation afterward to lower the risk of cancer coming back. But radiation has side effects. This trial tests whether patients with a negative blood test two weeks after surgery can safely skip radiation and instead be monitored with regular blood tests and checkups. If the blood test shows cancer returning, they can get treatment then. The goal is to see if this approach keeps cancer under control while avoiding unnecessary radiation.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
active surveillance with ctHPVDNA blood test (NavDx)
What this could lead to
If successful, this could allow many throat cancer patients to avoid the side effects of radiation after surgery, relying on a simple blood test to catch any return of cancer early.
What could go wrong
This is a small, early-phase trial with only 36 participants, so results may not apply to everyone. There is a risk that skipping radiation could allow cancer to return before the blood test detects it.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.